Peter Besmer

Overview

Best Publications

• Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

  Beate Heissig;Koichi Hattori;Sergio Dias;Matthias Friedrich

  2313
  Citations

• The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus.

  Benoit Chabot;Dennis A. Stephenson;Verne M. Chapman;Peter Besmer

  1766
  Citations

• The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.

  Eric Huang;Karl Nocka;David R. Beier;Tang-Yan Chu

  1492
  Citations

• Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation

  Cristina R. Antonescu;Peter Besmer;Tianhua Guo;Knarik Arkun

  978
  Citations

• Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus

  Feihua Qiu;Prabir Ray;K. Brown;P. E. Barker

  850
  Citations

• A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family

  Peter Besmer;John E. Murphy;John E. Murphy;Patricia C. George;Patricia C. George;Feihua Qiu

  842
  Citations

• Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.

  K Nocka;J C Tan;E Chiu;T Y Chu

  714
  Citations

• Gonadal expression of c-kit encoded at the W locus of the mouse

  K. Manova;K. Nocka;P. Besmer;R.F. Bachvarova

  689
  Citations

• Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST).

  Ronald P. DeMatteo;Jason S. Gold;Lisa Saran;Mithat Gönen

  656
  Citations

• Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

  K Nocka;S Majumder;B Chabot;P Ray

  595
  Citations

• Point mutation in Kit receptor tyrosine kinase reveals essential roles for Kit signaling in spermatogenesis and oogenesis without affecting other Kit responses

  Holger Kissel;Inna Timokhina;Inna Timokhina;Matthew P. Hardy;Gerson Rothschild;Gerson Rothschild

  489
  Citations

• Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors

  Narasimhan P. Agaram;Grace C. Wong;Tianhua Guo;Robert G. Maki

  478
  Citations

• The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis

  Peter Besmer;Katia Manova;Regina Duttlinger;Eric J. Huang

  469
  Citations

• Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors.

  Cristina R Antonescu;Gunhild Sommer;Lisa Sarran;Sylvia J Tschernyavsky

  457
  Citations

• Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.

  K. Nocka;J. Buck;E. Levi;P. Besmer

  441
  Citations

• Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

  E J Huang;K H Nocka;J Buck;P Besmer

  411
  Citations

• Kit signaling through PI 3‐kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

  Inna Timokhina;Inna Timokhina;Holger Kissel;Greg Stella;Greg Stella;Peter Besmer;Peter Besmer

  393
  Citations

• The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia.

  K. Manova;E. J. Huang;M. Angeles;V. De Leon

  380
  Citations

• Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature.

  Sonam Prakash;Lisa Sarran;Nicholas Socci;Ronald P DeMatteo

  356
  Citations

• The Dominant W42 Spotting Phenotype Results from a Missense Mutation in the c-kit Receptor Kinase

  Jimmy C. Tan;Karl Nocka;Prabir Ray;Paula Traktman

  344
  Citations