D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 89 Citations 30,384 377 World Ranking 863 National Ranking 384
Biology and Biochemistry D-index 99 Citations 36,780 473 World Ranking 709 National Ranking 452

Research.com Recognitions

Awards & Achievements

2009 - Fellow of the American Chemical Society

1997 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Biochemistry

His primary areas of investigation include Biochemistry, Cytochrome P450, Microsome, Enzyme and Stereochemistry. His is involved in several facets of Biochemistry study, as is seen by his studies on Carcinogen, Cytochrome, Reductase, Hydroxylation and Heme. F. Peter Guengerich combines subjects such as Xenobiotic, Pharmacology and Drug metabolism with his study of Cytochrome P450.

The Microsome study combines topics in areas such as Gene expression, Glutathione, Metabolite, Cytochrome P-450 CYP3A and Enzyme inhibitor. The various areas that F. Peter Guengerich examines in his Enzyme study include Indole test, Mutagenesis and Messenger RNA. His Stereochemistry research is multidisciplinary, incorporating perspectives in Quinoline, Cooperativity, Anthracene, Active site and Binding site.

His most cited work include:

  • The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature (1464 citations)
  • Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. (1229 citations)
  • Cytochrome P450 and Chemical Toxicology (1093 citations)

What are the main themes of his work throughout his whole career to date?

F. Peter Guengerich spends much of his time researching Biochemistry, Cytochrome P450, Enzyme, Stereochemistry and Microsome. DNA, Metabolism, Cytochrome, Carcinogen and DNA polymerase are the core of his Biochemistry study. F. Peter Guengerich works mostly in the field of Cytochrome P450, limiting it down to topics relating to Pharmacology and, in certain cases, Thalidomide.

His study in Enzyme focuses on Xenobiotic in particular. His work deals with themes such as Active site, Catalysis, Epoxide and Substrate, Enzyme kinetics, which intersect with Stereochemistry. His research in Microsome intersects with topics in Metabolite, Monooxygenase and Isozyme.

He most often published in these fields:

  • Biochemistry (53.31%)
  • Cytochrome P450 (31.84%)
  • Enzyme (27.81%)

What were the highlights of his more recent work (between 2014-2021)?

  • Biochemistry (53.31%)
  • Cytochrome P450 (31.84%)
  • Enzyme (27.81%)

In recent papers he was focusing on the following fields of study:

F. Peter Guengerich focuses on Biochemistry, Cytochrome P450, Enzyme, Stereochemistry and DNA polymerase. His works in Metabolism, DNA repair, Active site, Oxidoreductase and Cholesterol are all subjects of inquiry into Biochemistry. The concepts of his Cytochrome P450 study are interwoven with issues in Drug metabolism, Oxidative phosphorylation, Substrate, Enzyme kinetics and Heme.

His research investigates the connection between Enzyme and topics such as Pharmacology that intersect with issues in Toxicity and In vivo. His Stereochemistry research incorporates elements of Electrophile, Bond cleavage, Catalysis, Hydroxylation and Lyase. His DNA polymerase research also works with subjects such as

  • Polymerase, which have a strong connection to Molecular biology,
  • DNA clamp, which have a strong connection to DNA polymerase II.

Between 2014 and 2021, his most popular works were:

  • Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals. (170 citations)
  • Recent Structural Insights into Cytochrome P450 Function. (111 citations)
  • Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis. (101 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • DNA

His primary scientific interests are in Biochemistry, Cytochrome P450, Enzyme, Stereochemistry and DNA damage. His work in Polymerase, DNA polymerase, Cholesterol, DNA repair and Lanosterol are all subfields of Biochemistry research. His Cytochrome P450 research incorporates themes from Radical, Enzyme kinetics, Drug metabolism and Active site.

His research investigates the connection with Enzyme and areas like Metabolism which intersect with concerns in Vitamin D and neurology, Enzyme inducer and Monoamine oxidase. His work carried out in the field of Stereochemistry brings together such families of science as Peroxidase, Steroid, Lyase and Bond cleavage. His DNA damage research is multidisciplinary, incorporating elements of Metabolite, Multiple myeloma and Antiemetic.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

D R Nelson;T Kamataki;D J Waxman;F P Guengerich.
DNA and Cell Biology (1993)

2152 Citations

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.

F. Peter Guengerich.
Chemical Research in Toxicology (2001)

1882 Citations

Cytochrome P450 and Chemical Toxicology

F. Peter Guengerich.
Chemical Research in Toxicology (2008)

1611 Citations

Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone.

F. Peter Guengerich;Ghazi A. Dannan;S. Tracy Wright;Martha V. Martin.
Biochemistry (1982)

1500 Citations

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.

D W Nebert;D R Nelson;M J Coon;R W Estabrook.
DNA and Cell Biology (1991)

1392 Citations

Human cytochrome P-450 enzymes.

F. Peter Guengerich.
Life Sciences (1992)

1141 Citations

Mapping the Genetic Architecture of Gene Expression in Human Liver

Eric E. Schadt;Cliona Molony;Eugene Chudin;Ke-Ke Hao.
PLOS Biology (2008)

1095 Citations

The P450 gene superfamily: recommended nomenclature.

Nebert Dw;Adesnik M;Coon Mj;Estabrook Rw.
DNA (Mary Ann Liebert, Inc.) (1987)

1012 Citations

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1

Tsutomu Shimada;Carrie L. Hayes;Hiroshi Yamazaki;Shantu Amin.
Cancer Research (1996)

984 Citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

Daniel W. Nebert;David R. Nelson;Milton Adesnik;Minor J. Coon.
DNA (Mary Ann Liebert, Inc.) (1989)

816 Citations

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