His primary scientific interests are in Pharmacology, Biochemistry, Organic anion transporter 1, Efflux and Transporter. His Pharmacology research includes elements of Internal medicine, Kidney, Abcg2 and Multidrug resistance-associated protein 2. His Organic Anion Transport Protein 1 and Glucuronide study in the realm of Biochemistry connects with subjects such as Sitosterolemia.
The Organic anion transporter 1 study combines topics in areas such as Probenecid, Virus, Viral replication and Organic cation transport proteins. His work deals with themes such as P-glycoprotein, Blood–brain barrier and Intracellular, which intersect with Efflux. As part of one scientific family, Hiroyuki Kusuhara deals mainly with the area of Transporter, narrowing it down to issues related to the Drug, and often Biophysics and Cerebrospinal fluid.
Hiroyuki Kusuhara mostly deals with Pharmacology, Transporter, Pharmacokinetics, Internal medicine and Organic anion transporter 1. His research in Pharmacology intersects with topics in Efflux, Kidney, Abcg2 and In vivo. His studies deal with areas such as Cell biology and Choroid plexus as well as Transporter.
His work on Physiologically based pharmacokinetic modelling as part of general Pharmacokinetics research is frequently linked to Crossover study, bridging the gap between disciplines. Hiroyuki Kusuhara usually deals with Internal medicine and limits it to topics linked to Endocrinology and Knockout mouse. Organic anion transporter 1 is the subject of his research, which falls under Biochemistry.
His primary areas of investigation include Pharmacology, Drug, Pharmacokinetics, Transporter and In vivo. His work on Pitavastatin as part of general Pharmacology research is often related to Crossover study, thus linking different fields of science. His Pharmacokinetics research includes elements of Oral administration, Distribution and Multidrug resistance-associated protein 2.
The concepts of his Transporter study are interwoven with issues in Phenotype, Efflux, In vitro and Cell biology. His Efflux study integrates concerns from other disciplines, such as Abcg2, Ussing chamber, Peptide transporter 1, Molecular biology and Kidney. His In vivo study combines topics in areas such as Biomarker, Local field potential and Premovement neuronal activity.
Hiroyuki Kusuhara focuses on Pharmacology, Transporter, Pharmacokinetics, Endogeny and In vivo. His Pharmacology research integrates issues from Organic anion transporter 1, Organic anion-transporting polypeptide, Biomarker and Rifampicin. His Organic anion transporter 1 research incorporates elements of Cimetidine and Renal function.
He combines subjects such as Inflammation, Lipopolysaccharide, Drug and Cell biology with his study of Transporter. His Pharmacokinetics study deals with Distribution intersecting with Excretion, Drug development, New chemical entity and Urine. His In vivo research is multidisciplinary, incorporating elements of Messenger RNA, Gene knockin, Sultopride and Ligand.
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Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.
Yohei Nishizato;Ichiro Ieiri;Hiroshi Suzuki;Miyuki Kimura.
Clinical Pharmacology & Therapeutics (2003)
Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain
Hiroyuki Kusuhara;Takashi Sekine;Naoko Utsunomiya-Tate;Minoru Tsuda.
Journal of Biological Chemistry (1999)
Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.
Seok Ho Cha;Takashi Sekine;Hiroyuki Kusuhara;Hiroyuki Kusuhara;Erkang Yu.
Journal of Biological Chemistry (2000)
Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans
Takao Watanabe;Hiroyuki Kusuhara;Kazuya Maeda;Yoshihisa Shitara.
Journal of Pharmacology and Experimental Therapeutics (2009)
Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone
Hiroshi Kodaira;Hiroyuki Kusuhara;Junko Ushiki;Eiichi Fuse.
Journal of Pharmacology and Experimental Therapeutics (2010)
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir.
Tomoki Imaoka;Hiroyuki Kusuhara;Masashi Adachi;John D. Schuetz.
Molecular Pharmacology (2007)
Functional Characterization of Rat Brain-specific Organic Anion Transporter (Oatp14) at the Blood-Brain Barrier HIGH AFFINITY TRANSPORTER FOR THYROXINE
Daisuke Sugiyama;Hiroyuki Kusuhara;Hirokazu Taniguchi;Shumpei Ishikawa.
Journal of Biological Chemistry (2003)
Involvement of BCRP (ABCG2) in the Biliary Excretion of Pitavastatin
Masaru Hirano;Kazuya Maeda;Soichiro Matsushima;Yoshitane Nozaki.
Molecular Pharmacology (2005)
Active efflux across the blood-brain barrier: role of the solute carrier family.
Hiroyuki Kusuhara;Yuichi Sugiyama.
Neurorx (2005)
Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)
Koichi Watashi;Ann Sluder;Takuji Daito;Takuji Daito;Satoko Matsunaga.
Hepatology (2014)
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