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Tsutomu Shimada

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
29469
World Ranking
2694
National Ranking
165

Tsutomu Shimada publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Tsutomu Shimada sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 264 publications — 71st percentile

71% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Tsutomu Shimada D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Tsutomu Shimada sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 88 D-Index — 87th percentile

87% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Tsutomu Shimada is affiliated with Osaka Metropolitan University in Japan and has contributed extensively to research primarily in the field of Medicine. Their work spans several subfields including Pharmacology, Molecular Biology, Pathology and Forensic Medicine, Oncology, and Pulmonary and Respiratory Medicine.

The main topics of Tsutomu Shimada's research include Pharmacogenetics and Drug Metabolism, Flavonoids in Medical Research, Phytoestrogen effects and research, Drug Transport and Resistance Mechanisms, Chromatography in Natural Products, Advancements in Transdermal Drug Delivery, and Systemic Sclerosis and Related Diseases.

They have published in various scientific journals, with frequent publications in:

  • Xenobiotica
  • Journal of Pharmaceutical Health Care and Sciences
  • The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec)
  • In Vivo
  • Chemical Research in Toxicology

Tsutomu Shimada's recent papers include:

  • Preference for O-demethylation reactions in the oxidation of 2'-, 3'-, and 4'-methoxyflavones by human cytochrome P450 enzymes, 2020, Xenobiotica
  • Risk Factors for Delayed Elimination of Methotrexate in Children, Adolescents and Young Adults With Osteosarcoma, 2020, In Vivo
  • Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers, 2022, Pharmaceutical Research
  • Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1, 2023, Chemical Research in Toxicology
  • Roles of cytochrome P450 2A6 in the oxidation of flavone, 4'-hydroxyflavone, and 4'-, 3'-, and 2'-methoxyflavones by human liver microsomes, 2021, Xenobiotica

The scientist frequently collaborates with other researchers, including Yoshimichi Sai, Arimi Fujita, Haruna Nagayoshi, Norie Murayama, and Vitchan Kim.

Best Publications

  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

    T Shimada;H Yamazaki;M Mimura;Y Inui

  • Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1

    Tsutomu Shimada;Carrie L. Hayes;Hiroshi Yamazaki;Shantu Amin

  • Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1

    Tsutomu Shimada;Yoshiaki Fujii-Kuriyama

  • Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

    H. Yamazaki;Y. Inui;Chul-Ho Yun;F. P. Guengerich

  • Activation and detoxication of aflatoxin B1

    Guengerich Fp;Johnson Ww;Shimada T;Ueng Yf

  • Catalytic properties of polymorphic human cytochrome P450 1B1 variants

    Tsutomu Shimada;Junko Watanabe;Kaname Kawajiri;Thomas R. Sutter

  • Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes.

    Hiroshi Yamazaki;Tsutomu Shimada

  • Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

    Shimada T;Iwasaki M;Martin Mv;Guengerich Fp

  • Purification and characterization of human liver microsomal cytochrome P-450 2A6.

    Chul-Ho Yun;T. Shimada;F. P. Guengerich

  • Activation of procarcinogens by human cytochrome P450 enzymes

    F P Guengerich;T Shimada

  • Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

    T Shimada;K S Misono;F P Guengerich

  • Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.

    T. Shimada;H. Yamazaki;M. Mimura;N. Wakamiya

  • Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.

    T. Shimada;Chul-Ho Yun;H. Yamazaki;J.-C. Gautier

  • Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.

    Shimada T;Martin Mv;Pruess-Schwartz D;Marnett Lj

  • Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice.

    Tsutomu Shimada;Kiyoshi Inoue;Yoshihiko Suzuki;Takao Kawai

  • SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals.

    Sei-ichi Nakamura;Yoshimitsu Oda;Tsutomu Shimada;Iwashiro Oki

  • Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.

    Shimada T;Oda Y;Gillam Em;Guengerich Fp

  • Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes.

    Yune-Fang Ueng;T. Shimada;H. Yamazaki;F. P. Guengerich

  • Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.

    Hiroshi Yamazaki;Mami Nakamura;Tomoko Komatsu;Katsuhiro Ohyama

  • Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1.

    Shimada T;Yamazaki H;Foroozesh M;Hopkins Ne

Frequent Co-Authors

Hiroshi Yamazaki
Hiroshi Yamazaki Showa Pharmaceutical University
F. Peter Guengerich
F. Peter Guengerich Vanderbilt University
Elizabeth M. J. Gillam
Elizabeth M. J. Gillam University of Queensland
Yoshihiko Funae
Yoshihiko Funae Osaka Metropolitan University
Susumu Imaoka
Susumu Imaoka Kwansei Gakuin University
Chul-Ho Yun
Chul-Ho Yun Chonnam National University
Thomas M. Harris
Thomas M. Harris Vanderbilt University
Thomas R. Sutter
Thomas R. Sutter University of Memphis
Tetsuya Kamataki
Tetsuya Kamataki Hokkaido University
Takehiko Nohmi
Takehiko Nohmi Gifu University

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Best Scientists Citing Tsutomu Shimada

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