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Michael S. Hershfield

Michael S. Hershfield

Duke University
United States

D-Index & Metrics

Biology and Biochemistry

D-Index
84
Citations
19463
World Ranking
3396
National Ranking
1707

Michael S. Hershfield publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Michael S. Hershfield sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 277 publications — 74th percentile

74% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Michael S. Hershfield D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Michael S. Hershfield sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 84 D-Index — 84th percentile

84% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Michael S. Hershfield is affiliated with Duke University in the United States. Their research spans multiple intersecting fields in biomedical sciences with a strong emphasis on immunology, genetics, and molecular biology.

The researcher's main fields of study include Biochemistry, Genetics and Molecular Biology; Medicine; and Immunology and Microbiology. Within these disciplines, key subfields involve Immunology, Genetics, Physiology, Epidemiology, and Molecular Biology.

Major topics covered in their work encompass Immunodeficiency and Autoimmune Disorders, Adenosine and Purinergic Signaling, Cytomegalovirus and herpesvirus research, Virus-based gene therapy research, Biochemical and Molecular Research, Blood disorders and treatments, and CAR-T cell therapy research.

Frequent coauthors collaborating with Michael S. Hershfield include Teresa K. Tarrant, Donald B. Kohn, Theodore B. Moore, Rebecca H. Buckley, and Fabio Candotti.

Their publications are regularly found in these scientific venues: Journal of Clinical Immunology, Frontiers in Immunology, Journal of Allergy and Clinical Immunology, Clinical Immunology, and Blood.

Recent papers showcase a focus on gene therapy and immunodeficiency disorders, highlighting contributions such as:

  • "Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency" (2021), published in New England Journal of Medicine
  • "Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience From India" (2020), published in Arthritis & Rheumatology
  • "Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients" (2021), published in Journal of Clinical Immunology
  • "Evaluation and Management of Deficiency of Adenosine Deaminase 2" (2023), published in JAMA Network Open
  • "Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart" (2022), published in Advanced Science

Michael S. Hershfield has been recognized as a Member of the Association of American Physicians.

Best Publications

  • Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

    Qing Zhou;Dan Yang;Amanda K Ombrello;Andrey V Zavialov

  • Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase.

    M S Hershfield;M S Hershfield;M S Hershfield;R H Buckley;R H Buckley;R H Buckley;M L Greenberg;M L Greenberg;M L Greenberg;A L Melton;A L Melton;A L Melton

  • Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase.

    Nancy J Ganson;Susan J Kelly;Edna Scarlett;John S Sundy

  • T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates

    Kohn Db;Hershfield Ms;Carbonaro D;Shigeoka A

  • Apparent suicide inactivation of human lymphoblast S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine arabinoside. A basis for direct toxic effects of analogs of adenosine.

    M.S. Hershfield

  • Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation.

    Anna E. Denoble;Kim M. Huffman;Thomas V. Stabler;Susan J. Kelly

  • Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer.

    Nancy J. Ganson;Thomas J. Povsic;Bruce A. Sullenger;John H. Alexander

  • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript

    C. G. Begley;P. D. Aplan;M. P. Davey;K. Nakahara

  • Clinical Pharmacogenetics Implementation Consortium Guidelines for Human Leukocyte Antigen-B Genotype and Allopurinol Dosing

    M S Hershfield;J T Callaghan;J T Callaghan;W Tassaneeyakul;T Mushiroda

  • Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase.

    Yael Levy;Michael S. Hershfield;Cristina Fernandez-Mejia;Stephen H. Polmar

  • Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.

    Lawrence R. Finger;Jacob Kagan;George Christopher;Joanne Kurtzberg

  • Gene therapy for adenosine deaminase–deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans

    Fabio Candotti;Kit L. Shaw;Linda Muul;Denise Carbonaro

  • Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation.

    R H Buckley;S E Schiff;H A Sampson;R I Schiff

  • Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout

    John S. Sundy;Nancy J. Ganson;Susan J. Kelly;Edna L. Scarlett

  • Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

    Michael S Hershfield;Nancy J Ganson;Susan J Kelly;Edna L Scarlett

  • How I treat ADA deficiency

    H. Bobby Gaspar;Alessandro Aiuti;Fulvio Porta;Fabio Candotti

  • In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.

    M S Hershfield;N M Kredich;D R Ownby;H Ownby

  • S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity

    Michael S. Hershfield;Nicholas M. Krodich

  • Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin

    Michael S. Hershfield;Joanne Kurtzberg;Elizabeth Harden;Joseph O. Moore

  • CD7+, CD4-, CD8- acute leukemia: a syndrome of malignant pluripotent lymphohematopoietic cells

    Joanne Kurtzberg;Thomas A. Waldmann;Thomas A. Waldmann;Michael P. Davey;Michael P. Davey;Sandra H. Bigner;Sandra H. Bigner

Frequent Co-Authors

Fabio Candotti
Fabio Candotti National Institutes of Health
Joanne Kurtzberg
Joanne Kurtzberg Duke University
Donald B. Kohn
Donald B. Kohn University of California, Los Angeles
Rebecca H. Buckley
Rebecca H. Buckley Duke University
Ivona Aksentijevich
Ivona Aksentijevich National Institutes of Health
Isabelle Meyts
Isabelle Meyts KU Leuven
Kenneth I. Weinberg
Kenneth I. Weinberg Stanford University
Alessandro Aiuti
Alessandro Aiuti Vita-Salute San Raffaele University
Barton F. Haynes
Barton F. Haynes Duke University
Luigi D. Notarangelo
Luigi D. Notarangelo National Institutes of Health

External Links

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Best Scientists Citing Michael S. Hershfield

Donald B. Kohn

Donald B. Kohn

University of California, Los Angeles

Publications: 67

Michael R. Blackburn

Michael R. Blackburn

The University of Texas Health Science Center at Houston

Publications: 66

Alessandro Aiuti

Alessandro Aiuti

Vita-Salute San Raffaele University

Publications: 60

Rebecca H. Buckley

Rebecca H. Buckley

Duke University

Publications: 60

Alain Fischer

Alain Fischer

Collège de France

Publications: 60

Jennifer M. Puck

Jennifer M. Puck

University of California, San Francisco

Publications: 46

Adrian J. Thrasher

Adrian J. Thrasher

University College London

Publications: 46

Marina Cavazzana-Calvo

Marina Cavazzana-Calvo

Necker-Enfants Malades Hospital

Publications: 45

Luigi D. Notarangelo

Luigi D. Notarangelo

National Institutes of Health

Publications: 36

Rodney E. Kellems

Rodney E. Kellems

The University of Texas Health Science Center at Houston

Publications: 34

Fabio Candotti

Fabio Candotti

National Institutes of Health

Publications: 34

Ronald T. Borchardt

Ronald T. Borchardt

University of Kansas

Publications: 29

Andrew R. Gennery

Andrew R. Gennery

Newcastle University

Publications: 28

Maria Grazia Roncarolo

Maria Grazia Roncarolo

Stanford University

Publications: 27

Chaim M. Roifman

Chaim M. Roifman

University of Toronto

Publications: 27

Seza Ozen

Seza Ozen

Hacettepe University

Publications: 25

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