D-Index & Metrics Best Publications
Medicine
Japan
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 133 Citations 59,611 842 World Ranking 1254 National Ranking 22

Research.com Recognitions

Awards & Achievements

2023 - Research.com Medicine in Japan Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Enzyme
  • Gene

Yuichi Sugiyama mainly focuses on Pharmacology, Biochemistry, Pharmacokinetics, Transporter and Organic anion transporter 1. His Pharmacology study combines topics from a wide range of disciplines, such as Efflux, In vitro, In vivo and Pravastatin. His Biochemistry study frequently links to related topics such as Molecular biology.

His Pharmacokinetics research is multidisciplinary, relying on both Oral administration, Plasma protein binding, Drug metabolism, Hepatocyte and Distribution. The various areas that Yuichi Sugiyama examines in his Transporter study include Metabolite, Cyclosporin a and Intracellular. In his study, which falls under the umbrella issue of Organic anion transporter 1, Cimetidine is strongly linked to Kidney metabolism.

His most cited work include:

  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (760 citations)
  • Novel Cisplatin-Incorporated Polymeric Micelles Can Eradicate Solid Tumors in Mice (502 citations)
  • Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions (481 citations)

What are the main themes of his work throughout his whole career to date?

Yuichi Sugiyama mainly investigates Pharmacology, Biochemistry, Pharmacokinetics, Internal medicine and Endocrinology. Yuichi Sugiyama has researched Pharmacology in several fields, including P-glycoprotein, Efflux, Transporter and In vivo. His research in In vivo intersects with topics in Microsome, In vitro and Metabolism.

Biochemistry is frequently linked to Molecular biology in his study. His Pharmacokinetics research incorporates themes from Metabolite, Distribution, Drug metabolism and Oral administration. He interconnects Abcg2 and Multidrug resistance-associated protein 2 in the investigation of issues within Internal medicine.

He most often published in these fields:

  • Pharmacology (41.45%)
  • Biochemistry (28.27%)
  • Pharmacokinetics (27.93%)

What were the highlights of his more recent work (between 2012-2021)?

  • Pharmacology (41.45%)
  • Pharmacokinetics (27.93%)
  • Transporter (17.09%)

In recent papers he was focusing on the following fields of study:

His main research concerns Pharmacology, Pharmacokinetics, Transporter, Drug and In vivo. His research in Pharmacology intersects with topics in In vitro, Endogeny, Biochemistry, Organic anion transporter 1 and Organic anion-transporting polypeptide. Yuichi Sugiyama combines subjects such as MicroDose, CYP3A4, Cytochrome P450 and Oral administration with his study of Pharmacokinetics.

His work in Transporter addresses subjects such as Intestinal absorption, which are connected to disciplines such as P-glycoprotein. His study in In vivo is interdisciplinary in nature, drawing from both Metformin and Albumin. He has researched Abcg2 in several fields, including Endocrinology and Internal medicine.

Between 2012 and 2021, his most popular works were:

  • Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (760 citations)
  • Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption. (261 citations)
  • Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver (169 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Internal medicine
  • Gene

Pharmacology, Pharmacokinetics, In vivo, Drug and Organic anion transporter 1 are his primary areas of study. His Pharmacology research integrates issues from Metformin, Organic anion-transporting polypeptide, Transporter, Rifampicin and Endogeny. His Organic anion-transporting polypeptide study improves the overall literature in Biochemistry.

His biological study spans a wide range of topics, including Metabolite, Fexofenadine, Repaglinide and Distribution. His In vivo research is multidisciplinary, incorporating elements of Pitavastatin, In vitro and Stem cell. The concepts of his Organic anion transporter 1 study are interwoven with issues in Cell culture, Probenecid, Benzylpenicillin, Pravastatin and HMG-CoA reductase.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen.
Archives of Toxicology (2013)

916 Citations

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions

Yoshihisa Shitara;Yuichi Sugiyama.
Pharmacology & Therapeutics (2006)

764 Citations

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.

Yohei Nishizato;Ichiro Ieiri;Hiroshi Suzuki;Miyuki Kimura.
Clinical Pharmacology & Therapeutics (2003)

735 Citations

Novel Cisplatin-Incorporated Polymeric Micelles Can Eradicate Solid Tumors in Mice

Nobuhiro Nishiyama;Souichiro Okazaki;Horacio Cabral;Masaki Miyamoto.
Cancer Research (2003)

728 Citations

Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain

Hiroyuki Kusuhara;Takashi Sekine;Naoko Utsunomiya-Tate;Minoru Tsuda.
Journal of Biological Chemistry (1999)

711 Citations

Impact of Drug Transporter Studies on Drug Discovery and Development

Naomi Mizuno;Takuro Niwa;Yoshihisa Yotsumoto;Yuichi Sugiyama.
Pharmacological Reviews (2003)

677 Citations

Transporters as a determinant of drug clearance and tissue distribution.

Yoshihisa Shitara;Toshiharu Horie;Yuichi Sugiyama.
European Journal of Pharmaceutical Sciences (2006)

662 Citations

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.

K. Ito;T. Iwatsubo;S. Kanamitsu;K. Ueda.
Pharmacological Reviews (1998)

625 Citations

Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.

Seok Ho Cha;Takashi Sekine;Hiroyuki Kusuhara;Hiroyuki Kusuhara;Erkang Yu.
Journal of Biological Chemistry (2000)

570 Citations

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

Takafumi Iwatsubo;Noriko Hirota;Tsuyoshi Ooie;Hiroshi Suzuki.
Pharmacology & Therapeutics (1997)

565 Citations

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