R. Scott Obach

Best Publications

• An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.

  Dafydd R. Owen;Charlotte M. N. Allerton;Annaliesa S. Anderson;Lisa Aschenbrenner

  1454
  Citations

• The conduct of in vitro and in vivo drug-drug interaction studies: A Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

  Thorir D. Bjornsson;John T. Callaghan;Heidi J. Einolf;Volker Fischer

  922
  Citations

• A comprehensive listing of bioactivation pathways of organic functional groups.

  Amit S. Kalgutkar;Iain Gardner;R. Scott Obach;Christopher L. Shaffer

  700
  Citations

• Validated assays for human cytochrome P450 activities.

  Robert L. Walsky;R. Scott Obach

  694
  Citations

• Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions.

  R. Scott Obach;Robert L. Walsky;Karthik Venkatakrishnan

  611
  Citations

• Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

  R. Scott Obach;Franco Lombardo;Nigel J. Waters

  567
  Citations

• Managing the challenge of chemically reactive metabolites in drug development

  B. Kevin Park;Alan Boobis;Stephen Clarke;Chris E P Goldring

  517
  Citations

• THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/ 1B KNOCKOUT MOUSE MODEL

  Angela Doran;R. Scott Obach;Bill J. Smith;Natilie A. Hosea

  514
  Citations

• The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

  R. Scott Obach;Robert L. Walsky;Karthik Venkatakrishnan;Emily A. Gaman

  500
  Citations

• Aldehyde oxidase: an enzyme of emerging importance in drug discovery.

  David C. Pryde;Deepak Dalvie;Qiyue Hu;Peter Jones

  447
  Citations

• Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine

  Kirk M. Bertelsen;Karthik Venkatakrishnan;Lisa L. von Moltke;R. Scott Obach

  369
  Citations

• Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions.

  Amit S. Kalgutkar;R. Scott Obach;Tristan S. Maurer

  348
  Citations

• Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.

  R. Scott Obach;Amit S. Kalgutkar;John R. Soglia;Sabrina X. Zhao

  294
  Citations

• Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

  Mark E. Flanagan;Joseph A. Abramite;Dennis P. Anderson;Ann Aulabaugh

  293
  Citations

• What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs

  Sarah J. Roffey;R. Scott Obach;Jenny I. Gedge;Dennis A. Smith

  292
  Citations

• Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

  Manthena V S Varma;R Scott Obach;Charles Rotter;Howard R Miller

  290
  Citations

• METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE α4β2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO

  R. Scott Obach;Anne E. Reed-Hagen;Suzanne S. Krueger;Beth J. Obach

  283
  Citations

• Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction

  Odette A. Fahmi;Susan Hurst;David Plowchalk;Jack Cook

  275
  Citations

• SERTRALINE IS METABOLIZED BY MULTIPLE CYTOCHROME P450 ENZYMES, MONOAMINE OXIDASES, AND GLUCURONYL TRANSFERASES IN HUMAN: AN IN VITRO STUDY

  R. Scott Obach;Loretta M. Cox;Larry M. Tremaine

  256
  Citations

• Measurement of michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach

  R. Scott Obach;Anne E. Reed-Hagen

  253
  Citations