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Biology and Biochemistry

D-Index
88
Citations
22883
World Ranking
2751
National Ranking
1421

Research.com Recognitions

  • 1983 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

William Dowhan is affiliated with The University of Texas Health Science Center at Houston in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a specific focus on Molecular Biology, Genetics, Plant Science, Biochemistry, and Endocrine and Autonomic Systems as subfields.

The scientist's work explores several main topics, including:

  • Lipid Membrane Structure and Behavior
  • Protein Structure and Dynamics
  • Bacterial Genetics and Biotechnology
  • Mitochondrial Function and Pathology
  • RNA and protein synthesis mechanisms
  • ATP Synthase and ATPases Research
  • Bioactive Compounds in Plants

Recent publications by William Dowhan cover various aspects of membrane biochemistry and bacterial genetics. These include:

  • Phospholipid distribution in the cytoplasmic membrane of Gram-negative bacteria is highly asymmetric, dynamic, and cell shape-dependent (2020, Science Advances)
  • Cardiolipin is required in vivo for the stability of bacterial translocon and optimal membrane protein translocation and insertion (2020, Scientific Reports)
  • Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex (2023, Nature Communications)
  • Cardiolipin Synthesis in Skeletal Muscle Is Rhythmic and Modifiable by Age and Diet (2020, Oxidative Medicine and Cellular Longevity)
  • Eugene P. Kennedy's Legacy: Defining Bacterial Phospholipid Pathways and Function (2021, Frontiers in Molecular Biosciences)

William Dowhan frequently collaborates with several researchers, particularly:

  • Mikhail Bogdanov
  • Eugenia Mileykovskaya
  • Sergey Ryabichko
  • Ramziya Kiyamova
  • Heidi Vitrac

Publication venues where this scientist has contributed multiple articles include:

  • Science Advances
  • Scientific Reports
  • Nature Communications
  • Biochemistry (Moscow)
  • Oxidative Medicine and Cellular Longevity

In 1983, William Dowhan was recognized as a Fellow of the John Simon Guggenheim Memorial Foundation.

Best Publications

  • MOLECULAR BASIS FOR MEMBRANE PHOSPHOLIPID DIVERSITY: Why Are There So Many Lipids?

    William Dowhan

  • Gluing the respiratory chain together. Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane.

    Mei Zhang;Eugenia Mileykovskaya;William Dowhan

  • The ATPase activity of secA is regulated by acidic phospholipids, secY, and the leader and mature domains of precursor proteins

    Roland Lill;William Dowhan;William Wickner

  • An essential role for a phospholipid transfer protein in yeast Golgi function.

    Vytas A. Bankaitis;Jacqueline R. Aitken;Ann E. Cleves;William Dowhan

  • Visualization of phospholipid domains in Escherichia coli by using the cardiolipin-specific fluorescent dye 10-N-nonyl acridine orange.

    Eugenia Mileykovskaya;William Dowhan

  • Cardiolipin membrane domains in prokaryotes and eukaryotes.

    Eugenia Mileykovskaya;William Dowhan

  • Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein.

    Ann E. Cleves;Todd P. McGee;Eric A. Whitters;Kathleen M. Champlon

  • Biosynthesis and function of phospholipids in Escherichia coli.

    Christian R H Raetz;William Dowhan

  • Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis.

    Darin B. Ostrander;Darin B. Ostrander;Genevieve C. Sparagna;Genevieve C. Sparagna;Andrew A. Amoscato;Jeanie B. McMillin;Jeanie B. McMillin

  • Cardiolipin is essential for organization of complexes III and IV into a supercomplex in intact yeast mitochondria

    Mei Zhang;Eugenia Mileykovskaya;William Dowhan

  • Cardiolipin and apoptosis.

    Jeanie B McMillin;William Dowhan

  • Phosphatidylglycerol is involved in protein translocation across Escherichia coli inner membranes.

    T de Vrije;R L de Swart;W Dowhan;J Tommassen

  • Functional roles of lipids in membranes

    William Dowhan;Mikhail V Bogdanov;Eugenia Mileykovskaya

  • Sequence and inactivation of the pss gene of Escherichia coli. Phosphatidylethanolamine may not be essential for cell viability.

    Anne DeChavigny;Philip N. Heacock;William Dowhan

  • Lipid-Dependent Membrane Protein Topogenesis

    William Dowhan;Mikhail V Bogdanov

  • A polytopic membrane protein displays a reversible topology dependent on membrane lipid composition.

    Mikhail V Bogdanov;Phillip N. Heacock;William Dowhan

  • Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes.

    Eugenia Mileykovskaya;William Dowhan

  • Lipid-assisted protein folding.

    Mikhail V Bogdanov;William Dowhan

  • The PEL1 Gene (Renamed PGS1) Encodes the Phosphatidylglycero-phosphate Synthase ofSaccharomyces cerevisiae

    Shao Chun Chang;Philip N. Heacock;Constance J. Clancey;William Dowhan

  • A PHOSPHOLIPID ACTS AS A CHAPERONE IN ASSEMBLY OF A MEMBRANE TRANSPORT PROTEIN

    Mikhail Bogdanov;Jianzhong Sun;H. Ronald Kaback;William Dowhan

Frequent Co-Authors

Yang Xia
Yang Xia The University of Texas Health Science Center at Houston
Rodney E. Kellems
Rodney E. Kellems The University of Texas Health Science Center at Houston
Ziqiang Guan
Ziqiang Guan Duke University
William Margolin
William Margolin The University of Texas Health Science Center at Houston
Haifa Shen
Haifa Shen Houston Methodist
Arnold S. Bayer
Arnold S. Bayer University of California, Los Angeles
Travis Nemkov
Travis Nemkov University of Colorado Denver
Angelo D'Alessandro
Angelo D'Alessandro University of Colorado Denver
Cesar A. Arias
Cesar A. Arias The University of Texas Health Science Center at Houston
Jianping Jin
Jianping Jin Zhejiang University

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