What is he best known for?
The fields of study he is best known for:
George L. Scheffer mainly investigates Pathology, Molecular biology, Multidrug resistance-associated protein 2, Multiple drug resistance and P-glycoprotein.
His study in the fields of Immunohistochemistry and Epithelium under the domain of Pathology overlaps with other disciplines such as Progressive familial intrahepatic cholestasis.
While the research belongs to areas of Immunohistochemistry, George L. Scheffer spends his time largely on the problem of Monoclonal antibody, intersecting his research to questions surrounding ATP-binding cassette transporter and Abcg2.
His work focuses on many connections between Molecular biology and other disciplines, such as Cell culture, that overlap with his field of interest in In vitro, Multidrug Resistance-Associated Proteins and Cell growth.
His Multidrug resistance-associated protein 2 study contributes to a more complete understanding of Biochemistry.
George L. Scheffer interconnects Gene and Major vault protein in the investigation of issues within Multiple drug resistance.
His most cited work include:
- Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. (982 citations)
- Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (819 citations)
- Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. (765 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Abcg2, Cancer research, Multiple drug resistance, Molecular biology and P-glycoprotein.
The Abcg2 study combines topics in areas such as Stem cell, Mitoxantrone and Pharmacology.
His Cancer research research also works with subjects such as
- Immunology that connect with fields like Cellular differentiation,
- Multidrug Resistance-Associated Proteins and related Transport protein.
George L. Scheffer works mostly in the field of Multiple drug resistance, limiting it down to topics relating to Multidrug resistance-associated protein 2 and, in certain cases, Endocrinology and Internal medicine.
The study incorporates disciplines such as Cell culture, Gene expression, Gene and Monoclonal antibody in addition to Molecular biology.
His P-glycoprotein study combines topics in areas such as Pathology, Blood–brain barrier and Major vault protein.
He most often published in these fields:
- Abcg2 (25.00%)
- Cancer research (23.86%)
- Multiple drug resistance (23.30%)
What were the highlights of his more recent work (between 2010-2021)?
- Internal medicine (18.75%)
- Cancer research (23.86%)
- Pharmacology (15.91%)
In recent papers he was focusing on the following fields of study:
Internal medicine, Cancer research, Pharmacology, Abcg2 and Endocrinology are his primary areas of study.
He has researched Cancer research in several fields, including T cell, Immunology, Breast cancer, Bone metastasis and Surgical oncology.
His study in Pharmacology is interdisciplinary in nature, drawing from both Proteasome inhibitor, Cell culture, Proteasome and Bortezomib.
His Abcg2 research is multidisciplinary, relying on both Lung cancer and Cell biology.
In his research on the topic of Endocrinology, Testosterone is strongly related with ATP-binding cassette transporter.
His Multidrug resistance-associated protein 2 research is multidisciplinary, incorporating perspectives in Molecular biology, Multiple drug resistance, Monoclonal antibody and Multidrug Resistance Proteins.
Between 2010 and 2021, his most popular works were:
- Variations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver Disease (89 citations)
- Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis. (88 citations)
- Sensing of latent EBV infection through exosomal transfer of 5′pppRNA (83 citations)
In his most recent research, the most cited papers focused on:
George L. Scheffer focuses on Abcg2, Cell biology, Gene knockdown, P-glycoprotein and Biochemistry.
George L. Scheffer combines subjects such as Adenosine, Glial fibrillary acidic protein, Antibody, Monoclonal antibody and Flow cytometry with his study of Abcg2.
His studies in Cell biology integrate themes in fields like Caenorhabditis elegans, ABCC5, Multidrug Resistance-Associated Proteins, Heme and RNA interference.
George L. Scheffer focuses mostly in the field of Gene knockdown, narrowing it down to matters related to Bone metastasis and, in some cases, Cancer research.
His P-glycoprotein research incorporates elements of Peripheral blood mononuclear cell, Pharmacology, Bortezomib and Proteasome.
His research on Biochemistry frequently links to adjacent areas such as Molecular biology.
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