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Hiroyuki Kusuhara

Hiroyuki Kusuhara

D-Index & Metrics

Medicine

D-Index
94
Citations
25563
World Ranking
10618
National Ranking
302

Overview

Hiroyuki Kusuhara is affiliated with the University of Tokyo in Japan and has a significant body of research in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their scholarly work spans multiple subfields including Molecular Biology, Oncology, Pharmacology, Pediatrics, Perinatology and Child Health, as well as Computational Theory and Mathematics.

The primary topics of Kusuhara's research include Drug Transport and Resistance Mechanisms, Pharmacogenetics and Drug Metabolism, Computational Drug Discovery Methods, Pharmacological Effects and Toxicity Studies, Amino Acid Enzymes and Metabolism, Machine Learning in Materials Science, and Metabolomics and Mass Spectrometry Studies.

Kusuhara's recent publications illustrate the scope and diversity of their research interests. The following papers reflect contributions to pharmaceutical sciences, pharmacokinetics, and biomedical engineering:

  • "Phase 0/microdosing approaches: time for mainstream application in drug development?", 2020, Nature Reviews Drug Discovery
  • "Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein-Mediated Drug-Drug Interactions in Healthy Volunteers", 2020, Clinical Pharmacology & Therapeutics
  • "Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes", 2021, ACS Biomaterials Science & Engineering
  • "A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)", 2024, Science Advances
  • "Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel", 2020, Drug Metabolism and Disposition

Kusuhara frequently publishes in several scientific venues, including:

  • Drug Metabolism and Disposition
  • Drug Metabolism and Pharmacokinetics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • arXiv (Cornell University)
  • Clinical Pharmacology & Therapeutics

Collaborations are an important aspect of Kusuhara's research environment. The most frequent coauthors include Tadahaya Mizuno, Kazuya Maeda, Yuichi Sugiyama, Katsuhisa Morita, and Shumpei Nemoto, highlighting an active research network across multiple projects.

Best Publications

  • Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.

    Yohei Nishizato;Ichiro Ieiri;Hiroshi Suzuki;Miyuki Kimura

  • Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain

    Hiroyuki Kusuhara;Takashi Sekine;Naoko Utsunomiya-Tate;Minoru Tsuda

  • Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.

    Seok Ho Cha;Takashi Sekine;Hiroyuki Kusuhara;Hiroyuki Kusuhara;Erkang Yu

  • Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin

    De-Sheng Wang;Johan W. Jonker;Yukio Kato;Hiroyuki Kusuhara

  • Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

    Takao Watanabe;Hiroyuki Kusuhara;Kazuya Maeda;Yoshihisa Shitara

  • Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone

    Hiroshi Kodaira;Hiroyuki Kusuhara;Junko Ushiki;Eiichi Fuse

  • Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir.

    Tomoki Imaoka;Hiroyuki Kusuhara;Masashi Adachi;John D. Schuetz

  • Functional Characterization of Rat Brain-specific Organic Anion Transporter (Oatp14) at the Blood-Brain Barrier HIGH AFFINITY TRANSPORTER FOR THYROXINE

    Daisuke Sugiyama;Hiroyuki Kusuhara;Hirokazu Taniguchi;Shumpei Ishikawa

  • Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)

    Koichi Watashi;Ann Sluder;Takuji Daito;Takuji Daito;Satoko Matsunaga

  • Characterization of uremic toxin transport by organic anion transporters in the kidney.

    Tsuneo Deguchi;Hiroyuki Kusuhara;Akira Takadate;Hitoshi Endou

  • Involvement of BCRP (ABCG2) in the Biliary Excretion of Pitavastatin

    Masaru Hirano;Kazuya Maeda;Soichiro Matsushima;Yoshitane Nozaki

  • Active efflux across the blood-brain barrier: role of the solute carrier family.

    Hiroyuki Kusuhara;Yuichi Sugiyama

  • Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP.

    Masashi Iwamoto;Koichi Watashi;Koichi Watashi;Senko Tsukuda;Hussein Hassan Aly

  • In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney.

    Hiroyuki Kusuhara;Yuichi Sugiyama

  • Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens.

    Junichi Enokizono;Hiroyuki Kusuhara;Yuichi Sugiyama

  • Characterization of the Efflux Transport of 17β-Estradiol-d-17β-glucuronide from the Brain across the Blood-Brain Barrier

    Daisuke Sugiyama;Hiroyuki Kusuhara;Yoshihisa Shitara;Takaaki Abe

  • Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidney

    Sumito Ito;Hiroyuki Kusuhara;Miyu Yokochi;Junko Toyoshima

  • Quantitative Evaluation of the Therapeutic Effects of Antibiotics Using Silkworms Infected with Human Pathogenic Microorganisms

    Hiroshi Hamamoto;Kenji Kurokawa;Chikara Kaito;Koushirou Kamura

  • Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney.

    Hiroyuki Kusuhara;Yuichi Sugiyama

  • Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier. High affinity transporter for thyroxine. Vol. 278 (2003) 43489-43495

    Daisuke Sugiyama;Hiroyuki Kusuhara;Hirokazu Taniguchi;Shumpei Ishikawa

Frequent Co-Authors

Yuichi Sugiyama
Yuichi Sugiyama University of Tokyo
Hitoshi Endou
Hitoshi Endou Kyorin University
Hiroshi Suzuki
Hiroshi Suzuki Obihiro University of Agriculture and Veterinary Medicine
John D. Schuetz
John D. Schuetz St. Jude Children's Research Hospital
Yasuyoshi Watanabe
Yasuyoshi Watanabe Osaka Metropolitan University
Tetsuya Suhara
Tetsuya Suhara National Institutes for Quantum and Radiological Science and Technology
Yoshinori Moriyama
Yoshinori Moriyama Okayama University
Kozo Takayama
Kozo Takayama Josai University
Hiroshi Ito
Hiroshi Ito Fukushima Medical University
Koichi Watashi
Koichi Watashi National Institute of Infectious Diseases

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