World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Biology and Biochemistry
USA
2026

D-Index & Metrics

Best Scientists

D-Index
210
Citations
165749
World Ranking
199
National Ranking
131

Biology and Biochemistry

D-Index
213
Citations
171964
World Ranking
24
National Ranking
21

Medicine

D-Index
213
Citations
172052
World Ranking
120
National Ranking
81

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2026 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Medicine in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award

Overview

Frank J. Gonzalez is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, encompassing 256 and 200 publications respectively. Within these domains, they have focused extensively on subfields such as Molecular Biology, Epidemiology, Oncology, Pharmacology, and Physiology.

The main research topics addressed by Gonzalez include:

  • Liver Disease Diagnosis and Treatment
  • Peroxisome Proliferator-Activated Receptors
  • Drug Transport and Resistance Mechanisms
  • Cancer, Hypoxia, and Metabolism
  • Gut microbiota and health
  • Diet, Metabolism, and Disease
  • Pharmacogenetics and Drug Metabolism

Gonzalez has published across a range of scientific venues, with frequent contributions to:

  • Value in Health
  • Nature Communications
  • The FASEB Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Hepatology

Some recent publications by Gonzalez include:

  • Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis, 2022, Cell Host & Microbe
  • PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice, 2020, International Journal of Molecular Sciences
  • The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer, 2021, Nature Reviews Gastroenterology & Hepatology
  • Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice, 2023, Nature Communications
  • Gut bacteria alleviate smoking-related NASH by degrading gut nicotine, 2022, Nature

Frequent coauthors in Gonzalez's research include:

  • Kristopher W. Krausz
  • Shogo Takahashi
  • Lulu Sun
  • Yuhong Luo
  • Cen Xie

Best Publications

  • Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

    Sander Kersten;Josiane Seydoux;Jeffrey M. Peters;Frank J. Gonzalez

  • Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

    Christopher J Sinal;Masahiro Tohkin;Masaaki Miyata;Jerrold M Ward

  • C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.

    Evan D. Rosen;Chung-Hsin Hsu;Xinzhong Wang;Shuichi Sakai

  • Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

    Huafeng Zhang;Marta Bosch-Marce;Larissa A. Shimoda;Yee Sun Tan

  • The PPARalpha-leukotriene B4 pathway to inflammation control.

    Pallavi R. Devchand;Hansjörg Keller;Jeffrey Maurice Peters;Manuel Vazquez

  • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.

    S S Lee;T Pineau;J Drago;E J Lee

  • Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer

    Daniel W. Nebert;Timothy P. Dalton;Allan B. Okey;Frank J. Gonzalez

  • Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

    Pedro Fernandez-Salguero;Thierry Pineau;David M. Hilbert;Timothy McPhail

  • Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

    Philippe Delerive;Karolien De Bosscher;Sandrine Besnard;Wim Vanden Berghe

  • Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.

    Graham P. Hayhurst;Ying-Hue Lee;Gilles Lambert;Jerrold M. Ward

  • International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors

    Liliane Michalik;Johan Auwerx;Joel P. Berger;V. Krishna Chatterjee

  • Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)

    Toshifumi Aoyama;Jeffrey M. Peters;Nobuko Iritani;Tamie Nakajima

  • Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity

    Pedro M. Fernandez-Salguero;David M. Hilbert;Stuart Rudikoff;Jerrold M. Ward

  • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

    Isabelle A. Leclercq;Geoffrey C. Farrell;Jaqueline Field;David R. Bell

  • Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.

    F J Gonzalez;R C Skoda;S Kimura;M Umeno

  • Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass

    Oksana Gavrilova;Martin Haluzik;Kimihiko Matsusue;Jaime J. Cutson

  • The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

    Daniel W. Nebert;David R. Nelson;Milton Adesnik;Minor J. Coon

  • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

    Yanqiao Zhang;Florence Ying Lee;Gabriel Barrera;Hans Lee

  • Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis

    James Rhee;Yusuke Inoue;J. Cliff Yoon;Pere Puigserver

  • Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.

    Lulu Sun;Cen Xie;Guang Wang;Yue Wu

Frequent Co-Authors

Kristopher W. Krausz
Kristopher W. Krausz National Institutes of Health
Jeffrey M. Peters
Jeffrey M. Peters Pennsylvania State University
Jeffrey R. Idle
Jeffrey R. Idle University of Bern
Harry V. Gelboin
Harry V. Gelboin National Institutes of Health
Andrew D. Patterson
Andrew D. Patterson Pennsylvania State University
Yatrik M. Shah
Yatrik M. Shah University of Michigan–Ann Arbor
Shioko Kimura
Shioko Kimura National Institutes of Health
Pedro M. Fernandez-Salguero
Pedro M. Fernandez-Salguero University of Extremadura
Daniel W. Nebert
Daniel W. Nebert University of Cincinnati
Jerrold M. Ward
Jerrold M. Ward National Institutes of Health

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