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Tokuo Yamamoto

Tokuo Yamamoto

Overview

Tokuo Yamamoto is affiliated with Tohoku University in Japan. Their research spans several fields within medicine and the biological sciences, with a particular focus on the interplay between metabolism, genetic modification, and clinical applications.

The main fields of study in Yamamoto's work include medicine and biochemistry, genetics, and molecular biology. Their research delves deeper into subfields such as physiology, surgery, molecular biology, and immunology, indicating a multidisciplinary approach to their scientific inquiries.

Themes covered extensively by Yamamoto involve adipose tissue and metabolism, pancreatic function and diabetes, RNA modifications and cancer, immune cell function and interaction, as well as broader topics linking metabolism, diabetes, and cancer. These topics reflect a focus on cellular and molecular processes related to metabolic disorders and immune system interactions.

Yamamoto has contributed to multiple peer-reviewed publications. Notable recent papers include:

  • First-in-human autologous implantation of genetically modified adipocytes expressing LCAT for the treatment of familial LCAT deficiency, 2022, Heliyon
  • First-in-Human Autologous Implantation of Genetically Modified Adipocytes Expressing LCAT for the Treatment of Familial LCAT Deficiency, 2021, SSRN Electronic Journal
  • First-in-Human Autologous Implantation of Genetically Modified Adipocytes Expressing LCAT for the Treatment of Familial LCAT Deficiency, 2021, SSRN Electronic Journal
  • PS13.4: Autologous transplantation of LCAT gene-transduced adipocytes enabled long-term LCAT replacement in a patient with LCAT deficiency in first in human clinical trial., 2025, Transplantation

The venues in which Yamamoto's research has been published most frequently include the SSRN Electronic Journal, Heliyon, and Transplantation.

Collaboration forms a significant component of Yamamoto's scholarly activities. Frequent co-authors in their body of work include Masayuki Aso, Masayuki Kuroda, Jun Wada, Yoshitaka Kubota, and Kunio Yasunaga.

Best Publications

  • The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

    Tokuo Yamamoto;C. Geoffrey Davis;Michael S. Brown;Wolfgang J. Schneider

  • Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

    Sadao Takahashi;Yutaka Kawarabayasi;Tsuguhiko Nakai;Juro Sakai

  • Human Apolipoprotein E Receptor 2 A NOVEL LIPOPROTEIN RECEPTOR OF THE LOW DENSITY LIPOPROTEIN RECEPTOR FAMILY PREDOMINANTLY EXPRESSED IN BRAIN

    Dong Ho Kim;Hiroaki Iijima;Kaoru Goto;Juro Sakai

  • Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter

    Kristina Schoonjans;Mitsuhiro Watanabe;Hiroyuki Suzuki;Abderrahim Mahfoudi

  • Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

    David W. Russell;Wolfgang J. Schneider;Tokuo Yamamoto;Kenneth L. Luskey

  • Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

    Takahiro Fujino;Hiroshi Asaba;Man Jong Kang;Yukio Ikeda

  • Expression of functional acetylcholine receptor from cloned cDNAs

    Masayoshi Mishina;Tomohiro Kurosaki;Takamasa Tobimatsu;Yuuki Morimoto

  • Deletion in Cysteine-Rich Region of LDL Receptor Impedes Transport to Cell Surface in WHHL Rabbit

    Tokuo Yamamoto;Richard W. Bishop;Michael S. Brown;Joseph L. Goldstein

  • Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

    Philip K. Frykman;Michael S. Brown;Tokuo Yamamoto;Joseph L. Goldstein

  • Acetyl-CoA Synthetase 2, a Mitochondrial Matrix Enzyme Involved in the Oxidation of Acetate

    Takahiro Fujino;Jun Kondo;Momoyo Ishikawa;Kosuke Morikawa

  • Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.

    Juro Sakai;Atsushi Hoshino;Sadao Takahashi;Yukio Miura

  • Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family.

    Hideaki Bujo;Marcela Hermann;Michael O. Kaderli;Linda Jacobsen

  • ENHANCEMENT OF THE BINDING OF TRIGLYCERIDE-RICH LIPOPROTEINS TO THE VERY LOW DENSITY LIPOPROTEIN RECEPTOR BY APOLIPOPROTEIN E AND LIPOPROTEIN LIPASE

    Sadao Takahashi;Jinya Suzuki;Mitsuyuki Kohno;Koji Oida

  • Molecular Characterization and Expression of Rat Acyl-CoA Synthetase 3

    Takahiro Fujino;Man-Jong Kang;Hiroyuki Suzuki;Hiroaki Iijima

  • Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease.

    Kaoru Okuizumi;Osamu Onodera;Yoshio Namba;Kazuhiko Ikeda

  • The Very Low-density Lipoprotein (VLDL) Receptor: Characterization and Functions as a Peripheral Lipoprotein Receptor

    Sadao Takahashi;Juro Sakai;Takahiro Fujino;Takahiro Fujino;Hiroaki Hattori

  • cDNA cloning of the bovine low density lipoprotein receptor: Feedback regulation of a receptor mRNA

    David W. Russell;Tokuo Yamamoto;Wolfgang J. Schneider;Clive J. Slaughter

  • c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK

    Shuji Matsuda;Takashi Yasukawa;Yasuko Homma;Yuko Ito

  • Severe Hypercholesterolemia, Impaired Fat Tolerance, and Advanced Atherosclerosis in Mice Lacking Both Low Density Lipoprotein Receptor-related Protein 5 and Apolipoprotein E *

    Kenta Magoori;Man Jong Kang;Mitsuko R. Ito;Hajime Kakuuchi

  • IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis.

    S Takahashi;M Nose;J Sasaki;T Yamamoto

Frequent Co-Authors

Juro Sakai
Juro Sakai University of Tokyo
Walter Wahli
Walter Wahli University of Lausanne
Johan Auwerx
Johan Auwerx École Polytechnique Fédérale de Lausanne
Kristina Schoonjans
Kristina Schoonjans École Polytechnique Fédérale de Lausanne
Joachim Herz
Joachim Herz The University of Texas Southwestern Medical Center
Wolfgang J. Schneider
Wolfgang J. Schneider Medical University of Vienna
Satoru Takahashi
Satoru Takahashi University of Tsukuba
Hiroyuki Toh
Hiroyuki Toh Kwansei Gakuin University
Shinsei Minoshima
Shinsei Minoshima Hamamatsu University
Paul Grimaldi
Paul Grimaldi Université Côte d'Azur

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