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Takao Hamakubo

Takao Hamakubo

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
18336
World Ranking
6307
National Ranking
409

Overview

Takao Hamakubo is affiliated with Nippon Medical School in Japan and has a research focus at the intersection of medicine, biochemistry, genetics, and molecular biology. Their work spans several subfields including molecular biology, oncology, radiology, nuclear medicine and imaging, immunology, as well as pulmonary and respiratory medicine.

The research topics covered by Hamakubo emphasize monoclonal and polyclonal antibodies research, neuroblastoma research and treatments, photodynamic therapy research studies, lung cancer research studies, neuroendocrine tumor research advances, RNA research and splicing, and RNA modifications in cancer.

The scientist has published a considerable number of papers, including notable recent contributions such as:

  • Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas (2020, Cancer Research)
  • NRF3-POMP-20S Proteasome Assembly Axis Promotes Cancer Development via Ubiquitin-Independent Proteolysis of p53 and Retinoblastoma Protein (2020, Molecular and Cellular Biology)
  • Wilms' tumor 1-associating protein complex regulates alternative splicing and polyadenylation at potential G-quadruplex-forming splice site sequences (2021, Journal of Biological Chemistry)
  • Increased Pentraxin 3 Levels Correlate With IVIG Responsiveness and Coronary Artery Aneurysm Formation in Kawasaki Disease (2021, Frontiers in Immunology)
  • Generation of biparatopic antibody through two-step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher (2020, Biotechnology Reports)

Frequent publication venues for Hamakubo include:

  • Cancer Research
  • Nature Communications
  • Nuclear Medicine Communications
  • Journal of Biological Chemistry
  • Molecular and Cellular Biology

Collaboration forms an important component of Hamakubo's research activities. Frequent coauthors include Kenji Daigo, Hiroko Iwanari, Riuko Ohashi, and Noriko Komatsu, each appearing in multiple publications with Hamakubo.

Best Publications

  • Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

    Toshiya Tanaka;Joji Yamamoto;Satoshi Iwasaki;Hiroshi Asaba

  • Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.

    Makoto Tachibana;Jun Ueda;Mikiko Fukuda;Naoki Takeda

  • Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

    Y Kambayashi;S Bardhan;K Takahashi;S Tsuzuki

  • Identification of Soluble NH2-Terminal Fragment of Glypican-3 as a Serological Marker for Early-Stage Hepatocellular Carcinoma

    Yoshitaka Hippo;Kiyotaka Watanabe;Akira Watanabe;Yutaka Midorikawa

  • Scavenger receptor family proteins: roles for atherosclerosis, host defence and disorders of the central nervous system.

    Y Yamada;T Doi;T Hamakubo;T Kodama

  • G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody

    Tomoya Hino;Takatoshi Arakawa;Hiroko Iwanari;Takami Yurugi-Kobayashi

  • Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle

    Keiko Horiuchi;Takeshi Kawamura;Hiroko Iwanari;Riuko Ohashi

  • Establishment of a High Sensitivity Plasma Assay for Human Pentraxin3 as a Marker for Unstable Angina Pectoris

    Kenji Inoue;Akira Sugiyama;Patrick C. Reid;Yukio Ito

  • A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants

    Shinya Aramaki;Katsuhiko Hayashi;Kazuki Kurimoto;Hiroshi Ohta

  • The Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor α Heterodimer Targets the Histone Modification Enzyme PR-Set7/Setd8 Gene and Regulates Adipogenesis through a Positive Feedback Loop

    Ken Ichi Wakabayashi;Masashi Okamura;Shuichi Tsutsumi;Naoko S. Nishikawa

  • Crystal structure of the anion exchanger domain of human erythrocyte band 3

    Takatoshi Arakawa;Takami Kobayashi-Yurugi;Yilmaz Alguel;Hiroko Iwanari

  • Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A

    Imari Mimura;Masaomi Nangaku;Yasuharu Kanki;Shuichi Tsutsumi

  • Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions

    AS Savchenko;M Imamura;R Ohashi;S Jiang

  • Distribution of calpains I and II in rat brain.

    T Hamakubo;R Kannagi;T Murachi;A Matus

  • Vascular Endothelial Growth Factor- and Thrombin-induced Termination Factor, Down Syndrome Critical Region-1, Attenuates Endothelial Cell Proliferation and Angiogenesis

    Takashi Minami;Keiko Horiuchi;Mai Miura;Md. Ruhul Abid

  • The Effect of Statins on mRNA Levels of Genes Related to Inflammation, Coagulation, and Vascular Constriction in HUVEC

    Shigeru Morikawa;Wakako Takabe;Chikage Mataki;Toru Kanke

  • Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95

    Jun Noritake;Yuko Fukata;Tsuyoshi Iwanaga;Naoki Hosomi

  • Structure and mechanism of the mammalian fructose transporter GLUT5

    Norimichi Nomura;Grégory Verdon;Hae Joo Kang;Hae Joo Kang;Tatsuro Shimamura

  • A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-acetate differentiated THP-1 cells and human monocyte-derived macrophage.

    Takahide Kohro;Toshiya Tanaka;Takeshi Murakami;Yoichiro Wada

  • COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis

    Masashi Okamura;Hiromi Kudo;Ken Ichi Wakabayashi;Toshiya Tanaka

Frequent Co-Authors

Tatsuhiko Kodama
Tatsuhiko Kodama University of Tokyo
Hiroyuki Aburatani
Hiroyuki Aburatani University of Tokyo
Makoto Naito
Makoto Naito Niigata University
Juro Sakai
Juro Sakai University of Tokyo
Kouhei Tsumoto
Kouhei Tsumoto University of Tokyo
Noriko Noguchi
Noriko Noguchi Doshisha University
Shuichi Tsutsumi
Shuichi Tsutsumi University of Tokyo
Tohru Kozasa
Tohru Kozasa University of Illinois at Chicago
Taisuke Tomita
Taisuke Tomita University of Tokyo
Shigeru Morikawa
Shigeru Morikawa National Institutes of Health

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