World's Best Scientists 2026 revealed!
Michael S. Hershfield

Michael S. Hershfield

D-Index & Metrics

Biology and Biochemistry

D-Index
84
Citations
19463
World Ranking
3396
National Ranking
1707

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Michael S. Hershfield is affiliated with Duke University in the United States. Their research spans multiple intersecting fields in biomedical sciences with a strong emphasis on immunology, genetics, and molecular biology.

The researcher's main fields of study include Biochemistry, Genetics and Molecular Biology; Medicine; and Immunology and Microbiology. Within these disciplines, key subfields involve Immunology, Genetics, Physiology, Epidemiology, and Molecular Biology.

Major topics covered in their work encompass Immunodeficiency and Autoimmune Disorders, Adenosine and Purinergic Signaling, Cytomegalovirus and herpesvirus research, Virus-based gene therapy research, Biochemical and Molecular Research, Blood disorders and treatments, and CAR-T cell therapy research.

Frequent coauthors collaborating with Michael S. Hershfield include Teresa K. Tarrant, Donald B. Kohn, Theodore B. Moore, Rebecca H. Buckley, and Fabio Candotti.

Their publications are regularly found in these scientific venues: Journal of Clinical Immunology, Frontiers in Immunology, Journal of Allergy and Clinical Immunology, Clinical Immunology, and Blood.

Recent papers showcase a focus on gene therapy and immunodeficiency disorders, highlighting contributions such as:

  • "Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency" (2021), published in New England Journal of Medicine
  • "Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience From India" (2020), published in Arthritis & Rheumatology
  • "Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients" (2021), published in Journal of Clinical Immunology
  • "Evaluation and Management of Deficiency of Adenosine Deaminase 2" (2023), published in JAMA Network Open
  • "Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart" (2022), published in Advanced Science

Michael S. Hershfield has been recognized as a Member of the Association of American Physicians.

Best Publications

  • Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

    Qing Zhou;Dan Yang;Amanda K Ombrello;Andrey V Zavialov

  • Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase.

    M S Hershfield;M S Hershfield;M S Hershfield;R H Buckley;R H Buckley;R H Buckley;M L Greenberg;M L Greenberg;M L Greenberg;A L Melton;A L Melton;A L Melton

  • Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase.

    Nancy J Ganson;Susan J Kelly;Edna Scarlett;John S Sundy

  • T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates

    Kohn Db;Hershfield Ms;Carbonaro D;Shigeoka A

  • Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine arabinoside. A basis for direct toxic effects of analogs of adenosine.

    M.S. Hershfield

  • Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation.

    Anna E. Denoble;Kim M. Huffman;Thomas V. Stabler;Susan J. Kelly

  • Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer.

    Nancy J. Ganson;Thomas J. Povsic;Bruce A. Sullenger;John H. Alexander

  • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript

    C. G. Begley;P. D. Aplan;M. P. Davey;K. Nakahara

  • Clinical Pharmacogenetics Implementation Consortium Guidelines for Human Leukocyte Antigen-B Genotype and Allopurinol Dosing

    M S Hershfield;J T Callaghan;J T Callaghan;W Tassaneeyakul;T Mushiroda

  • Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase.

    Yael Levy;Michael S. Hershfield;Cristina Fernandez-Mejia;Stephen H. Polmar

  • Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.

    Lawrence R. Finger;Jacob Kagan;George Christopher;Joanne Kurtzberg

  • Gene therapy for adenosine deaminase–deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans

    Fabio Candotti;Kit L. Shaw;Linda Muul;Denise Carbonaro

  • Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation.

    R H Buckley;S E Schiff;H A Sampson;R I Schiff

  • Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout

    John S. Sundy;Nancy J. Ganson;Susan J. Kelly;Edna L. Scarlett

  • Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

    Michael S Hershfield;Nancy J Ganson;Susan J Kelly;Edna L Scarlett

  • How I treat ADA deficiency

    H. Bobby Gaspar;Alessandro Aiuti;Fulvio Porta;Fabio Candotti

  • In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.

    M S Hershfield;N M Kredich;D R Ownby;H Ownby

  • S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity

    Michael S. Hershfield;Nicholas M. Krodich

  • Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin

    Michael S. Hershfield;Joanne Kurtzberg;Elizabeth Harden;Joseph O. Moore

  • CD7+, CD4-, CD8- acute leukemia: a syndrome of malignant pluripotent lymphohematopoietic cells

    Joanne Kurtzberg;Thomas A. Waldmann;Thomas A. Waldmann;Michael P. Davey;Michael P. Davey;Sandra H. Bigner;Sandra H. Bigner

Frequent Co-Authors

Fabio Candotti
Fabio Candotti National Institutes of Health
Joanne Kurtzberg
Joanne Kurtzberg Duke University
Donald B. Kohn
Donald B. Kohn University of California, Los Angeles
Rebecca H. Buckley
Rebecca H. Buckley Duke University
Ivona Aksentijevich
Ivona Aksentijevich National Institutes of Health
Kenneth I. Weinberg
Kenneth I. Weinberg Stanford University
Alessandro Aiuti
Alessandro Aiuti Vita-Salute San Raffaele University
Barton F. Haynes
Barton F. Haynes Duke University
Luigi D. Notarangelo
Luigi D. Notarangelo National Institutes of Health

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