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Biology and Biochemistry

D-Index
74
Citations
14583
World Ranking
5758
National Ranking
2723

Overview

Rodney E. Kellems is affiliated with The University of Texas Health Science Center at Houston in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to physiology, molecular biology, pediatrics, perinatology, child health, obstetrics and gynecology, as well as pulmonary and respiratory medicine.

The main topics addressed in their work include:

  • Erythrocyte Function and Pathophysiology
  • Sphingolipid Metabolism and Signaling
  • Pregnancy and Preeclampsia Studies
  • Pancreatic Function and Diabetes
  • Epigenetics and DNA Methylation
  • Neonatal Health and Biochemistry
  • Blood Properties and Coagulation

Recent papers authored by Rodney E. Kellems reflect a focus on erythrocyte biology, metabolic regulation, and disease mechanisms. They include:

  • "Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies" (2020), published in Circulation Research
  • "Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis" (2022), published in Cell Metabolism
  • "Reciprocal upregulation of hypoxia-inducible factor-1α and persistently enhanced placental adenosine signaling contribute to the pathogenesis of preeclampsia" (2020), published in The FASEB Journal
  • "Tissue transglutaminase: a multifunctional and multisite regulator in health and disease" (2023), published in Physiological Reviews
  • "Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming" (2021), published in PLoS Biology

Their frequent co-authors include:

  • Yang Xia (17 co-publications)
  • Angelo D'Alessandro (11 co-publications)
  • Chang-Han Chen (9 co-publications)
  • Benjamin C. Brown (9 co-publications)
  • Weiru Zhang (7 co-publications)

Kellems has published extensively in venues such as Blood, The FASEB Journal, Journal of the American Society of Nephrology, Advanced Science, and Cell Metabolism. The highest volume of publications are within Blood, followed by The FASEB Journal.

Best Publications

  • Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

    F W Alt;R E Kellems;J R Bertino;R T Schimke

  • Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice

    Cissy C Zhou;Yujin Zhang;Roxanna A Irani;Hong Zhang

  • Cytoplasmic type 80S ribosomes associated with yeast mitochondria. IV. Attachment of ribosomes to the outer membrane of isolated mitochondria.

    R E Kellems;V F Allison;R A Butow

  • Metabolic Consequences of Adenosine Deaminase Deficiency in Mice Are Associated with Defects in Alveogenesis, Pulmonary Inflammation, and Airway Obstruction

    Michael R. Blackburn;Jonathan B. Volmer;Janci L. Thrasher;Hongyan Zhong

  • Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.

    F W Alt;R E Kellems;R T Schimke

  • Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cells.

    Yang Xia;Hong Wen;Sol Bobst;Mary Clare Day

  • Interleukin-6 Underlies Angiotensin II-induced Hypertension and Chronic Renal Damage

    Weiru Zhang;Wei Wang;Hong Yu;Yujin Zhang

  • Detrimental effects of adenosine signaling in sickle cell disease

    Yujin Zhang;Yingbo Dai;Yingbo Dai;Jiaming Wen;Jiaming Wen;Weiru Zhang;Weiru Zhang

  • Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: Correlation with disease severity

    Athar H. Siddiqui;Roxanna A. Irani;Sean C. Blackwell;Susan M. Ramin

  • Adenosine Deaminase-deficient Mice Generated Using a Two-stage Genetic Engineering Strategy Exhibit a Combined Immunodeficiency

    Michael R. Blackburn;Surjit K. Datta;Rodney E. Kellems

  • Angiotensin II Induces Soluble fms-Like Tyrosine Kinase-1 Release via Calcineurin Signaling Pathway in Pregnancy

    Cissy Chenyi Zhou;Shakil Ahmad;TieJuan Mi;Lingwei Xia

  • Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation.

    Michael R Blackburn;Rodney E Kellems

  • Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia

    Kaiqi Sun;Yujin Zhang;Angelo D’Alessandro;Travis Nemkov

  • Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice.

    Maki Wakamiya;Michael R. Blackburn;Roland Jurecic;Mark J. McArthur

  • Angiotensin Receptor Agonistic Autoantibodies and Hypertension Preeclampsia and Beyond

    Yang Xia;Rodney E. Kellems

  • Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling

    Cissy Chenyi Zhou;Shakil Ahmad;Tiejuan Mi;Shahrzad Abbasi

  • Deduced amino acid sequence of Escherichia coli adenosine deaminase reveals evolutionarily conserved amino acid residues: implications for catalytic function

    Chang Zy;Nygaard P;Chinault Ac;Kellems Re

  • Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability.

    Julio C. Morales;Zhenfang Xia;Tao Lu;Melissa B. Aldrich

  • Antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization through angiotensin receptor activation

    Theingi M. Thway;Sergiy G. Shlykov;Mary Clare Day;Barbara M. Sanborn

  • Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

    Tiejuan Mi;Shahrzad Abbasi;Hong Zhang;Karen Uray

Frequent Co-Authors

Yang Xia
Yang Xia The University of Texas Health Science Center at Houston
Michael R. Blackburn
Michael R. Blackburn The University of Texas Health Science Center at Houston
Holger K. Eltzschig
Holger K. Eltzschig The University of Texas Health Science Center at Houston
Angelo D'Alessandro
Angelo D'Alessandro University of Colorado Denver
Robert T. Schimke
Robert T. Schimke Stanford University
Travis Nemkov
Travis Nemkov University of Colorado Denver
Jianping Jin
Jianping Jin Zhejiang University
Kirk C. Hansen
Kirk C. Hansen University of Colorado Anschutz Medical Campus
William Dowhan
William Dowhan The University of Texas Health Science Center at Houston
Baha M. Sibai
Baha M. Sibai The University of Texas Health Science Center at Houston

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