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Chemistry

D-Index
71
Citations
15661
World Ranking
5657
National Ranking
1746

Biology and Biochemistry

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70
Citations
15695
World Ranking
7090
National Ranking
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Overview

James R. Halpert is affiliated with the University of Connecticut in the United States. Their work spans multiple areas within pharmacology, toxicology, and pharmaceutics, with additional contributions related to medicine.

The scientist's recent publications cover a range of topics primarily focused on pharmacogenetics and drug metabolism. Some notable papers include:

  • Strategies in herbivory by mammals revisited: The role of liver metabolism in a juniper specialist (Neotoma stephensi) and a generalist (Neotoma albigula), 2020, Molecular Ecology
  • Four Decades of Cytochrome P450 2B Research: From Protein Adducts to Protein Structures and Beyond, 2022, Drug Metabolism and Disposition
  • Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, 2022, Advances in pharmacology
  • The Evolution of Drug Metabolism and Disposition: A Perspective From the Editors, 2022, Drug Metabolism and Disposition
  • So many roads traveled: A career in science and administration, 2020, Journal of Biological Chemistry

These publications often explore cytochrome P450 enzymes, their diversity, structure, and role in drug metabolism, alongside ecological aspects of animal herbivory and metabolism.

Frequent coauthors who have collaborated with James R. Halpert include:

  • Michele M. Skopec
  • P. Ross Wilderman
  • M. Denise Dearing
  • Jeffrey Stevens
  • Teri J. Orr

The researcher has published multiple articles in venues such as:

  • Drug Metabolism and Disposition
  • Journal of Biological Chemistry
  • Molecular Ecology
  • Advances in pharmacology
  • The FASEB Journal

James R. Halpert's main fields of study include pharmacology, toxicology and pharmaceutics, and medicine. Subfields of their research incorporate pharmacology, molecular biology, ecology, pediatrics, perinatology and child health, along with computational theory and mathematics.

The core topics addressed in their work are:

  • Pharmacogenetics and Drug Metabolism
  • Pharmacological Effects and Toxicity Studies
  • Computational Drug Discovery Methods
  • Analytical Chemistry and Chromatography
  • Animal Ecology and Behavior Studies
  • Wildlife Ecology and Conservation
  • Metabolomics and Mass Spectrometry Studies

Best Publications

  • Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.

    M D Burke;S Thompson;C R Elcombe;J Halpert

  • The genetic determinants of the CYP3A5 polymorphism

    Elisabeth Hustert;Michael Haberl;Oliver Burk;Renzo Wolbold

  • An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

    Emily E. Scott;You Ai He;Michael R. Wester;Mark A. White

  • Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding.

    Emily E. Scott;Mark A. White;You Ai He;Eric F. Johnson

  • Identification and functional characterization of eight CYP3A4 protein variants.

    Regina Eiselt;Tammy L. Domanski;Arne Zibat;Romy Mueller

  • Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics.

    Greg R. Harlow;James R. Halpert

  • Selective inhibitors of cytochromes P450.

    J R Halpert;F P Guengerich;J R Bend;M A Correia

  • cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450.

    Tammy L. Domanski;Csaba Finta;James R. Halpert;Peter G. Zaphiropoulos

  • TOXICOLOGY OF THIONO-SULFUR COMPOUNDS

    Robert A. Neal;James Halpert

  • Amino acid sequence of a presynaptic neurotoxin from the venom of Notechis scutatus scutatus (Australian tiger snake).

    J Halpert;D Eaker

  • Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation

    Kishore K. Khan;You Qun He;Tammy L. Domanski;James R. Halpert

  • Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

    Yonghong Zhao;Mark A. White;B.K. Muralidhara;Ling Sun

  • Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity

    Greg R. Harlow;James R. Halpert

  • Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis.

    T L Domanski;J R Halpert

  • Molecular modeling of cytochrome P450 3A4

    Grazyna D. Szklarz;James R. Halpert

  • Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity.

    Tammy L. Domanski;You-Ai He;Kishore K. Khan;Fabienne Roussel

  • Analysis of Four Residues within Substrate Recognition Site 4 of Human Cytochrome P450 3A4: Role in Steroid Hydroxylase Activity and α-Naphthoflavone Stimulation

    Tammy L. Domanski;Juping Liu;Greg R. Harlow;James R. Halpert

  • A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function.

    Emily E. Scott;Margit Spatzenegger;James R. Halpert

  • Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe.

    Huifen Wang;Ryan Dick;Hequn Yin;Estefania Licad-Coles

  • Structural Basis of Selective Cytochrome P450 Inhibition

    James R. Halpert

Frequent Co-Authors

Hong Liu
Hong Liu Shandong University
Eric F. Johnson
Eric F. Johnson AbbVie (United States)
Richard M. Philpot
Richard M. Philpot National Institutes of Health
C. David Stout
C. David Stout Scripps Research Institute
Paul F. Hollenberg
Paul F. Hollenberg University of Michigan–Ann Arbor
Weihua Li
Weihua Li East China University of Science and Technology
David J. Waxman
David J. Waxman Boston University
Rune Toftgård
Rune Toftgård Karolinska Institute
John R. Bend
John R. Bend University of Western Ontario
Dennis R. Koop
Dennis R. Koop Oregon Health & Science University

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