Ivan Rusyn focuses on Internal medicine, Endocrinology, Biochemistry, Liver injury and Kupffer cell. His research investigates the connection with Internal medicine and areas like Apoptosis which intersect with concerns in Uridine. The various areas that he examines in his Liver injury study include Ethanol and CD14.
Ivan Rusyn has researched Kupffer cell in several fields, including Tumor necrosis factor alpha, Glycine, Cytokine, Hepatocyte and Strychnine. His studies in Toxicity integrate themes in fields like Adverse effect, Acetaminophen, Pharmacology, Pharmacogenetics and Genetic association. His work carried out in the field of Gene expression brings together such families of science as Tissue bank and Genotype-Tissue Expression.
His primary areas of study are Internal medicine, Endocrinology, Computational biology, Toxicity and Biochemistry. Ivan Rusyn works mostly in the field of Endocrinology, limiting it down to topics relating to Kupffer cell and, in certain cases, Cytokine, NADPH oxidase and Cell biology. The concepts of his Computational biology study are interwoven with issues in Gene expression, Quantitative structure–activity relationship, Bioinformatics, Quantitative trait locus and Expression quantitative trait loci.
His research ties Regulation of gene expression and Gene expression together. His Expression quantitative trait loci study frequently draws connections to adjacent fields such as Genetic variation. His biological study spans a wide range of topics, including In vitro and Pharmacology.
Ivan Rusyn spends much of his time researching Computational biology, Cancer research, In vitro, In vivo and Internal medicine. His Computational biology research incorporates themes from Hazard, Cardiotoxicity, Expression quantitative trait loci and Regulation of gene expression, Gene. His Expression quantitative trait loci study integrates concerns from other disciplines, such as Quantitative trait locus, Promoter and Transcription factor, Zinc finger.
His work focuses on many connections between Cancer research and other disciplines, such as Epigenetics, that overlap with his field of interest in DNA methylation, DNA damage, Histone, Transcriptome and Carcinogenesis. Ivan Rusyn focuses mostly in the field of In vitro, narrowing it down to matters related to Toxicity and, in some cases, Alcohol, Cytotoxicity, Biochemistry and Lymphoblast. His studies deal with areas such as Endocrinology, Downregulation and upregulation and Peripheral blood mononuclear cell as well as Internal medicine.
His primary areas of investigation include Cancer research, Pharmacology, Gene, Regulation of gene expression and Gene expression. The study incorporates disciplines such as Liver disease, Hepatocyte, Epigenetics and DNA methylation in addition to Cancer research. As a member of one scientific family, Ivan Rusyn mostly works in the field of Pharmacology, focusing on In vitro toxicology and, on occasion, Induced pluripotent stem cell.
His work on Quantitative trait locus, Chromatin, Expression quantitative trait loci and Chromatin remodeling as part of general Gene study is frequently linked to Gene mapping, therefore connecting diverse disciplines of science. His Quantitative trait locus study frequently draws parallels with other fields, such as Computational biology. His Regulation of gene expression research integrates issues from Transcriptome and Gene expression profiling.
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The Genotype-Tissue Expression (GTEx) project
John Lonsdale;Jeffrey Thomas;Mike Salvatore;Rebecca Phillips.
Nature Genetics (2013)
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
Kristin G. Ardlie;David S. Deluca;Ayellet V. Segrè.
Standardizing global gene expression analysis between laboratories and across platforms
Theodore Bammler;Richard P. Beyer;Sanchita Bhattacharya;Gary A. Boorman.
Nature Methods (2005)
NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.
Hiroshi Kono;Ivan I Rusyn;Ming Yin;Erwin Gäbele.
Journal of Clinical Investigation (2000)
In vitro models for liver toxicity testing.
Valerie Y. Soldatow;Edward L. LeCluyse;Linda G. Griffith;Ivan Rusyn.
Toxicology Research (2013)
Role of the Kupffer Cell in Mediating Hepatic Toxicity and Carcinogenesis
Ruth A. Roberts;Patricia E. Ganey;Changqing Ju;Lisa M. Kamendulis.
Toxicological Sciences (2006)
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis.
Martyn T. Smith;Kathryn Z. Guyton;Catherine F. Gibbons;Jason M. Fritz.
Environmental Health Perspectives (2015)
THE ROLE OF KUPFFER CELL OXIDANT PRODUCTION IN EARLY ETHANOL-INDUCED LIVER DISEASE
Michael D. Wheeler;Hiroshi Kono;Ming Yin;Mikio Nakagami.
Free Radical Biology and Medicine (2001)
Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver
Ivan Rusyn;Jeffrey M. Peters;Michael L. Cunningham.
Critical Reviews in Toxicology (2006)
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
Igor P Pogribny;Athena Starlard-Davenport;Volodymyr P Tryndyak;Tao Han.
Laboratory Investigation (2010)
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