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Janne T. Backman

Janne T. Backman

D-Index & Metrics

Medicine

D-Index
85
Citations
21480
World Ranking
14779
National Ranking
171

Overview

Janne T. Backman is affiliated with the University of Helsinki in Finland. Their research activity is primarily concentrated in the field of Medicine, with a strong focus on Pharmacology as a key subfield. Additional areas of study include Oncology, Surgery, Pediatrics, Perinatology and Child Health, and Molecular Biology.

Their work is associated with several main topics that revolve around Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Lipoproteins and Cardiovascular Health, Inflammatory mediators and NSAID effects, Pharmacological Effects and Toxicity Studies, Antibiotics Pharmacokinetics and Efficacy, and Computational Drug Discovery Methods.

Janne T. Backman has published in a variety of scientific journals, with frequent publication venues including:

  • Clinical Pharmacology & Therapeutics
  • Basic & Clinical Pharmacology & Toxicology
  • British Journal of Clinical Pharmacology
  • Clinical and Translational Science
  • European Journal of Pharmaceutical Sciences

Recent papers attributed to and associated with Janne T. Backman include:

  • "A comprehensive pharmacogenomic study indicates roles for SLCO1B1, ABCG2 and SLCO2B1 in rosuvastatin pharmacokinetics," 2022, British Journal of Clinical Pharmacology
  • "Genomewide Association Study of Simvastatin Pharmacokinetics," 2022, Clinical Pharmacology & Therapeutics
  • "Performance of Plasma Coproporphyrin I and III as OATP1B1 Biomarkers in Humans," 2021, Clinical Pharmacology & Therapeutics
  • "Febuxostat, But Not Allopurinol, Markedly Raises the Plasma Concentrations of the Breast Cancer Resistance Protein Substrate Rosuvastatin," 2020, Clinical and Translational Science
  • "Effect of High-Dose Esomeprazole on CYP1A2, CYP2C19, and CYP3A4 Activities in Humans: Evidence for Substantial and Long-lasting Inhibition of CYP2C19," 2020, Clinical Pharmacology & Therapeutics

Frequent co-authors in their research collaborations include:

  • Mikko Niemi
  • Mikko Neuvonen
  • Aleksi Tornio
  • Mika Kurkela
  • Outi Lapatto-Reiniluoto

Best Publications

  • Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

    Pertti J. Neuvonen;Mikko Niemi;Janne T. Backman

  • Pharmacokinetic interactions with rifampicin : clinical relevance.

    Mikko Niemi;Janne T. Backman;Martin F. Fromm;Pertti J. Neuvonen

  • SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid.

    Marja K. Pasanen;Mikko Neuvonen;Pertti J. Neuvonen;Mikko Niemi

  • High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).

    Mikko Niemi;Elke Schaeffeler;Thomas Lang;Martin F Fromm

  • Midazolam Should Be Avoided in Patients Receiving the Systemic Antimycotics Ketoconazole or Itraconazole

    K. T. Olkkola;J. T. Backman;P. J. Neuvonen

  • Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics.

    Mikko Niemi;Mikko Niemi;Mikko Niemi;Janne T. Backman;Janne T. Backman;Janne T. Backman;Lauri I. Kajosaari;Lauri I. Kajosaari;Lauri I. Kajosaari;Julian B. Leathart;Julian B. Leathart;Julian B. Leathart

  • Gemfibrozil greatly increases plasma concentrations of cerivastatin.

    Janne T. Backman;Carl Kyrklund;Mikko Neuvonen;Pertti J. Neuvonen

  • Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide

    M. Niemi;J. T. Backman;M. Neuvonen;P. J. Neuvonen

  • Plasma concentrations of active simvastatin acid are increased by gemfibrozil.

    Janne T. Backman;Carl Kyrklund;Kari T. Kivistö;Jun‐Sheng Wang

  • Rifampin drastically reduces plasma concentrations and effects of oral midazolam

    Janne T. Backman;Klaus T. Olkkola;Pertti J. Neuvonen

  • Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers

    Murali Shyamsundar;Scott T. W. McKeown;Cecilia M. O'Kane;Thelma R. Craig

  • The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin.

    J T Backman;K T Kivistö;K T Olkkola;P J Neuvonen

  • Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases.

    Isabel Siegle;Thomas Klein;Janne T. Backman;Johannes G. Saal

  • Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes.

    Jun-Sheng Wang;Mikko Neuvonen;Xia Wen;Janne T. Backman

  • Pharmacokinetic Comparison of the Potential Over-the-Counter Statins Simvastatin, Lovastatin, Fluvastatin and Pravastatin

    Pertti J Neuvonen;Janne T Backman;Mikko Niemi

  • Cyclosporine markedly raises the plasma concentrations of repaglinide.

    Lauri I. Kajosaari;Mikko Niemi;Mikko Neuvonen;Jouko Laitila

  • Metabolism of Repaglinide by CYP2C8 and CYP3A4 in vitro: Effect of Fibrates and Rifampicin

    Lauri I. Kajosaari;Jouko Laitila;Pertti J. Neuvonen;Janne T. Backman

  • The Role of β-Glucuronidase in Drug Disposition and Drug Targeting in Humans

    Bernhard Sperker;Janne T. Backman;Heyo K. Kroemer

  • Trimethoprim and Sulfamethoxazole are Selective Inhibitors of CYP2C8 and CYP2C9, Respectively

    Xia Wen;Jun-Sheng Wang;Janne T. Backman;Jouko Laitila

  • Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

    Janne T. Backman;Anne M. Filppula;Mikko Niemi;Pertti J. Neuvonen

Frequent Co-Authors

Pertti J. Neuvonen
Pertti J. Neuvonen University of Helsinki
Mikko Niemi
Mikko Niemi University of Helsinki
Klaus T. Olkkola
Klaus T. Olkkola University of Helsinki
Michel Eichelbaum
Michel Eichelbaum University of Tübingen
Ann K. Daly
Ann K. Daly Newcastle University
Amin Rostami-Hodjegan
Amin Rostami-Hodjegan University of Manchester
Eija Kalso
Eija Kalso University of Helsinki
Matthias Schwab
Matthias Schwab University of Tübingen
Daniel F. McAuley
Daniel F. McAuley Queen's University Belfast
Heyo K. Kroemer
Heyo K. Kroemer University of Göttingen

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