World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
144
Citations
72643
World Ranking
230
National Ranking
159

Medicine

D-Index
147
Citations
73564
World Ranking
1302
National Ranking
751

Overview

William M. Pardridge was affiliated with the University of California, Los Angeles in the United States. Their research primarily focused on the intersection of biochemistry, genetics, molecular biology, and medicine, with substantial contributions to molecular biology and physiology.

Their work extensively covered subfields including molecular biology, physiology, neurology, radiology, nuclear medicine, imaging, and biomaterials. Key research topics involved RNA interference and gene delivery, advanced biosensing and bioanalysis techniques, nanoparticle-based drug delivery, virus-based gene therapy research, monoclonal and polyclonal antibodies research, drug transport and resistance mechanisms, as well as barrier structure and function studies.

William M. Pardridge's publications appeared frequently in journals such as Pharmaceutics, Pharmaceuticals, Frontiers in Aging Neuroscience, Molecular Pharmaceutics, and Scientific Reports. Notable recent papers include:

  • "Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain" (2020) published in Frontiers in Aging Neuroscience
  • "A Historical Review of Brain Drug Delivery" (2022) published in Pharmaceutics
  • "Treatment of Alzheimer's Disease and Blood-Brain Barrier Drug Delivery" (2020) published in Pharmaceuticals
  • "Plasmid DNA gene therapy of the Niemann-Pick C1 mouse with transferrin receptor-targeted Trojan horse liposomes" (2020) published in Scientific Reports
  • "The Isolated Brain Microvessel: A Versatile Experimental Model of the Blood-Brain Barrier" (2020) published in Frontiers in Physiology

Their research collaborations included frequent coauthors such as Dahai Jiang, Hungyen Lee, Demi M. Castellanos, Jiahong Sun, and Joshua Yang.

Best Publications

  • The Blood-Brain Barrier: Bottleneck in Brain Drug Development

    William M. Pardridge

  • Drug transport across the blood-brain barrier.

    William M Pardridge

  • Blood-brain barrier delivery.

    William M. Pardridge

  • Brain metabolism: a perspective from the blood-brain barrier

    W. M. Pardridge

  • Blood-brain barrier drug targeting: the future of brain drug development.

    William M. Pardridge

  • Brain drug delivery of small molecules using immunoliposomes

    Joerg Huwyler;Dafang Wu;William M. Pardridge

  • Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization.

    W M Pardridge;R J Boado;C R Farrell

  • Transport of metabolic substrates through the blood-brain barrier.

    William M. Pardridge;William H. Oldendorf

  • Drug and gene targeting to the brain with molecular Trojan horses.

    William M. Pardridge

  • Delivery of peptides and proteins through the blood-brain barrier.

    Ulrich Bickel;Takayoshi Yoshikawa;William M. Pardridge

  • CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport

    William M. Pardridge

  • Blood-brain barrier biology and methodology

    William M Pardridge

  • Non-invasive gene targeting to the brain

    William M. Pardrige

  • Capillary Depletion Method for Quantification of Blood–Brain Barrier Transport of Circulating Peptides and Plasma Proteins

    Domingo Triguero;Jody Buciak;William M. Pardridge

  • Transport of protein-bound hormones into tissues in vivo.

    William M. Pardridge

  • Drug Targeting to the Brain

    William M. Pardridge

  • Strategies to advance translational research into brain barriers

    Edward Neuwelt;N Joan Abbott;Lauren Abrey;William A Banks

  • Transport of Steroid Hormones Through the Rat Blood-Brain Barrier. Primary Role of Albumin-Bound Hormone

    William M. Pardridge;Lawrence J. Mietus

  • Selective expression of the large neutral amino acid transporter at the blood-brain barrier.

    Ruben J. Boado;Jian Yi Li;Marie Nagaya;Crystal Zhang

  • Human blood-brain barrier insulin receptor.

    William M. Pardridge;Jody Eisenberg;Jing Yang

Frequent Co-Authors

Ruben J. Boado
Ruben J. Boado University of California, Los Angeles
Harry V. Vinters
Harry V. Vinters University of California, Los Angeles
Gautam Chaudhuri
Gautam Chaudhuri University of California, Los Angeles
Roberto Giugliani
Roberto Giugliani Federal University of Rio Grande do Sul
David H. Cribbs
David H. Cribbs University of California, Irvine
Tetsuya Terasaki
Tetsuya Terasaki Tohoku University
Keith L. Black
Keith L. Black Cedars-Sinai Medical Center
Eric V. Shusta
Eric V. Shusta University of Wisconsin–Madison
Ron G. Rosenfeld
Ron G. Rosenfeld Oregon Health & Science University
Sherie L. Morrison
Sherie L. Morrison University of California, Los Angeles

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