2026 Sumio Ohtsuki: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	79	4394	4052	289	271	276	18727

Overview

Sumio Ohtsuki is affiliated with Kumamoto University in Japan. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with 97 and 72 publications respectively in these areas. Their subfields of study include molecular biology, oncology, neurology, spectroscopy, and cell biology.

Their work broadly covers multiple main topics such as:

Barrier Structure and Function Studies
Advanced Proteomics Techniques and Applications
Metabolomics and Mass Spectrometry Studies
Drug Transport and Resistance Mechanisms
Mass Spectrometry Techniques and Applications
Amino Acid Enzymes and Metabolism
Protein Degradation and Inhibitors

Sumio Ohtsuki has published papers in several well-known venues. Frequent publication venues include:

Drug Metabolism and Pharmacokinetics
Pharmaceutical Research
Fluids and Barriers of the CNS
Molecular Pharmaceutics
Biological and Pharmaceutical Bulletin

Recent research articles authored by or involving Sumio Ohtsuki include:

"Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling," 2020, Proceedings of the National Academy of Sciences
"Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo," 2020, Journal of Controlled Release
"Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma," 2021, Blood Cancer Discovery
"Quantitative and targeted proteomics-based identification and validation of drug efficacy biomarkers," 2020, Drug Metabolism and Pharmacokinetics
"COL1A2 inhibition suppresses glioblastoma cell proliferation and invasion," 2022, Journal of Neurosurgery

The scientist collaborates frequently with several co-authors, notably:

Takeshi Masuda (51 collaborations)
Shingo Ito (24 collaborations)
Seiryo Ogata (15 collaborations)
Shingo Ito (13 collaborations)
Mitsutoshi Nakada (7 collaborations)

Best Publications

Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors

Yasuo Uchida;Sumio Ohtsuki;Yuki Katsukura;Chiemi Ikeda

851
Citations
Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria

Junichi Kamiie;Sumio Ohtsuki;Ryo Iwase;Ken Ohmine

662
Citations
Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development.

Sumio Ohtsuki;Tetsuya Terasaki

568
Citations
Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities

Sumio Ohtsuki;Olaf Schaefer;Hirotaka Kawakami;Tae Inoue

559
Citations
Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

Ben C. Collins;Christie L. Hunter;Yansheng Liu;Birgit Schilling

527
Citations
A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro

Satoko Hori;Sumio Ohtsuki;Ken Ichi Hosoya;Emi Nakashima

408
Citations
Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

Ramzi Shawahna;Yasuo Uchida;Xavier Declèves;Sumio Ohtsuki

401
Citations
Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model

Sumio Ohtsuki;Chiemi Ikeda;Yasuo Uchida;Yumi Sakamoto

289
Citations
Role of blood–brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

Sumio Ohtsuki;Hiroshi Asaba;Hitomi Takanaga;Tsuneo Deguchi

287
Citations
Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

Yutaro Hoshi;Yasuo Uchida;Masanori Tachikawa;Takashi Inoue

279
Citations
A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood–brain barrier in ddY, FVB, and C57BL/6J mice

Yasuo Uchida;Masanori Tachikawa;Wataru Obuchi;Yutaro Hoshi

276
Citations
Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys

Katsuaki Ito;Yasuo Uchida;Sumio Ohtsuki;Sanshiro Aizawa

243
Citations
The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain.

Sumio Ohtsuki;Masanori Tachikawa;Hitomi Takanaga;Hidemi Shimizu

228
Citations
Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection.

Hirotaka Kawakami;Sumio Ohtsuki;Junichi Kamiie;Takashi Suzuki

217
Citations
GAT2/BGT-1 as a System Responsible for the Transport of γ-Aminobutyric Acid at the Mouse Blood–Brain Barrier:

Hitomi Takanaga;Sumio Ohtsuki;Ken Ichi Hosoya;Tetsuya Terasaki

209
Citations
Conditionally immortalized retinal capillary endothelial cell lines (TR-iBRB) expressing differentiated endothelial cell functions derived from a transgenic rat.

Ken-Ichi Hosoya;Masatoshi Tomi;Sumio Ohtsuki;Hitomi Takanaga

208
Citations
Exogenous expression of claudin-5 induces barrier properties in cultured rat brain capillary endothelial cells.

Sumio Ohtsuki;Saori Sato;Hirofumi Yamaguchi;Mayu Kamoi

206
Citations
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney

Tsuneo Deguchi;Sumio Ohtsuki;Sumio Ohtsuki;Masaki Otagiri;Masaki Otagiri;Hitomi Takanaga;Hitomi Takanaga

199
Citations
New approaches to in vitro models of blood-brain barrier drug transport.

Tetsuya Terasaki;Sumio Ohtsuki;Satoko Hori;Hitomi Takanaga

198
Citations
Rat Organic Anion Transporter 3 (rOAT3) is Responsible for Brain-to-Blood Efflux of Homovanillic Acid at the Abluminal Membrane of Brain Capillary Endothelial Cells:

Shinobu Mori;Hitomi Takanaga;Hitomi Takanaga;Sumio Ohtsuki;Sumio Ohtsuki;Tsuneo Deguchi

193
Citations