Ken-ichi Hosoya

What is he best known for?

The fields of study he is best known for:

• Enzyme
• Gene
• Biochemistry

Blood–brain barrier, Endothelial stem cell, Biochemistry, Blood–retinal barrier and Efflux are his primary areas of study. Ken Ichi Hosoya has researched Blood–brain barrier in several fields, including Gene expression and Aspartic acid. His work deals with themes such as Cell growth, Proteoglycan, Cell biology, Internalization and Taurine, which intersect with Endothelial stem cell.

The various areas that he examines in his Biochemistry study include Molecular biology and Biophysics. His Blood–retinal barrier research integrates issues from Transporter, Retina, Glucose transporter, Vitamin C and Sodium-Coupled Vitamin C Transporters. His work in Retina addresses subjects such as Retinal, which are connected to disciplines such as Tight junction.

His most cited work include:

• A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro (259 citations)
• Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. (201 citations)
• Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. (172 citations)

What are the main themes of his work throughout his whole career to date?

Ken Ichi Hosoya spends much of his time researching Blood–retinal barrier, Biochemistry, Cell biology, Endothelial stem cell and Blood–brain barrier. His Blood–retinal barrier study incorporates themes from Biophysics, Retinal, Verapamil, Membrane transport protein and Retina. The concepts of his Cell biology study are interwoven with issues in Pericyte, Immunology, GLUT1 and Immortalised cell line.

Within one scientific family, Ken Ichi Hosoya focuses on topics pertaining to Molecular biology under Endothelial stem cell, and may sometimes address concerns connected to Gene expression. His Blood–brain barrier research incorporates themes from Efflux and Pharmacology. His work carried out in the field of Endocrinology brings together such families of science as Receptor and Cerebrospinal fluid.

He most often published in these fields:

• Blood–retinal barrier (31.47%)
• Biochemistry (30.28%)
• Cell biology (27.09%)

What were the highlights of his more recent work (between 2014-2021)?

• Blood–retinal barrier (31.47%)
• Pharmacology (14.34%)
• Transporter (20.32%)

In recent papers he was focusing on the following fields of study:

Ken Ichi Hosoya mainly focuses on Blood–retinal barrier, Pharmacology, Transporter, Cell biology and Retina. His Blood–retinal barrier research is multidisciplinary, incorporating perspectives in Biophysics, Biochemistry, Verapamil, Molecular biology and Confocal microscopy. His Pharmacology study combines topics from a wide range of disciplines, such as Blood–brain barrier, Brain uptake, Membrane transport protein, Organic cation transport proteins and Efflux.

The Transporter study combines topics in areas such as Immunostaining and Transfection. His research in the fields of Extracellular overlaps with other disciplines such as Phosphocreatine. His Retina research is multidisciplinary, incorporating elements of Retinal, Messenger RNA, Glutamate aspartate transporter and Drug.

Between 2014 and 2021, his most popular works were:

• Contribution of Pannexin 1 and Connexin 43 Hemichannels to Extracellular Calcium–Dependent Transport Dynamics in Human Blood-Brain Barrier Endothelial Cells (30 citations)
• Beta-2 Adrenergic Agonists Are Substrates and Inhibitors of Human Organic Cation Transporter 1. (25 citations)
• Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis. (24 citations)

In his most recent research, the most cited papers focused on:

• Enzyme
• Gene
• Biochemistry

His primary areas of investigation include Blood–retinal barrier, Pharmacology, Organic cation transport proteins, Retina and Blood–brain barrier. He has included themes like Biochemistry, Osmolyte, Retinal pigment epithelium, Biophysics and Molecular biology in his Blood–retinal barrier study. His study in Pharmacology is interdisciplinary in nature, drawing from both Choline, Bioinformatics, Membrane transport protein, Efflux and Nicotine.

His Organic cation transport proteins study combines topics in areas such as Pharmaceutical sciences, Internal medicine and ATP-binding cassette transporter. His study looks at the intersection of Retina and topics like Retinal with In vitro, Distribution and L-Type Amino Acid Transporter. His Blood–brain barrier research is under the purview of Endocrinology.