World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
15192
World Ranking
10703
National Ranking
4646

Overview

Menghang Xia is affiliated with the National Institutes of Health in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, demonstrated by a substantial body of work.

The scientist's primary fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

They have contributed significantly to several subfields such as:

  • Molecular Biology
  • Pharmacology
  • Computational Theory and Mathematics
  • Infectious Diseases
  • Small Animals

The main topics addressed in their research consist of:

  • Computational Drug Discovery Methods
  • Pharmacogenetics and Drug Metabolism
  • Animal testing and alternatives
  • Estrogen and related hormone effects
  • Cholinesterase and Neurodegenerative Diseases
  • 3D Printing in Biomedical Research
  • Mosquito-borne diseases and control

Frequent collaborators in their research include:

  • Ruili Huang
  • Srilatha Sakamuru
  • Anton Simeonov
  • Tuan Xu
  • Masato Ooka

Menghang Xia has published consistently in several venues, with frequent publications in:

  • Methods in molecular biology
  • Toxicology and Applied Pharmacology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Pharmacology
  • Scientific Reports

Their notable recent papers include:

  • 'Liver three-dimensional cellular models for high-throughput chemical testing' (2023) published in Cell Reports Methods
  • 'Mitochondrial Membrane Potential Assay' (2022) published in Methods in molecular biology
  • 'Biological activity-based modeling identifies antiviral leads against SARS-CoV-2' (2021) published in Nature Biotechnology
  • 'Identification of Compounds for Butyrylcholinesterase Inhibition' (2021) published in SLAS DISCOVERY
  • 'Two-Dimensional Cellular and Three-Dimensional Bio-Printed Skin Models to Screen Topical-Use Compounds for Irritation Potential' (2020) published in Frontiers in Bioengineering and Biotechnology

Xia also authored a book chapter contributing to a publication by Springer Science+Business Media titled High-Throughput Screening Assays in Toxicology in 2022.

Best Publications

  • High-throughput screening assays for the identification of chemical probes

    James Inglese;Ronald L Johnson;Anton Simeonov;Menghang Xia

  • Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

    Miao Xu;Emily M. Lee;Zhexing Wen;Yichen Cheng

  • Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

    Anju Singh;Sreedhar Venkannagari;Kyu H. Oh;Ya Qin Zhang

  • Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead

    William H Goodson;Leroy Lowe;David O Carpenter;Michael Gilbertson

  • Identification of Known Drugs that Act as Inhibitors of NF-κB Signaling and their Mechanism of Action

    Susanne C. Miller;Ruili Huang;Srilatha Sakamuru;Sunita J. Shukla

  • The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

    Sunita J. Shukla;Ruili Huang;Christopher P. Austin;Menghang Xia

  • Compound cytotoxicity profiling using quantitative high-throughput screening.

    Menghang Xia;Ruili Huang;Kristine L. Witt;Noel Southall

  • Assay Guidance Manual [Internet]

    Sarine Markossian;Abigail Grossman;Kyle Brimacombe;Michelle Arkin

  • Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High Throughput Screening Assays for the Estrogen Receptor

    Richard S. Judson;Felicia Maria Magpantay;Vijay Chickarmane;Cymra Haskell

  • 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary.

    Tarang Khare;Shraddha Pai;Karolis Koncevicius;Karolis Koncevicius;Mrinal Pal

  • Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

    Richard Judson;Keith Houck;Matt Martin;Ann M. Richard

  • The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.

    Matias S. Attene-Ramos;Nicole Miller;Ruili Huang;Sam Michael

  • Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization

    Ruili Huang;Menghang Xia;Srilatha Sakamuru;Jinghua Zhao

  • Mitochondrial Membrane Potential Assay.

    Srilatha Sakamuru;Matias S. Attene-Ramos;Menghang Xia

  • Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals.

    Alber Tinka J. Murk;Eddy Rijntjes;Bas J. Blaauboer;Rebecca Clewell

  • Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity

    Richard S. Judson;Matthew T. Martin;David M. Reif;Keith A. Houck

  • Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

    Ruili Huang;Menghang Xia;Ming-Hsuang Cho;Srilatha Sakamuru

  • Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane.

    Menghang Xia;David Leppert;Stephen L. Hauser;Sunil P. Sreedharan

  • Bisphenol A affects androgen receptor function via multiple mechanisms.

    Christina Teng;Bonnie Goodwin;Keith Shockley;Menghang Xia

  • Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential

    Matias S. Attene-Ramos;Ruili Huang;Sam Michael;Kristine L. Witt

Frequent Co-Authors

Ruili Huang
Ruili Huang National Institutes of Health
Christopher P. Austin
Christopher P. Austin National Institutes of Health
Anton Simeonov
Anton Simeonov National Institutes of Health
Raymond R. Tice
Raymond R. Tice National Institutes of Health
Wei Zheng
Wei Zheng National Institutes of Health
James Inglese
James Inglese National Institutes of Health
Hongjun Song
Hongjun Song University of Pennsylvania
Edward J. Goetzl
Edward J. Goetzl University of California, San Francisco
Guo Li Ming
Guo Li Ming University of Pennsylvania
Thomas B. Knudsen
Thomas B. Knudsen Environmental Protection Agency

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