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Biology and Biochemistry

D-Index
54
Citations
10389
World Ranking
15645
National Ranking
6526

Overview

Lauren M. Aleksunes is affiliated with Rutgers, The State University of New Jersey, in the United States. Their research is concentrated primarily within the field of medicine, including specialized focus areas such as health, toxicology and mutagenesis, molecular biology, pediatrics, perinatology and child health, oncology, and pathology and forensic medicine.

Their scholarly output includes a notable presence in several publication venues. Frequent publication outlets for Aleksunes's work include the Journal of the American Society of Nephrology, Placenta, the Journal of Biochemical and Molecular Toxicology, the Journal of Clinical and Translational Science, and Drug Metabolism and Disposition.

Research topics addressed by Lauren M. Aleksunes cover diverse areas related to drug discovery, toxicity, and developmental health. Key topics explored in their publications include:

  • Chemotherapy-induced organ toxicity mitigation
  • Computational drug discovery methods
  • Drug transport and resistance mechanisms
  • Pregnancy and preeclampsia studies
  • Heavy metal exposure and toxicity
  • Birth, development, and health
  • Pharmacological effects and toxicity studies

Their recent peer-reviewed publications demonstrate a focus on both experimental and computational methods within toxicology and pharmacology. Selected recent papers include:

  • Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling (2020), published in Drug Discovery Today
  • Membrane transporters in drug development and as determinants of precision medicine (2024), published in Nature Reviews Drug Discovery
  • Extravillous trophoblast migration and invasion: Impact of environmental chemicals and pharmaceuticals (2021), published in Reproductive Toxicology
  • Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- and deep-learning approaches (2020), published in Laboratory Investigation
  • Revealing Adverse Outcome Pathways from Public High-Throughput Screening Data to Evaluate New Toxicants by a Knowledge-Based Deep Neural Network Approach (2021), published in Environmental Science & Technology

Aleksunes collaborates frequently with several coauthors, including Emily S. Barrett, Melanie S. Joy, Wen Xia, Brian Buckley, and Cathleen Doherty, reflecting a network of interdisciplinary scientific partnerships.

Best Publications

  • Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

    Curtis D. Klaassen;Lauren M. Aleksunes

  • Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease

    Lauren M. Aleksunes;José E. Manautou

  • Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway

    Jonathan M. Maher;Matthew Z. Dieter;Lauren M. Aleksunes;Angela L. Slitt;Angela L. Slitt

  • Introducing the "TCDD-inducible AhR-Nrf2 gene battery".

    Ronnie L. Yeager;Scott A. Reisman;Lauren M. Aleksunes;Curtis D. Klaassen

  • Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice

    Lauren M. Aleksunes;Curtis D. Klaassen

  • NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet

    Yuji Tanaka;Lauren M. Aleksunes;Ronnie L. Yeager;Maxwell A. Gyamfi

  • Antibacterial Spectrum of a Novel Des-Fluoro(6) Quinolone, BMS-284756

    Joan C. Fung-Tomc;Beatrice Minassian;Benjamin Kolek;Elizabeth Huczko

  • Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes.

    Scott A. Reisman;Lauren M. Aleksunes;Curtis D. Klaassen

  • Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity.

    Lauren M. Aleksunes;Michael J. Goedken;Cheryl E. Rockwell;Juergen Thomale

  • Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

    Lauren M. Aleksunes;Angela L. Slitt;Jonathan M. Maher;Lisa M. Augustine

  • Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.

    Kim L.R. Brouwer;Lauren M. Aleksunes;Barbara Brandys;George P. Giacoia

  • Placental Drug Transport-on-a-Chip: A Microengineered In Vitro Model of Transporter-Mediated Drug Efflux in the Human Placental Barrier

    Cassidy Blundell;Yoon-Suk Yi;Lin Ma;Emily R. Tess

  • ANIT-Induced Intrahepatic Cholestasis Alters Hepatobiliary Transporter Expression via Nrf2-Dependent and Independent Signaling

    Yuji Tanaka;Lauren M. Aleksunes;Yue Julia Cui;Curtis D. Klaassen

  • Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride.

    Lauren M. Aleksunes;Angela M. Slitt;Nathan J. Cherrington;Michael S. Thibodeau

  • Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity

    Qiuqiong Cheng;Lauren M. Aleksunes;José E. Manautou;Nathan J. Cherrington

  • Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice

    Lauren M. Aleksunes;Scott A. Reisman;Ronnie L. Yeager;Michael J. Goedken

  • Xenobiotic transporters and kidney injury.

    Blessy George;Dahea You;Melanie S. Joy;Lauren M. Aleksunes

  • Nrf2- and PPARα-Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid

    Jonathan M. Maher;Lauren M. Aleksunes;Lauren M. Aleksunes;Matthew Z. Dieter;Yuji Tanaka

  • Renal and Hepatic Transporter Expression in Type 2 Diabetic Rats

    Michael T Nowicki;Lauren M Aleksunes;Sharmilee P Sawant;Ankur V Dnyanmote

  • Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury.

    Lauren M. Aleksunes;George L. Scheffer;Amy B. Jakowski;Ingrid M. Pruimboom-Brees

Frequent Co-Authors

Curtis D. Klaassen
Curtis D. Klaassen University of Kansas
George L. Scheffer
George L. Scheffer VU University Medical Center
Debra L. Laskin
Debra L. Laskin Rutgers, The State University of New Jersey
Jeffrey D. Laskin
Jeffrey D. Laskin Rutgers, The State University of New Jersey
Hao Zhu
Hao Zhu Rutgers, The State University of New Jersey
Jefferson Y. Chan
Jefferson Y. Chan University of Illinois at Urbana-Champaign
Thomas W. Kensler
Thomas W. Kensler Johns Hopkins University
Scott W. Burchiel
Scott W. Burchiel University of New Mexico
Laurie G. Hudson
Laurie G. Hudson University of New Mexico
Ulrich M. Zanger
Ulrich M. Zanger Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology

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