World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
95
Citations
36328
World Ranking
9996
National Ranking
5145

Research.com Recognitions

  • 1998 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Kenneth E. Thummel is affiliated with the University of Washington in the United States. Their research primarily focuses on medicine, with significant contributions in pharmacology, oncology, physiology, pathology and forensic medicine, and molecular biology.

The scientist has published extensively on topics including pharmacogenetics and drug metabolism, vitamin D research studies, drug transport and resistance mechanisms, pharmacological effects and toxicity studies, synthesis and pharmacology of alkaloids, traditional and medicinal uses of Annonaceae, as well as chemical synthesis and alkaloids.

Notable recent papers include:

  • Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease, 2020, American Journal of Respiratory and Critical Care Medicine
  • Clinical Pharmacokinetic Assessment of Kratom (Mitragyna speciosa), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants, 2022, Pharmaceutics
  • Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants, 2023, Clinical Pharmacology & Therapeutics
  • Effects of Pregnancy on the Pharmacokinetics of Metformin, 2020, Drug Metabolism and Disposition
  • Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail, 2020, Clinical Pharmacology & Therapeutics

Frequent coauthors in their work include Mary F. Paine, Allan E. Rettie, Edward J. Kelly, Christopher M. Arian, and Nadja B. Cech.

Publications by Kenneth E. Thummel often appear in these venues:

  • Journal of Pharmacology and Experimental Therapeutics
  • Drug Metabolism and Disposition
  • Clinical and Translational Science
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Clinical Pharmacology & Therapeutics

In 1998, Kenneth E. Thummel was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.

    Peter Kuehl;Jiong Zhang;Yvonne Lin;Jatinder Lamba

  • Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.

    Mark J. Rieder;Alexander P. Reiner;Brian F. Gage;Deborah A. Nickerson

  • Genetic contribution to variable human CYP3A-mediated metabolism

    Jatinder K Lamba;Yvonne S Lin;Erin G Schuetz;Kenneth E Thummel

  • IN VITRO AND IN VIVO DRUG INTERACTIONS INVOLVING HUMAN CYP3A

    K. E. Thummel;G. R. Wilkinson

  • Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism

    Mary F. Paine;Mehraneh Khalighi;Jeannine M. Fisher;Danny D. Shen

  • Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism

    Kenneth E. Thummel;Kenneth E. Thummel;Diarmuid O'Shea;Diarmuid O'Shea;Mary F. Paine;Mary F. Paine;Danny D. Shen;Danny D. Shen

  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing

    K.A. Birdwell;B. Decker;J.M. Barbarino;J.F. Peterson

  • First-pass metabolism of midazolam by the human intestine

    Mary F. Paine;Danny D. Shen;Kent L. Kunze;James D. Perkins

  • HUMAN LIVER CARBAMAZEPINE METABOLISM. ROLE OF CYP3A4 AND CYP2C8 IN 10, 11-EPOXIDE FORMATION

    Bradley M. Kerr;Kenneth E. Thummel;Colleen J. Wurden;Susan M. Klein

  • Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism.

    Yvonne S. Lin;Amy L. S. Dowling;Sean D. Quigley;Federico M. Farin

  • Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents : Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins

    Phyllissa Schmiedlin-Ren;David J. Edwards;Michael E. Fitzsimmons;Kan He

  • Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test.

    K S Lown;J C Kolars;K E Thummel;J L Barnett

  • Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation

    Changcheng Zhou;Michelle M. Tabb;Edward L. Nelson;Felix Grün

  • Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

    K E Thummel;D D Shen;T D Podoll;K L Kunze

  • Expression of Enzymatically Active CYP3A4 by Caco-2 Cells Grown on Extracellular Matrix-Coated Permeable Supports in the Presence of 1α,25-Dihydroxyvitamin D3

    Phyllissa Schmiedlin-Ren;Kenneth E. Thummel;Jeannine M. Fisher;Mary F. Paine

  • New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process

    Shiew Mei Huang;John M. Strong;Lei Zhang;Kellie S. Reynolds

  • Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4.

    Kenneth E. Thummel;Caroline A. Lee;Kent L. Kunze;Sidney D. Nelson

  • Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction

    Shen Dd;Kunze Kl;Thummel Ke

  • Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane

    Evan D. Kharasch;Kenneth E. Thummel

  • Common allelic variants of cytochrome P4503A4 and their prevalence in different populations.

    Jatinder K. Lamba;Yvonne S. Lin;Kenneth Thummel;Ann Daly

Frequent Co-Authors

Evan D. Kharasch
Evan D. Kharasch Duke University
Erin G. Schuetz
Erin G. Schuetz St. Jude Children's Research Hospital
Kent L. Kunze
Kent L. Kunze University of Washington
Paul B. Watkins
Paul B. Watkins University of North Carolina at Chapel Hill
Nina Isoherranen
Nina Isoherranen University of Washington
Allan E. Rettie
Allan E. Rettie University of Washington
Sidney D. Nelson
Sidney D. Nelson University of Washington
Jashvant D. Unadkat
Jashvant D. Unadkat University of Washington
Wylie Burke
Wylie Burke University of Washington
Melissa A. Austin
Melissa A. Austin University of Washington

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

If you’re interested in careers related to medicine but want flexible learning options, several online degree pathways can help you enter or advance in the healthcare field. For students seeking a nursing career without the standard entry exams, some nursing school that does not require teas test can be a great alternative for pursuing an RN license.

If you’re focused on leadership or administrative roles in healthcare, consider earning a health care administration degree online. These programs are designed for busy adults and can lead to careers managing hospitals, clinics, or health systems.

Already a registered nurse? Transitioning to advanced practice roles such as Family Nurse Practitioner is accessible with adn to fnp bridge programs, providing a flexible way to further your qualifications.

For those interested in preventative medicine, wellness, and dietetics, an online bs in nutrition program offers the opportunity to start a career in nutrition counseling or health education. These diverse online degrees broaden your career options within healthcare beyond traditional medical school.

Best Scientists Citing Kenneth E. Thummel

Trending Scientists

Recently Published Articles