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D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
15340
World Ranking
6764
National Ranking
484

Overview

Gert Fricker is affiliated with Heidelberg University in Germany and has an extensive publication record in the fields of medicine and biochemistry, genetics, and molecular biology. Their research primarily focuses on topics related to drug transport mechanisms, nanoparticle-based drug delivery, and advanced drug delivery systems, with additional work in oncology, molecular biology, and pharmaceutical science.

Their recent publications reflect a concentrated interest in drug delivery challenges particularly concerning the blood-brain barrier and anticancer therapies. Notable papers include:

  • Targeting Transporters for Drug Delivery to the Brain: Can We Do Better? (2022), published in Pharmaceutical Research
  • The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy (2023), published in Pharmaceutics
  • Blood-brain barrier models: Rationale for selection (2021), published in Advanced Drug Delivery Reviews
  • Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model (2022), published in Neuroscience
  • Crossing the blood-brain barrier: A review on drug delivery strategies using colloidal carrier systems (2021), published in Neurochemistry International

Their frequent co-authors include Elena Puris, Philipp Uhl, Björn Wängler, Mikko Gynther, and Ralf Schirrmacher, indicating collaborative work across multiple studies, often related to pharmacology and drug delivery.

Gert Fricker's research appears regularly in the following publication venues:

  • Pharmaceuticals
  • Pharmaceutics
  • European Journal of Pharmaceutics and Biopharmaceutics
  • Fluids and Barriers of the CNS
  • Environmental Toxicology and Pharmacology

Their work is distributed among subfields such as molecular biology, oncology, radiology, nuclear medicine and imaging, physiology, and pharmaceutical science. The main topics they focus on include:

  • Drug Transport and Resistance Mechanisms
  • Nanoparticle-Based Drug Delivery
  • Alzheimer's Disease Research and Treatments
  • Advanced Drug Delivery Systems
  • RNA Interference and Gene Delivery
  • Radiopharmaceutical Chemistry and Applications
  • Barrier Structure and Function Studies

This profile demonstrates an interdisciplinary approach integrating molecular biology, pharmaceutical sciences, and medical applications primarily aimed at improving drug delivery systems and understanding biological barriers such as the blood-brain barrier. Their scholarly output spans more than ninety publications in medicine and nearly fifty in biochemistry and related fields, evidencing sustained research activity over recent years.

Best Publications

  • Engaging neuroscience to advance translational research in brain barrier biology

    Edward A. Neuwelt;Björn Bauer;Christoph Fahlke;Gert Fricker

  • Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

    Stephan Fellner;Björn Bauer;David S. Miller;Martina Schaffrik

  • Phospholipids and lipid-based formulations in oral drug delivery.

    Gert Fricker;Torsten Kromp;Armin Wendel;Alfred Blume

  • Xenobiotic Transport across Isolated Brain Microvessels Studied by Confocal Microscopy

    David S. Miller;Stephanie N. Nobmann;Heike Gutmann;Michael Toeroek

  • Pregnane X Receptor Up-Regulation of P-Glycoprotein Expression and Transport Function at the Blood-Brain Barrier

    Björn Bauer;Anika M S Hartz;Gert Fricker;David S Miller

  • Relevance of p‐glycoprotein for the enteral absorption of cyclosporin A: in vitro‐in vivo correlation

    G. Fricker;J. Drewe;J. Huwyler;H. Gutmann

  • Rapid Modulation of P-Glycoprotein-Mediated Transport at the Blood-Brain Barrier by Tumor Necrosis Factor-α and Lipopolysaccharide

    Anika M. S. Hartz;Björn Bauer;Gert Fricker;David S. Miller

  • Interactions of HIV Protease Inhibitors with ATP-Dependent Drug Export Proteins

    Heike Gutmann;Gert Fricker;Jürgen Drewe;Michael Toeroek

  • Intracerebral accumulation of glutaric and 3-hydroxyglutaric acids secondary to limited flux across the blood-brain barrier constitute a biochemical risk factor for neurodegeneration in glutaryl-CoA dehydrogenase deficiency.

    Sven W. Sauer;Jürgen G. Okun;Gert Fricker;Anne Mahringer

  • Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar

    Matthias Kühnle;Michael Egger;Christine Müller;Anne Mahringer

  • HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833

    Jürgen Drewe;Heike Gutmann;Gert Fricker;Michael Török

  • Biopharmaceutical classification of poorly soluble drugs with respect to “enabling formulations”

    Stephen Timothy Buckley;Kerstin Julia Frank;Gert Fricker;Martin Brandl

  • Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake.

    Heike Gutmann;Gert Fricker;Michael Török;Susanne Michael

  • Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats.

    Caroline MacLean;Ursula Moenning;Andreas Reichel;Gert Fricker

  • Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver.

    R Bossard;B Stieger;B O'Neill;G Fricker

  • Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer’s disease treatment

    Joana A. Loureiro;Bárbara Gomes;Gert Fricker;Manuel A. N. Coelho

  • Modulation of p-glycoprotein transport function at the blood-brain barrier.

    Björn Bauer;Anika M. S. Hartz;Anika M. S. Hartz;Gert Fricker;David S. Miller

  • Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1.

    Anika M. S. Hartz;Björn Bauer;Gert Fricker;David S. Miller

  • Matrix-loaded biodegradable gelatin nanoparticles as new approach to improve drug loading and delivery.

    Kenneth Ofokansi;Gerhard Winter;Gert Fricker;Conrad Coester;Conrad Coester

  • ABC transporters at the blood-brain barrier.

    Anne Mahringer;Gert Fricker

Frequent Co-Authors

Walter Mier
Walter Mier University Hospital Heidelberg
Melanie Ott
Melanie Ott Gladstone Institutes
Christoph Beglinger
Christoph Beglinger University of Basel
Thomas Efferth
Thomas Efferth Johannes Gutenberg University of Mainz
James L. Boyer
James L. Boyer Yale University
Wolfgang Stremmel
Wolfgang Stremmel Heidelberg University
Wolfgang Gerok
Wolfgang Gerok University of Freiburg
Thomas Kissel
Thomas Kissel Philipp University of Marburg
Gerhard Eisenbrand
Gerhard Eisenbrand Technical University of Kaiserslautern
Alexander Thiel
Alexander Thiel McGill University

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