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Biology and Biochemistry

D-Index
61
Citations
10552
World Ranking
11574
National Ranking
884

Overview

David F.V. Lewis was affiliated with the University of Surrey in the United Kingdom. Their research primarily focused on medicine, with a significant emphasis on obstetrics and gynecology. Their scholarly work covered several subfields including radiation, pediatrics, perinatology and child health, immunology, and pulmonary and respiratory medicine.

The scientist contributed to research topics spanning pregnancy and preeclampsia studies, reproductive system and pregnancy, birth, development and health, radiation detection and scintillator technologies, gestational diabetes research and management, as well as advanced radiotherapy techniques and radiation therapy and dosimetry.

The publication record of David F.V. Lewis included papers in various academic venues. The frequently appearing publication venues were:

  • Placenta
  • Medical Physics
  • Frontiers in Endocrinology
  • Journal of Reproductive Immunology
  • Pathophysiology

Their recent papers included the following:

  • "Report of AAPM Task Group 235 Radiochromic Film Dosimetry: An Update to TG-55" (2020), Medical Physics
  • "Upregulation of METTL3 expression and m6A RNA methylation in placental trophoblasts in preeclampsia" (2020), Placenta
  • "Downregulation of miR-126-3p expression contributes to increased inflammatory response in placental trophoblasts in preeclampsia" (2021), Journal of Reproductive Immunology
  • "Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia" (2020), American Journal of Obstetrics and Gynecology
  • "Preeclampsia Status Controls Interleukin-6 and Soluble IL-6 Receptor Release from Neutrophils and Endothelial Cells: Relevance to Increased Inflammatory Responses" (2021), Pathophysiology

Throughout their career, David F.V. Lewis collaborated frequently with several co-authors, including:

  • Yuping Wang
  • Yang Gu
  • John A. Morgan
  • Danielle B. Cooper
  • Charles E. McCathran

Best Publications

  • Interaction of a series of nitriles with the alcohol-inducible isoform of P450: Computer analysis of structure—activity relationships

    D. F. V. Lewis;C. Ioannides;D. V. Parke

  • 57 varieties: the human cytochromes P450

    David F V Lewis

  • Cytochromes P450 in the Bioactivation of Chemicals

    Costas Ioannides;David F V Lewis

  • On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human p450 substrate specificity and metabolism.

    David F.V. Lewis

  • Compound lipophilicity for substrate binding to human P450s in drug metabolism

    David F.V. Lewis;Miriam N. Jacobs;Maurice Dickins

  • Human cytochromes P450 associated with the phase 1 metabolism of drugs and other xenobiotics: a compilation of substrates and inhibitors of the CYP1, CYP2 and CYP3 families.

    David F V Lewis

  • Molecular dimensions of the substrate binding site of cytochrome P-448.

    David F.V. Lewis;Costas Ioannides;Dennis V. Parke

  • CYTOCHROMES P450 AND SPECIES DIFFERENCES IN XENOBIOTIC METABOLISM AND ACTIVATION OF CARCINOGEN

    David F. V. Lewis;Costas Ioannides;Dennis V. Parke

  • Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: comparison with dihydrocoumarin and other coumarin metabolites.

    Brian G. Lake;Tim J.B. Gray;John G. Evans;David F.V. Lewis

  • The CYP2 family: models, mutants and interactions

    David F. V. Lewis

  • STRUCTURAL DETERMINANTS OF CYTOCHROME P450 SUBSTRATE SPECIFICITY, BINDING AFFINITY AND CATALYTIC RATE

    D.F.V. Lewis;P.J. Eddershaw;M. Dickins;M.H. Tarbit

  • THE 1990 PHARMACEUTICAL-MANUFACTURERS-ASSOCIATION-OF-CANADA KEYNOTE LECTURE - THE ROLE OF THE CYTOCHROMES-P450 IN THE DETOXICATION AND ACTIVATION OF DRUGS AND OTHER CHEMICALS

    Dennis V. Parke;Costas Ioannides;David F. V. Lewis

  • Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102: structural studies on specific CYP2D6 substrate metabolism.

    D. F. V. Lewis;P. J. Eddershaw;P. S. Goldfarb;M. H. Tarbit

  • Steroid hormone receptors and dietary ligands: a selected review.

    Miriam N. Jacobs;David F. V. Lewis

  • Molecular modelling of CYP3A4 from an alignment with CYP102: identification of key interactions between putative active site residues and CYP3A-specific chemicals.

    D. F. V. Lewis;P. J. Eddershaw;P. S. Goldfarb;M. H. Tarbit

  • Structure–activity relationship for human cytochrome P450 substrates and inhibitors

    David F V Lewis;Sandeep Modi;Maurice Dickins

  • Interactions between redox partners in various cytochrome P450 systems: functional and structural aspects.

    David F.V. Lewis;Peter Hlavica

  • Substrate SARs in human P450s.

    David F V Lewis;Maurice Dickins

  • Allosteric phenomena in cytochrome P450-catalyzed monooxygenations

    Peter Hlavica;David F. V. Lewis

  • Guide to Cytochromes P450: Structure and Function, Second Edition

    David F.V. Lewis

Frequent Co-Authors

Costas Ioannides
Costas Ioannides University of Surrey
Brian G. Lake
Brian G. Lake University of Surrey
Olavi Pelkonen
Olavi Pelkonen University of Oulu
Magnus Ingelman-Sundberg
Magnus Ingelman-Sundberg Karolinska Institute
José V. Castell
José V. Castell University of Valencia
Dong-Qing Wei
Dong-Qing Wei Shanghai Jiao Tong University
André Guillouzo
André Guillouzo University of Rennes
Alan R. Boobis
Alan R. Boobis Imperial College London
F. Peter Guengerich
F. Peter Guengerich Vanderbilt University
Tsutomu Shimada
Tsutomu Shimada Osaka Metropolitan University

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