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D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
17249
World Ranking
4185
National Ranking
2047

Overview

Jashvant D. Unadkat is affiliated with the University of Washington in the United States. Their research primarily falls within the field of Medicine, with a particular focus on subfields including Oncology, Pharmacology, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health, and Surgery.

The scientist's work covers a range of topics that intersect drug metabolism and clinical pharmacology. Key areas of research include:

  • Drug Transport and Resistance Mechanisms
  • Cannabis and Cannabinoid Research
  • Pharmacogenetics and Drug Metabolism
  • Pharmacological Effects and Toxicity Studies
  • Pregnancy and Medication Impact
  • Pregnancy and Preeclampsia Studies
  • Liver Disease Diagnosis and Treatment

Unadkat has contributed to numerous publications, prominently appearing in the following journals based on volume of work:

  • Drug Metabolism and Disposition
  • Clinical Pharmacology & Therapeutics
  • Drug Metabolism and Pharmacokinetics
  • The FASEB Journal
  • Journal of Pharmacology and Experimental Therapeutics

Their recent papers demonstrate a focus on clinical and pharmacokinetic applications, frequently addressing pharmacokinetic drug interactions, cannabinoid research, and placental transporter regulation. Notable publications include:

  • Applications, Challenges, and Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic Perspective (2022) in Pharmaceutical Research
  • Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 (2020) in Drug Metabolism and Disposition
  • Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial (2023) in JAMA Network Open
  • Gestational Age-Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics (2020) in Drug Metabolism and Disposition
  • Comprehensive Predictions of Cytochrome P450 (P450)-Mediated In Vivo Cannabinoid-Drug Interactions Based on Reversible and Time-Dependent P450 Inhibition in Human Liver Microsomes (2022) in Drug Metabolism and Disposition

The scientist collaborates frequently with several researchers, including:

  • Qingcheng Mao
  • Aditya R. Kumar
  • Mary F. Paine
  • Flavia Storelli
  • Mengyue Yin

Best Publications

  • Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update

    Qingcheng Mao;Jashvant D. Unadkat

  • Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography.

    Lucy Sasongko;Jeanne M. Link;Mark Muzi;David A. Mankoff

  • Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities.

    Dean Hickman;Ji Ping Wang;Yi Wang;Jashvant D. Unadkat

  • HIV Protease Inhibitors Are Inhibitors but Not Substrates of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

    Anshul Gupta;Yi Zhang;Jashvant D. Unadkat;Qingcheng Mao

  • Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine

    Marek Drozdzik;Christian Gröer;Jette Penski;Joanna Lapczuk

  • Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study.

    MF Hebert;TR Easterling;B Kirby;DB Carr

  • The role of transporters in drug interactions

    Christopher J. Endres;Peng Hsiao;Francisco S. Chung;Jashvant D. Unadkat

  • Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice.

    MF Hebert;X Ma;SB Naraharisetti;KM Krudys

  • Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex

    Bhagwat Prasad;Raymond Evers;Anshul Gupta;Cornelis E. C. A. Hop

  • Drug interactions at the blood-brain barrier: fact or fantasy?

    Sara Eyal;Peng Hsiao;Jashvant D. Unadkat

  • Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance

    Maciej J Zamek-Gliszczynski;Mitchell E Taub;Paresh P Chothe;Xiaoyan Chu

  • P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages

    Anita A. Mathias;Jane Hitti;Jashvant D. Unadkat

  • Regulation of BCRP/ABCG2 expression by progesterone and 17β-estradiol in human placental BeWo cells

    Honggang Wang;Lin Zhou;Anshul Gupta;R. Robert Vethanayagam

  • Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions.

    Vaishali Dixit;Niresh Hariparsad;Fang Li;Pankaj Desai

  • Activity of P-Glycoprotein, a β-Amyloid Transporter at the Blood–Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease

    Anand K. Deo;Soo Borson;Jeanne M. Link;Karen Domino

  • Interspecies Variability in Expression of Hepatobiliary Transporters across Human, Dog, Monkey, and Rat as Determined by Quantitative Proteomics

    Li Wang;Bhagwat Prasad;Laurent Salphati;Xiaoyan Chu

  • Expression of arylamine N-acetyltransferase in human intestine

    D Hickman;J Pope;S D Patil;G Fakis

  • Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs

    Yurong Lai;Chung Ming Tse;Jashvant D. Unadkat

  • The extent of metabolism of inhaled anesthetics in humans.

    Randall L. Carpenter;Edmond I. Eger;Brynte H. Johnson;Jashvant D. Unadkat

  • In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta

    Rajgopal Govindarajan;Aimee H. Bakken;Kelly L. Hudkins;Yurong Lai;Yurong Lai

Frequent Co-Authors

Arnold L. Smith
Arnold L. Smith Center for Infectious Disease Research
Kenneth E. Thummel
Kenneth E. Thummel University of Washington
Ann C. Collier
Ann C. Collier University of Washington
David A. Mankoff
David A. Mankoff University of Pennsylvania
Amin Rostami-Hodjegan
Amin Rostami-Hodjegan University of Manchester
Dale Whittington
Dale Whittington University of North Carolina at Chapel Hill
Evan D. Kharasch
Evan D. Kharasch Duke University
Allan E. Rettie
Allan E. Rettie University of Washington
Nina Isoherranen
Nina Isoherranen University of Washington
Adrian S. Ray
Adrian S. Ray Yale University

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