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D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
15411
World Ranking
11235
National Ranking
774

Overview

Juro Sakai is affiliated with the University of Tokyo in Japan, contributing extensively to the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their research encompasses several subfields, including Molecular Biology, Physiology, Epidemiology, Cancer Research, and Cell Biology.

Their work addresses key topics related to Adipose Tissue and Metabolism, RNA modifications and cancer, Adipokines, Inflammation, and Metabolic Diseases, Epigenetics and DNA Methylation, Lipid metabolism and biosynthesis, Peroxisome Proliferator-Activated Receptors, and Mitochondrial Function and Pathology.

Juro Sakai has authored various scientific papers, with recent examples illustrating diverse metabolic and molecular biology subjects:

  • "Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content" (2020, Scientific Reports)
  • "Epitranscriptomics in metabolic disease" (2023, Nature Metabolism)
  • "Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever" (2021, eLife)
  • "Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity" (2023, Nucleic Acids Research)
  • "Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors" (2022, Nature Communications)

The scientist frequently publishes in venues that include Nature Communications, SSRN Electronic Journal, Scientific Reports, Nature Metabolism, and iScience. This variety reflects a multi-disciplinary approach within biomedical research.

Collaborative work is notable in their career, with frequent co-authors including Yoshihiro Matsumura, Hiroyuki Aburatani, Tatsuhiko Kodama, Toshiya Tanaka, and Takeshi Yoneshiro.

Best Publications

  • Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

    Toshiya Tanaka;Joji Yamamoto;Satoshi Iwasaki;Hiroshi Asaba

  • Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

    Sadao Takahashi;Yutaka Kawarabayasi;Tsuguhiko Nakai;Juro Sakai

  • Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment.

    Juro Sakai;Elizabeth A Duncan;Robert B Rawson;Xianxin Hua

  • Complementation Cloning of S2P, a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs

    Robert B. Rawson;Nikolai G. Zelenski;Deepak Nijhawan;Jin Ye

  • Human Apolipoprotein E Receptor 2 A NOVEL LIPOPROTEIN RECEPTOR OF THE LOW DENSITY LIPOPROTEIN RECEPTOR FAMILY PREDOMINANTLY EXPRESSED IN BRAIN

    Dong Ho Kim;Hiroaki Iijima;Kaoru Goto;Juro Sakai

  • Molecular Identification of the Sterol-Regulated Luminal Protease that Cleaves SREBPs and Controls Lipid Composition of Animal Cells

    Juro Sakai;Robert B Rawson;Peter J Espenshade;Dong Cheng

  • Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

    Takahiro Fujino;Hiroshi Asaba;Man Jong Kang;Yukio Ikeda

  • Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

    Xiaodong Wang;Nikolai G. Zelenski;Jianxin Yang;Juro Sakai

  • cDNA Cloning of Mouse and Human Cholesterol 25-Hydroxylases, Polytopic Membrane Proteins That Synthesize a Potent Oxysterol Regulator of Lipid Metabolism

    Erik G. Lund;Thomas A. Kerr;Juro Sakai;Wei Ping Li

  • Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.

    Juro Sakai;Atsushi Hoshino;Sadao Takahashi;Yukio Miura

  • Transcriptional and epigenetic control of brown and beige adipose cell fate and function

    Takeshi Inagaki;Juro Sakai;Shingo Kajimura

  • A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

    Shinji Kamisuki;Qian Mao;Lutfi Abu-Elheiga;Ziwei Gu

  • Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein

    Juro Sakai;Axel Nohturfft;Dong Cheng;Y. K. Ho

  • Angiopoietin-related growth factor antagonizes obesity and insulin resistance

    Yuichi Oike;Masaki Akao;Kunio Yasunaga;Toshimasa Yamauchi

  • Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies.

    Juro Sakai;Axel Nohturfft;Joseph L. Goldstein;Michael S. Brown

  • Regulated Cleavage of Sterol Regulatory Element Binding Proteins Requires Sequences on Both Sides of the Endoplasmic Reticulum Membrane

    Xianxin Hua;Juro Sakai;Michael S. Brown;Joseph L. Goldstein

  • The Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor α Heterodimer Targets the Histone Modification Enzyme PR-Set7/Setd8 Gene and Regulates Adipogenesis through a Positive Feedback Loop

    Ken Ichi Wakabayashi;Masashi Okamura;Shuichi Tsutsumi;Naoko S. Nishikawa

  • Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A

    Imari Mimura;Masaomi Nangaku;Yasuharu Kanki;Shuichi Tsutsumi

  • Cleavage Site for Sterol-regulated Protease Localized to a Leu-Ser Bond in the Lumenal Loop of Sterol Regulatory Element-binding Protein-2

    Elizabeth A. Duncan;Michael S. Brown;Joseph L. Goldstein;Juro Sakai

  • COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis

    Masashi Okamura;Hiromi Kudo;Ken Ichi Wakabayashi;Toshiya Tanaka

Frequent Co-Authors

Tatsuhiko Kodama
Tatsuhiko Kodama University of Tokyo
Takao Hamakubo
Takao Hamakubo Nippon Medical School
Hiroyuki Aburatani
Hiroyuki Aburatani University of Tokyo
Makoto Naito
Makoto Naito Niigata University
Timothy F. Osborne
Timothy F. Osborne Johns Hopkins University School of Medicine
Michael S. Brown
Michael S. Brown The University of Texas Southwestern Medical Center
Joseph L. Goldstein
Joseph L. Goldstein The University of Texas Southwestern Medical Center
Masashi Yanagisawa
Masashi Yanagisawa University of Tsukuba
Shuichi Tsutsumi
Shuichi Tsutsumi University of Tokyo
Motonobu Anai
Motonobu Anai University of Tokyo

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