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Tetsuya Terasaki

Tetsuya Terasaki

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
97
Citations
29048
World Ranking
1776
National Ranking
97

Medicine

D-Index
97
Citations
29000
World Ranking
9416
National Ranking
253

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Tetsuya Terasaki is affiliated with Tohoku University in Japan and has an extensive publication record in medical and molecular biology research fields. Their work covers a strong focus on drug transport and resistance mechanisms, amino acid enzymes and metabolism, and barrier structure and function studies, among other related topics.

Their research spans various subfields, including oncology, molecular biology, biochemistry, neurology, and aspects of pediatrics and perinatology. This multidisciplinary approach assists in addressing complex biological and medical challenges through proteomics and pharmacological studies.

Frequent coauthors in Terasaki's body of work include Yasuo Uchida, Ahmed B. Montaser, Masanori Tachikawa, Kristiina M. Huttunen, and Arto Urtti. These collaborations have contributed to an ongoing stream of scientific publications.

The scientist regularly publishes in venues such as Molecular Pharmaceutics, Pharmaceutical Research, Journal of Controlled Release, Pharmaceutics, and Journal of Neurochemistry. These journals reflect the focus on pharmacology, molecular pharmaceutics, and neurochemistry within their research.

Recent papers include the following:

  • Comparison of Absolute Protein Abundances of Transporters and Receptors among Blood-Brain Barriers at Different Cerebral Regions and the Blood-Spinal Cord Barrier in Humans and Rats, 2020, Molecular Pharmaceutics
  • Quantitative Targeted Absolute Proteomics for Better Characterization of an In Vitro Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells, 2022, Cells
  • Selective drug delivery to the retinal cells: Biological barriers and avenues, 2023, Journal of Controlled Release
  • Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery, 2022, Pharmaceutical Research
  • Gelsolin inhibits malignant phenotype of glioblastoma and is regulated by miR-654-5p and miR-450b-5p, 2020, Cancer Science

Tetsuya Terasaki's research addresses main topics such as:

  • Drug Transport and Resistance Mechanisms
  • Amino Acid Enzymes and Metabolism
  • Barrier Structure and Function Studies
  • Pharmacological Effects and Toxicity Studies
  • Metabolism and Genetic Disorders
  • Epilepsy research and treatment
  • Diet and metabolism studies

The combination of these research themes places Terasaki's work at the intersection of medicine and biochemistry with a detailed molecular focus on how biological barriers influence drug delivery and brain pharmacoproteomics. The research contributes to understanding the molecular basis of transporter protein function and disease mechanisms across neurological and oncological contexts.

Best Publications

  • Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors

    Yasuo Uchida;Sumio Ohtsuki;Yuki Katsukura;Chiemi Ikeda

  • Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria

    Junichi Kamiie;Sumio Ohtsuki;Ryo Iwase;Ken Ohmine

  • Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development.

    Sumio Ohtsuki;Tetsuya Terasaki

  • Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities

    Sumio Ohtsuki;Olaf Schaefer;Hirotaka Kawakami;Tae Inoue

  • In vitro models for the blood-brain barrier.

    P. Garberg;M. Ball;N. Borg;R. Cecchelli

  • A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro

    Satoko Hori;Sumio Ohtsuki;Ken Ichi Hosoya;Emi Nakashima

  • Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

    Ramzi Shawahna;Yasuo Uchida;Xavier Declèves;Sumio Ohtsuki

  • P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells.

    Akira Tsuji;Tetsuya Terasaki;Yasushi Takabatake;Yoshiyuki Tenda

  • Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy.

    Ermelindo C Leal;Ayyakkannu Manivannan;Ken-Ichi Hosoya;Tetsuya Terasaki

  • Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model

    Sumio Ohtsuki;Chiemi Ikeda;Yasuo Uchida;Yumi Sakamoto

  • Role of blood–brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

    Sumio Ohtsuki;Hiroshi Asaba;Hitomi Takanaga;Tsuneo Deguchi

  • Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

    Yutaro Hoshi;Yasuo Uchida;Masanori Tachikawa;Takashi Inoue

  • A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood–brain barrier in ddY, FVB, and C57BL/6J mice

    Yasuo Uchida;Masanori Tachikawa;Wataru Obuchi;Yutaro Hoshi

  • Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier.

    Atsuyuki Kakee;Tetsuya Terasaki;Yuichi Sugiyama

  • Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions.

    Lorena Perrone;Takhellambam S. Devi;Ken Ichi Hosoya;Tetsuya Terasaki

  • In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors.

    Akira Saheki;Tetsuya Terasaki;Ikumi Tamai;Akira Tsuji

  • Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys

    Katsuaki Ito;Yasuo Uchida;Sumio Ohtsuki;Sanshiro Aizawa

  • Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier

    Weihong Pan;Abba J. Kastin;Todd C. Zankel;Peter van Kerkhof

  • The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain.

    Sumio Ohtsuki;Masanori Tachikawa;Hitomi Takanaga;Hidemi Shimizu

  • Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein

    Akira Tsuji;Ikumi Tamai;Atsushi Sakata;Yoshiyuki Tenda

Frequent Co-Authors

Sumio Ohtsuki
Sumio Ohtsuki Kumamoto University
Ken-ichi Hosoya
Ken-ichi Hosoya University of Toyama
Masanori Tachikawa
Masanori Tachikawa University of Tokushima
Yuichi Sugiyama
Yuichi Sugiyama University of Tokyo
Ikumi Tamai
Ikumi Tamai Kanazawa University
Masuo Obinata
Masuo Obinata Tohoku University
Hiroshi Suzuki
Hiroshi Suzuki Obihiro University of Agriculture and Veterinary Medicine
Masahiko Watanabe
Masahiko Watanabe Hokkaido University
Takaaki Abe
Takaaki Abe Tohoku University
Michiaki Unno
Michiaki Unno Tohoku University

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