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Lisa L. von Moltke

Lisa L. von Moltke

D-Index & Metrics

Medicine

D-Index
76
Citations
15877
World Ranking
18939
National Ranking
9441

Overview

Lisa L. von Moltke is affiliated with Tufts University in the United States and has contributed to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work also extends into subfields such as Molecular Biology and Pharmacology.

The scientific topics addressed in von Moltke's research include:

  • Receptor Mechanisms and Signaling
  • Pharmacological Receptor Mechanisms and Effects
  • Treatment of Major Depression

Von Moltke has authored papers that have been published in venues such as the British Journal of Clinical Pharmacology. A recent publication in 2022 is titled "Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers," which appeared in the same journal.

Frequent coauthors collaborating with von Moltke include Francis M. Dijkstra, Rob Zuiker, Pieter Siebenga, Richard Leigh-Pemberton, and Lei Sun.

Best Publications

  • Effects of the antifungal agents on oxidative drug metabolism: clinical relevance.

    Karthik Venkatakrishnan;L. L. von Moltke;L. L. von Moltke;D. J. Greenblatt;D. J. Greenblatt

  • Human drug metabolism and the cytochromes P450: application and relevance of in vitro models.

    Karthik Venkatakrishnan;Lisa L. von Moltke;David J. Greenblatt

  • The influence of age and sex on the clearance of cytochrome P450 3A substrates.

    Monette M. Cotreau;Lisa L. von Moltke;David J. Greenblatt

  • CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

    Leah M. Hesse;Karthik Venkatakrishnan;Michael H. Court;Lisa L. Von Moltke

  • Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine

    Kirk M. Bertelsen;Karthik Venkatakrishnan;Lisa L. von Moltke;R. Scott Obach

  • Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: Effect of ketoconazole

    Shirley M. Tsunoda;Shirley M. Tsunoda;Rebecca L. Velez;Rebecca L. Velez;Lisa L. von Moltke;Lisa L. von Moltke;David J. Greenblatt;David J. Greenblatt

  • EVALUATION OF 3′-AZIDO-3′-DEOXYTHYMIDINE, MORPHINE, AND CODEINE AS PROBE SUBSTRATES FOR UDP-GLUCURONOSYLTRANSFERASE 2B7 (UGT2B7) IN HUMAN LIVER MICROSOMES: SPECIFICITY AND INFLUENCE OF THE UGT2B7*2 POLYMORPHISM

    Michael H. Court;Soundarajan Krishnaswamy;Qin Hao;Su X. Duan

  • Interaction of Warfarin With Drugs, Natural Substances, and Foods

    David J. Greenblatt;Lisa L. von Moltke

  • In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.

    Kiran C. Patki;Lisa L. von Moltke;David J. Greenblatt

  • Midazolam Hydroxylation by Human Liver Microsomes In Vitro: Inhibition by Fluoxetine, Norfluoxetine, and by Azole Antifungal Agents

    Lisa L. von Moltke;David J. Greenblatt;Jürgen Schmider;Su Xiang Duan

  • Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir

    Lisa L. von Moltke;David J. Greenblatt;Jeffrey M. Grassi;Brian W. Granda

  • Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

    Michael H. Court;Su X. Duan;Lisa L. von Moltke;David J. Greenblatt

  • In Vitro Approaches to Predicting Drug Interactions In Vivo

    Lisa L von Moltke;Lisa L von Moltke;David J Greenblatt;David J Greenblatt;Jürgen Schmider;Jürgen Schmider;C.Eugene Wright

  • Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches.

    Karthik Venkatakrishnan;Lisa L. von Moltke;Michael H. Court;Jerold S. Harmatz

  • Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram.

    Lisa L. von Moltke;David J. Greenblatt;Gina M. Giancarlo;Brian W. Granda

  • Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice.

    David J. Greenblatt;Lisa L. von Moltke;Jerold S. Harmatz;Gengsheng Chen

  • Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs) : S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

    Michael H. Court;Su X. Duan;Chantal Guillemette;Kim Journault

  • Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes.

    Leah M Hesse;Ping He;Soundararajan Krishnaswamy;Qin Hao

  • O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants

    Steven M Fogelman;Jürgen Schmider;Karthik Venkatakrishnan;Lisa L von Moltke

  • Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4.

    Karthik Venkatakrishnan;David J. Greenblatt;Lisa L. von Moltke;Jürgen Schmider

Frequent Co-Authors

David J. Greenblatt
David J. Greenblatt Tufts University
Jerold S. Harmatz
Jerold S. Harmatz Tufts University
Richard I. Shader
Richard I. Shader Tufts University
R. Scott Obach
R. Scott Obach Pfizer (United States)
Chantal Guillemette
Chantal Guillemette Université Laval
Jacqueline F. Sinclair
Jacqueline F. Sinclair Dartmouth College
Peter R. Sinclair
Peter R. Sinclair Dartmouth College
Steven A. Wrighton
Steven A. Wrighton Eli Lilly (United States)
Christine Wanke
Christine Wanke Tufts University
Mark Sullivan
Mark Sullivan University of Southampton

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