2023 - Research.com Medicine in Japan Leader Award
Yuichi Sugiyama mainly focuses on Pharmacology, Biochemistry, Pharmacokinetics, Transporter and Organic anion transporter 1. His Pharmacology study combines topics from a wide range of disciplines, such as Efflux, In vitro, In vivo and Pravastatin. His Biochemistry study frequently links to related topics such as Molecular biology.
His Pharmacokinetics research is multidisciplinary, relying on both Oral administration, Plasma protein binding, Drug metabolism, Hepatocyte and Distribution. The various areas that Yuichi Sugiyama examines in his Transporter study include Metabolite, Cyclosporin a and Intracellular. In his study, which falls under the umbrella issue of Organic anion transporter 1, Cimetidine is strongly linked to Kidney metabolism.
Yuichi Sugiyama mainly investigates Pharmacology, Biochemistry, Pharmacokinetics, Internal medicine and Endocrinology. Yuichi Sugiyama has researched Pharmacology in several fields, including P-glycoprotein, Efflux, Transporter and In vivo. His research in In vivo intersects with topics in Microsome, In vitro and Metabolism.
Biochemistry is frequently linked to Molecular biology in his study. His Pharmacokinetics research incorporates themes from Metabolite, Distribution, Drug metabolism and Oral administration. He interconnects Abcg2 and Multidrug resistance-associated protein 2 in the investigation of issues within Internal medicine.
His main research concerns Pharmacology, Pharmacokinetics, Transporter, Drug and In vivo. His research in Pharmacology intersects with topics in In vitro, Endogeny, Biochemistry, Organic anion transporter 1 and Organic anion-transporting polypeptide. Yuichi Sugiyama combines subjects such as MicroDose, CYP3A4, Cytochrome P450 and Oral administration with his study of Pharmacokinetics.
His work in Transporter addresses subjects such as Intestinal absorption, which are connected to disciplines such as P-glycoprotein. His study in In vivo is interdisciplinary in nature, drawing from both Metformin and Albumin. He has researched Abcg2 in several fields, including Endocrinology and Internal medicine.
Pharmacology, Pharmacokinetics, In vivo, Drug and Organic anion transporter 1 are his primary areas of study. His Pharmacology research integrates issues from Metformin, Organic anion-transporting polypeptide, Transporter, Rifampicin and Endogeny. His Organic anion-transporting polypeptide study improves the overall literature in Biochemistry.
His biological study spans a wide range of topics, including Metabolite, Fexofenadine, Repaglinide and Distribution. His In vivo research is multidisciplinary, incorporating elements of Pitavastatin, In vitro and Stem cell. The concepts of his Organic anion transporter 1 study are interwoven with issues in Cell culture, Probenecid, Benzylpenicillin, Pravastatin and HMG-CoA reductase.
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen.
Archives of Toxicology (2013)
Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions
Yoshihisa Shitara;Yuichi Sugiyama.
Pharmacology & Therapeutics (2006)
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.
Yohei Nishizato;Ichiro Ieiri;Hiroshi Suzuki;Miyuki Kimura.
Clinical Pharmacology & Therapeutics (2003)
Novel Cisplatin-Incorporated Polymeric Micelles Can Eradicate Solid Tumors in Mice
Nobuhiro Nishiyama;Souichiro Okazaki;Horacio Cabral;Masaki Miyamoto.
Cancer Research (2003)
Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain
Hiroyuki Kusuhara;Takashi Sekine;Naoko Utsunomiya-Tate;Minoru Tsuda.
Journal of Biological Chemistry (1999)
Impact of Drug Transporter Studies on Drug Discovery and Development
Naomi Mizuno;Takuro Niwa;Yoshihisa Yotsumoto;Yuichi Sugiyama.
Pharmacological Reviews (2003)
Transporters as a determinant of drug clearance and tissue distribution.
Yoshihisa Shitara;Toshiharu Horie;Yuichi Sugiyama.
European Journal of Pharmaceutical Sciences (2006)
Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.
K. Ito;T. Iwatsubo;S. Kanamitsu;K. Ueda.
Pharmacological Reviews (1998)
Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.
Seok Ho Cha;Takashi Sekine;Hiroyuki Kusuhara;Hiroyuki Kusuhara;Erkang Yu.
Journal of Biological Chemistry (2000)
Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data
Takafumi Iwatsubo;Noriko Hirota;Tsuyoshi Ooie;Hiroshi Suzuki.
Pharmacology & Therapeutics (1997)
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