Yuichi Sugiyama

Research.com Recognitions

• 2023 - Research.com Medicine in Japan Leader Award

Overview

Best Publications

• Membrane transporters in drug development.

  Kathleen M. Giacomini;Shiew Mei Huang;Donald J. Tweedie;Leslie Z. Benet

  3316
  Citations

• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

  Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen

  1158
  Citations

• Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions

  Yoshihisa Shitara;Yuichi Sugiyama

  792
  Citations

• Novel Cisplatin-Incorporated Polymeric Micelles Can Eradicate Solid Tumors in Mice

  Nobuhiro Nishiyama;Souichiro Okazaki;Horacio Cabral;Masaki Miyamoto

  770
  Citations

• Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.

  Yohei Nishizato;Ichiro Ieiri;Hiroshi Suzuki;Miyuki Kimura

  746
  Citations

• Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain

  Hiroyuki Kusuhara;Takashi Sekine;Naoko Utsunomiya-Tate;Minoru Tsuda

  716
  Citations

• Impact of Drug Transporter Studies on Drug Discovery and Development

  Naomi Mizuno;Takuro Niwa;Yoshihisa Yotsumoto;Yuichi Sugiyama

  697
  Citations

• Transporters as a determinant of drug clearance and tissue distribution.

  Yoshihisa Shitara;Toshiharu Horie;Yuichi Sugiyama

  683
  Citations

• Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.

  K. Ito;T. Iwatsubo;S. Kanamitsu;K. Ueda

  643
  Citations

• Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.

  Seok Ho Cha;Takashi Sekine;Hiroyuki Kusuhara;Hiroyuki Kusuhara;Erkang Yu

  583
  Citations

• Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

  Takafumi Iwatsubo;Noriko Hirota;Tsuyoshi Ooie;Hiroshi Suzuki

  579
  Citations

• Gemfibrozil and Its Glucuronide Inhibit the Organic Anion Transporting Polypeptide 2 (OATP2/OATP1B1:SLC21A6)-Mediated Hepatic Uptake and CYP2C8-Mediated Metabolism of Cerivastatin: Analysis of the Mechanism of the Clinically Relevant Drug-Drug Interaction between Cerivastatin and Gemfibrozil

  Yoshihisa Shitara;Masaru Hirano;Hitoshi Sato;Yuichi Sugiyama

  567
  Citations

• Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin

  De-Sheng Wang;Johan W. Jonker;Yukio Kato;Hiroyuki Kusuhara

  556
  Citations

• Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge.

  Yuji Yamamoto;Yukio Nagasaki;Yukio Kato;Yuichi Sugiyama

  551
  Citations

• Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

  Masaru Hirano;Kazuya Maeda;Yoshihisa Shitara;Yuichi Sugiyama

  513
  Citations

• Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).

  Tomoko Hirohashi;Hiroshi Suzuki;Yuichi Sugiyama

  494
  Citations

• EVALUATION OF DRUG-DRUG INTERACTION IN THE HEPATOBILIARY AND RENAL TRANSPORT OF DRUGS

  Yoshihisa Shitara;Hitoshi Sato;Yuichi Sugiyama

  459
  Citations

• ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3).

  Tomoko Hirohashi;Hiroshi Suzuki;Hajime Takikawa;Yuichi Sugiyama

  458
  Citations

• Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption.

  Yoshihisa Shitara;Kazuya Maeda;Kazuaki Ikejiri;Kenta Yoshida

  422
  Citations

• Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A

  Yoshihisa Shitara;Tomoo Itoh;Hitoshi Sato;Albert P. Li

  420
  Citations