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Biology and Biochemistry

D-Index
65
Citations
15175
World Ranking
9147
National Ranking
67

Overview

Hannu Raunio is affiliated with the University of Eastern Finland in Finland. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Pharmacology, Toxicology and Pharmaceutics. The scientist's work engages closely with areas such as Pharmacology, Molecular Biology, and Oncology, alongside specialized domains like Spectroscopy and Organic Chemistry.

Their research topics include:

  • Pharmacogenetics and Drug Metabolism
  • Drug Transport and Resistance Mechanisms
  • Analytical Chemistry and Chromatography
  • Synthesis and Biological Evaluation
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Inflammatory mediators and NSAID effects
  • Sulfur Compounds in Biology

Hannu Raunio's publications include recent papers such as:

  • "Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro", 2020, International Journal of Molecular Sciences
  • "Inhibition of human CYP1 enzymes by a classical inhibitor α-naphthoflavone and a novel inhibitor N-(3, 5-dichlorophenyl)cyclopropanecarboxamide: An in vitro and in silico study", 2020, Chemical Biology & Drug Design
  • "Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling", 2021, ACS Omega
  • "Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13", 2021, Xenobiotica
  • "A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors", 2022, Frontiers in Pharmacology

Frequent coauthors of Raunio include:

  • Risto O. Juvonen
  • Olli T. Pentikäinen
  • Juhani Huuskonen
  • Elmeri M. Jokinen
  • Olli Kärkkäinen

The scientist has published several articles in recognized venues, with multiple works appearing in:

  • Xenobiotica
  • International Journal of Molecular Sciences
  • ACS Omega
  • Chemical Biology & Drug Design
  • Frontiers in Pharmacology

Best Publications

  • The metabolism of coumarins : In; Coumarins: Biology, Applications and mode of action.

    Olavi Pelkonen;Hannu Raunio;Arja Rautio;Markku Pasanen

  • Inhibition and induction of human cytochrome P450 enzymes: current status.

    Olavi Pelkonen;Miia Turpeinen;Miia Turpeinen;Miia Turpeinen;Jukka Hakkola;Paavo Honkakoski

  • Prodrugs—from Serendipity to Rational Design

    Kristiina M. Huttunen;Hannu Raunio;Jarkko Rautio

  • Inhibition and induction of human cytochrome P450 (CYP) enzymes.

    Olavi Pelkonen;Jukka Mäenpää;Päivi Taavitsainen;Arja Rautio

  • CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.

    Fumihiro Sata;Andrea Sapone;Guillermo Elizondo;Penny Stocker

  • Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility-a review☆

    Hannu Raunio;Kirsti Husgafvel-Pursiainen;Sisko Anttila;Eino Hietanen

  • A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

    Fernandez-Salguero P;Hoffman Sm;Cholerton S;Mohrenweiser H

  • Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung.

    Janne Hukkanen;Olavi Pelkonen;Jukka Hakkola;Hannu Raunio

  • CYP2A6: a human coumarin 7-hydroxylase.

    Olavi Pelkonen;Arja Rautio;Hannu Raunio;Markku Pasanen

  • Xenobiotic-Metabolizing Cytochrome P450 Enzymes in the Human Feto-Placental Unit: Role in Intrauterine Toxicity

    Jukka Hakkola;Olavi Pelkonen;Markku Pasanen;Hannu Raunio

  • Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population.

    Mikael Oscarson;Roman A McLellan;Harriet Gullstén;Qun-Ying Yue

  • Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells.

    Jukka Hakkola;Markku Pasanen;Olavi Pelkonen;Janne Hukkanen

  • Expression of xenobiotic-metabolizing cytochrome P450 Forms in human full-term placenta

    Jukka Hakkola;Markku Pasanen;Janne Hukkanen;Olavi Pelkonen

  • Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism.

    Mikael Oscarson;Roman A. McLellan;Harriet Gullstén;José A.G. Agúndez

  • Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

    Jukka Hakkola;Markku Pasanen;Raija Purkunen;Seppo Saarikoski

  • Polymorphisms of CYP2A6 and its practical consequences.

    Hannu Raunio;Arja Rautio;Harriet Gullstén;Olavi Pelkonen

  • Characterization of the human dihydropyrimidine dehydrogenase gene.

    Xiaoxiong Wei;Guillermo Elizondo;Andrea Sapone;Howard L. McLeod

  • Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase

    Mikael Oscarson;Harriet Gullstén;Arja Rautio;Maria Luisa Bernal

  • Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy

    Jukka Hakkola;Hannu Raunio;Raija Purkunen;Olavi Pelkonen

  • Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line.

    Janne Hukkanen;Arja Lassila;Katja Päivärinta;Susanna Valanne

Frequent Co-Authors

Olavi Pelkonen
Olavi Pelkonen University of Oulu
Paavo Honkakoski
Paavo Honkakoski University of Eastern Finland
Ylermi Soini
Ylermi Soini University of Eastern Finland
José A. G. Agúndez
José A. G. Agúndez Instituto de Salud Carlos III
Seppo Auriola
Seppo Auriola University of Eastern Finland
Harry V. Gelboin
Harry V. Gelboin National Institutes of Health
Alan R. Boobis
Alan R. Boobis Imperial College London
Pedro M. Fernandez-Salguero
Pedro M. Fernandez-Salguero University of Extremadura
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Magnus Ingelman-Sundberg
Magnus Ingelman-Sundberg Karolinska Institute

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