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Biology and Biochemistry

D-Index
88
Citations
29469
World Ranking
2694
National Ranking
165

Overview

Tsutomu Shimada is affiliated with Osaka Metropolitan University in Japan and has contributed extensively to research primarily in the field of Medicine. Their work spans several subfields including Pharmacology, Molecular Biology, Pathology and Forensic Medicine, Oncology, and Pulmonary and Respiratory Medicine.

The main topics of Tsutomu Shimada's research include Pharmacogenetics and Drug Metabolism, Flavonoids in Medical Research, Phytoestrogen effects and research, Drug Transport and Resistance Mechanisms, Chromatography in Natural Products, Advancements in Transdermal Drug Delivery, and Systemic Sclerosis and Related Diseases.

They have published in various scientific journals, with frequent publications in:

  • Xenobiotica
  • Journal of Pharmaceutical Health Care and Sciences
  • The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec)
  • In Vivo
  • Chemical Research in Toxicology

Tsutomu Shimada's recent papers include:

  • Preference for O-demethylation reactions in the oxidation of 2'-, 3'-, and 4'-methoxyflavones by human cytochrome P450 enzymes, 2020, Xenobiotica
  • Risk Factors for Delayed Elimination of Methotrexate in Children, Adolescents and Young Adults With Osteosarcoma, 2020, In Vivo
  • Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers, 2022, Pharmaceutical Research
  • Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1, 2023, Chemical Research in Toxicology
  • Roles of cytochrome P450 2A6 in the oxidation of flavone, 4'-hydroxyflavone, and 4'-, 3'-, and 2'-methoxyflavones by human liver microsomes, 2021, Xenobiotica

The scientist frequently collaborates with other researchers, including Yoshimichi Sai, Arimi Fujita, Haruna Nagayoshi, Norie Murayama, and Vitchan Kim.

Best Publications

  • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

    T Shimada;H Yamazaki;M Mimura;Y Inui

  • Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1

    Tsutomu Shimada;Carrie L. Hayes;Hiroshi Yamazaki;Shantu Amin

  • Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1

    Tsutomu Shimada;Yoshiaki Fujii-Kuriyama

  • Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

    H. Yamazaki;Y. Inui;Chul-Ho Yun;F. P. Guengerich

  • Activation and detoxication of aflatoxin B1

    Guengerich Fp;Johnson Ww;Shimada T;Ueng Yf

  • Catalytic properties of polymorphic human cytochrome P450 1B1 variants

    Tsutomu Shimada;Junko Watanabe;Kaname Kawajiri;Thomas R. Sutter

  • Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes.

    Hiroshi Yamazaki;Tsutomu Shimada

  • Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

    Shimada T;Iwasaki M;Martin Mv;Guengerich Fp

  • Purification and characterization of human liver microsomal cytochrome P-450 2A6.

    Chul-Ho Yun;T. Shimada;F. P. Guengerich

  • Activation of procarcinogens by human cytochrome P450 enzymes

    F P Guengerich;T Shimada

  • Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

    T Shimada;K S Misono;F P Guengerich

  • Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.

    T. Shimada;H. Yamazaki;M. Mimura;N. Wakamiya

  • Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens.

    T. Shimada;Chul-Ho Yun;H. Yamazaki;J.-C. Gautier

  • Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.

    Shimada T;Martin Mv;Pruess-Schwartz D;Marnett Lj

  • Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice.

    Tsutomu Shimada;Kiyoshi Inoue;Yoshihiko Suzuki;Takao Kawai

  • SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals.

    Sei-ichi Nakamura;Yoshimitsu Oda;Tsutomu Shimada;Iwashiro Oki

  • Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.

    Shimada T;Oda Y;Gillam Em;Guengerich Fp

  • Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes.

    Yune-Fang Ueng;T. Shimada;H. Yamazaki;F. P. Guengerich

  • Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.

    Hiroshi Yamazaki;Mami Nakamura;Tomoko Komatsu;Katsuhiro Ohyama

  • Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1.

    Shimada T;Yamazaki H;Foroozesh M;Hopkins Ne

Frequent Co-Authors

Hiroshi Yamazaki
Hiroshi Yamazaki Showa Pharmaceutical University
F. Peter Guengerich
F. Peter Guengerich Vanderbilt University
Elizabeth M. J. Gillam
Elizabeth M. J. Gillam University of Queensland
Yoshihiko Funae
Yoshihiko Funae Osaka Metropolitan University
Susumu Imaoka
Susumu Imaoka Kwansei Gakuin University
Chul-Ho Yun
Chul-Ho Yun Chonnam National University
Thomas M. Harris
Thomas M. Harris Vanderbilt University
Thomas R. Sutter
Thomas R. Sutter University of Memphis
Tetsuya Kamataki
Tetsuya Kamataki Hokkaido University
Takehiko Nohmi
Takehiko Nohmi Gifu University

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