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Medicine

D-Index
88
Citations
27583
World Ranking
13189
National Ranking
505

Overview

George L. Scheffer was affiliated with the VU University Medical Center in the Netherlands. Their work spanned multiple interconnected fields within medicine, primarily focusing on oncology, radiology, nuclear medicine and imaging, and immunology.

Their research contributions consisted of studies in areas such as CAR-T cell therapy, monoclonal and polyclonal antibodies, and immune cell function and interaction.

  • CAR-T cell therapy research
  • Monoclonal and Polyclonal Antibodies Research
  • Immune Cell Function and Interaction

Among their recent published papers were:

  • "A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell-Mediated Antitumor Responses in Human B-cell Malignancies" (2020), published in Cancer Immunology Research
  • "PD-L1 directed bispecific Vδ2-T cell engager combines lysis of PD-L1 expressing tumor cells with PD-1 immune checkpoint inhibition and modulation of the tumor immune microenvironment" (2025), published in Journal for ImmunoTherapy of Cancer

Their frequent co-authors included:

  • Tanja D. de Gruijl
  • Hans van Vliet
  • Iris de Weerdt
  • Roeland Lameris
  • Jana Vree

George L. Scheffer's research appeared primarily in the following publication venues:

  • Cancer Immunology Research
  • Journal for ImmunoTherapy of Cancer

The overall body of work reflected interdisciplinary approaches engaging with immune mechanisms in cancer therapy, particularly emphasizing cellular immunotherapy and antibody-mediated modulation.

Best Publications

  • Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

    M Maliepaard;G L Scheffer;I F Faneyte;M A van Gastelen

  • Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

    M. Kool;M. De Haas;G. L. Scheffer;R. J. Scheper

  • Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.

    Coen C. Paulusma;Piter J. Bosma;Guido J. R. Zaman;Conny T. M. Bakker

  • The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

    Johan W. Jonker;Marije Buitelaar;Els Wagenaar;Martin A. van der Valk

  • The drug resistance-related protein LRP is the human major vault protein

    George L. Scheffer;Peter L.J. Wijngaard;Marcel J. Flens;Miguel A. Izquierdo

  • Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

    R.J. Scheper;H.J. Broxterman;G.L. Scheffer;P. Kaaijk

  • MRP3, an organic anion transporter able to transport anti-cancer drugs

    M. Kool;M. van der Linden;M. de Haas;G. L. Scheffer

  • Tissue distribution of the multidrug resistance protein.

    M. J. Flens;G. J. R. Zaman;P. Van Der Valk;M. A. Izquierdo

  • A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome.

    C. C. Paulusma;M. Kool;P. J. Bosma;G. L. Scheffer

  • Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

    J Wijnholds;C A Mol;L van Deemter;M de Haas

  • The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood☆☆☆

    Emmanuel Jacquemin;Olivier Bernard;Michelle Hadchouel;Danièle Cresteil

  • Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein

    Ruud Oerlemans;Niels E. Franke;Yehuda G. Assaraf;Jacqueline Cloos

  • Mrp4 confers resistance to topotecan and protects the brain from chemotherapy.

    Markos Leggas;Masashi Adachi;George L. Scheffer;Daxi Sun

  • Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

    Jan Wijnholds;Elizabeth C.M. de Lange;George L. Scheffer;Dirk-Jan van den Berg

  • Immunochemical Detection of the Multidrug Resistance-associated Protein MRP in Human Multidrug-resistant Tumor Cells by Monoclonal Antibodies

    Marcel J. Flens;Miguel A. Izquierdo;George L. Scheffer;Jan M. Fritz

  • Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material.

    Julio E. Diestra;George L. Scheffer;Isabel Català;Marc Maliepaard

  • Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway

    Jonathan M. Maher;Matthew Z. Dieter;Lauren M. Aleksunes;Angela L. Slitt;Angela L. Slitt

  • Tissue Distribution and Induction of Human Multidrug Resistant Protein 3

    George L Scheffer;Marcel Kool;Marcel de Haas;J Marleen L de Vree

  • Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia

    Alan F. List;Catherine S. Spier;Thomas M. Grogan;Cynthia Johnson

  • Drug resistance-associated marker LRP for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma

    M A Izquierdo;A G van der Zee;J B Vermorken;P van der Valk

Frequent Co-Authors

Rik J. Scheper
Rik J. Scheper Amsterdam University Medical Centers
Gerrit Jansen
Gerrit Jansen Amsterdam UMC
Tanja D. de Gruijl
Tanja D. de Gruijl Vrije Universiteit Amsterdam
Yehuda G. Assaraf
Yehuda G. Assaraf Technion – Israel Institute of Technology
Godefridus J. Peters
Godefridus J. Peters Gdańsk Medical University
Willem F. Lems
Willem F. Lems Vrije Universiteit Amsterdam
Piet Borst
Piet Borst Antoni van Leeuwenhoek Hospital
Paul van der Valk
Paul van der Valk Vrije Universiteit Amsterdam
Lauren M. Aleksunes
Lauren M. Aleksunes Rutgers, The State University of New Jersey
Robert H. Shoemaker
Robert H. Shoemaker National Institutes of Health

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