Panagis Filippakopoulos

Overview

Best Publications

• Selective inhibition of BET bromodomains.

  Panagis Filippakopoulos;Jun Qi;Sarah Picaud;Yao Shen

  4671
  Citations

• Histone recognition and large-scale structural analysis of the human bromodomain family.

  Panagis Filippakopoulos;Sarah Picaud;Maria Mangos;Tracy Keates

  1685
  Citations

• Targeting bromodomains: epigenetic readers of lysine acetylation

  Panagis Filippakopoulos;Stefan Knapp

  1278
  Citations

• Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

  Alastair J. Barr;Emilie Ugochukwu;Wen Hwa Lee;Oliver N.F. King

  555
  Citations

• Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

  Takao Fujisawa;Panagis Filippakopoulos;Panagis Filippakopoulos

  535
  Citations

• Bromodomains as therapeutic targets.

  Susanne Muller;Panagis Filippakopoulos;Stefan Knapp

  533
  Citations

• RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.

  Sarah Picaud;Christopher Wells;Ildiko Felletar;Deborah Brotherton

  500
  Citations

• Small-molecule inhibition of BRDT for male contraception

  Martin M. Matzuk;Michael R. McKeown;Panagis Filippakopoulos;Qinglei Li

  491
  Citations

• The bromodomain interaction module.

  Panagis Filippakopoulos;Stefan Knapp;Stefan Knapp

  431
  Citations

• Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

  Pietro Ciceri;Susanne Müller;Alison O'Mahony;Oleg Fedorov

  382
  Citations

• Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

  Duncan A Hay;Oleg Fedorov;Sarah Martin;Dean C Singleton

  331
  Citations

• PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains

  Sarah Picaud;David Da Costa;Angeliki Thanasopoulou;Panagis Filippakopoulos

  293
  Citations

• Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

  Nicholas Kwiatkowski;Nannette Jelluma;Panagis Filippakopoulos;Meera Soundararajan

  270
  Citations

• Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

  Li Feng;Yann Geisselbrecht;Sebastian Blanck;Alexander Wilbuer

  257
  Citations

• 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.

  David S. Hewings;Minghua Wang;Martin Philpott;Oleg Fedorov

  255
  Citations

• Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

  Sarah Picaud;Sarah Picaud;Oleg Fedorov;Oleg Fedorov;Angeliki Thanasopoulou;Katharina Leonards

  247
  Citations

• Identification of a Chemical Probe for Bromo and Extra C‑Terminal Bromodomain Inhibition through Optimization of a Fragment- Derived Hit

  Paul V. Fish;Panagis Filippakopoulos;Gerwyn Bish;Paul E. Brennan

  234
  Citations

• Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation

  Panagis Filippakopoulos;Michael Kofler;Oliver Hantschel;Gerald D. Gish

  234
  Citations

• Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.

  Tania Tahtouh;Jonathan M. Elkins;Panagis Filippakopoulos;Meera Soundararajan

  233
  Citations

• Abstract 5387: Dual kinase/bromodomain inhibitors for rationally designed polypharmacology

  Elizabeth R. Quinn;Pietro Ciceri;Susanne Müller-Knapp;Alison O'Mahony

  0
  Citations