World's Best Scientists 2026 revealed!
F. Peter Guengerich

F. Peter Guengerich

Award Badge
Biology and Biochemistry
USA
2026
Award Badge
Chemistry
USA
2026

D-Index & Metrics

Chemistry

D-Index
163
Citations
103493
World Ranking
90
National Ranking
48

Biology and Biochemistry

D-Index
164
Citations
107431
World Ranking
106
National Ranking
81

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2026 - Research.com Chemistry in United States Leader Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Chemistry in United States Leader Award
  • 2009 - Fellow of the American Chemical Society
  • 1997 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

F. Peter Guengerich is affiliated with Vanderbilt University in the United States and has contributed extensively to the fields of biochemistry, molecular biology, pharmacology, toxicology, and medicine. Their research primarily focuses on pharmacogenetics and drug metabolism, drug transport and resistance mechanisms, and cancer treatment and pharmacology, with additional attention to carcinogens and genotoxicity assessment, DNA repair mechanisms, agricultural safety and regulations, and metal-catalyzed oxygenation mechanisms.

The scientist's frequent publication venues include:

  • Journal of Biological Chemistry
  • Food and Chemical Toxicology
  • Chemical Research in Toxicology
  • Xenobiotica
  • Archives of Biochemistry and Biophysics

Among recent papers, notable works include:

  • "Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications" (2020, Journal of Biological Chemistry)
  • "A history of the roles of cytochrome P450 enzymes in the toxicity of drugs" (2020, Toxicological Research)
  • "Cytochrome P450 2E1 and its roles in disease" (2020, Chemico-Biological Interactions)
  • "Human Family 1-4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update" (2021, Archives of Toxicology)
  • "Inhibition of Cytochrome P450 Enzymes by Drugs-Molecular Basis and Practical Applications" (2021, Biomolecules & Therapeutics)

Frequent co-authors collaborating with F. Peter Guengerich include:

  • Lila M. Gierasch
  • Ruma Banerjee
  • Roger Colbran
  • Peter Cresswell
  • George Demartino

The scientist's expertise spans multiple subfields of study, with emphasis on:

  • Pharmacology
  • Molecular Biology
  • Oncology
  • Food Science
  • Cancer Research

F. Peter Guengerich has been recognized with professional honors including being named a Fellow of the American Chemical Society in 2009 and a Fellow of the American Association for the Advancement of Science (AAAS) in 1997.

Best Publications

  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

    T Shimada;H Yamazaki;M Mimura;Y Inui

  • The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.

    D R Nelson;T Kamataki;D J Waxman;F P Guengerich

  • Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.

    F. Peter Guengerich

  • Cytochrome P450 and Chemical Toxicology

    F. Peter Guengerich

  • Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

    F. P. Guengerich;Dong-Hyun Kim;M. Iwasaki

  • Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone.

    F. Peter Guengerich;Ghazi A. Dannan;S. Tracy Wright;Martha V. Martin

  • The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.

    D W Nebert;D R Nelson;M J Coon;R W Estabrook

  • Cytochrome P-450 3A4: regulation and role in drug metabolism.

    Unknown

  • Mapping the Genetic Architecture of Gene Expression in Human Liver

    Eric E. Schadt;Cliona Molony;Eugene Chudin;Ke-Ke Hao

  • Human Cytochrome P450 Enzymes

    F. Peter Guengerich

  • Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes.

    Unknown

  • Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1

    Tsutomu Shimada;Carrie L. Hayes;Hiroshi Yamazaki;Shantu Amin

  • Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

    F P Guengerich;M V Martin;P H Beaune;P Kremers

  • The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

    Daniel W. Nebert;David R. Nelson;Milton Adesnik;Minor J. Coon

  • Cytochrome P450s and other enzymes in drug metabolism and toxicity.

    F. Peter Guengerich

  • Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat.

    Ronald A. Lubet;Richard T. Mayer;John W. Cameron;Raymond W. Nims

  • Chemical mechanisms of catalysis by cytochromes P-450: a unified view

    F. Peter Guengerich;Timothy L. Macdonald

  • Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

    Raimund Peter;Ronald Boecker;Philippe H. Beaune;Masahiko Iwasaki

  • Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

    D J Waxman;G A Dannan;F P Guengerich

  • Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

    F. Peter Guengerich

  • Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics.

    C. J. Patten;P. E. Thomas;R. L. Guy;Maojung Lee

  • Complex reactions catalyzed by cytochrome P450 enzymes.

    Emre M. Isin;F. Peter Guengerich

Frequent Co-Authors

Hiroshi Yamazaki
Hiroshi Yamazaki Showa Pharmaceutical University
Tsutomu Shimada
Tsutomu Shimada Osaka Metropolitan University
Martin Egli
Martin Egli Vanderbilt University
Stephen S. Hecht
Stephen S. Hecht University of Minnesota
Elizabeth M. J. Gillam
Elizabeth M. J. Gillam University of Queensland
Michael R. Waterman
Michael R. Waterman Vanderbilt University
Thomas M. Harris
Thomas M. Harris Vanderbilt University
Chul-Ho Yun
Chul-Ho Yun Chonnam National University
Lawrence J. Marnett
Lawrence J. Marnett Vanderbilt University
Norio Shibata
Norio Shibata Nagoya Institute of Technology

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in expanding their expertise beyond traditional chemistry, there are several related online degree options that open doors to diverse career opportunities. For example, pursuing an online masters forensic psychology degree can complement a chemistry background, particularly for those fascinated by the intersection of science and law enforcement.

Careers in forensic science offer a dynamic pathway for chemists aiming to apply their skills in criminal investigations. Exploring forensic career paths reveals roles in crime labs, toxicology, and evidence analysis that rely heavily on chemical principles.

Understanding cost is crucial when considering further education. Resources discussing criminal justice degree cost provide valuable insights into budgeting for online programs that combine chemistry, forensic science, and legal studies.

For those beginning their academic journey or seeking flexible entry points, an online associates in criminal justice can be a practical choice, laying the foundation for advanced degrees that integrate chemistry with criminal justice disciplines.

Best Scientists Citing F. Peter Guengerich

Trending Scientists