What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Internal medicine
Ivan Rusyn focuses on Internal medicine, Endocrinology, Biochemistry, Liver injury and Kupffer cell. His research investigates the connection with Internal medicine and areas like Apoptosis which intersect with concerns in Uridine. The various areas that he examines in his Liver injury study include Ethanol and CD14.
Ivan Rusyn has researched Kupffer cell in several fields, including Tumor necrosis factor alpha, Glycine, Cytokine, Hepatocyte and Strychnine. His studies in Toxicity integrate themes in fields like Adverse effect, Acetaminophen, Pharmacology, Pharmacogenetics and Genetic association. His work carried out in the field of Gene expression brings together such families of science as Tissue bank and Genotype-Tissue Expression.
His most cited work include:
- The Genotype-Tissue Expression (GTEx) project (3925 citations)
- The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans (3083 citations)
- Standardizing global gene expression analysis between laboratories and across platforms (446 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of study are Internal medicine, Endocrinology, Computational biology, Toxicity and Biochemistry. Ivan Rusyn works mostly in the field of Endocrinology, limiting it down to topics relating to Kupffer cell and, in certain cases, Cytokine, NADPH oxidase and Cell biology. The concepts of his Computational biology study are interwoven with issues in Gene expression, Quantitative structure–activity relationship, Bioinformatics, Quantitative trait locus and Expression quantitative trait loci.
His research ties Regulation of gene expression and Gene expression together. His Expression quantitative trait loci study frequently draws connections to adjacent fields such as Genetic variation. His biological study spans a wide range of topics, including In vitro and Pharmacology.
He most often published in these fields:
- Internal medicine (22.03%)
- Endocrinology (18.31%)
- Computational biology (14.58%)
What were the highlights of his more recent work (between 2018-2021)?
- Computational biology (14.58%)
- Cancer research (9.49%)
- In vitro (6.44%)
In recent papers he was focusing on the following fields of study:
Ivan Rusyn spends much of his time researching Computational biology, Cancer research, In vitro, In vivo and Internal medicine. His Computational biology research incorporates themes from Hazard, Cardiotoxicity, Expression quantitative trait loci and Regulation of gene expression, Gene. His Expression quantitative trait loci study integrates concerns from other disciplines, such as Quantitative trait locus, Promoter and Transcription factor, Zinc finger.
His work focuses on many connections between Cancer research and other disciplines, such as Epigenetics, that overlap with his field of interest in DNA methylation, DNA damage, Histone, Transcriptome and Carcinogenesis. Ivan Rusyn focuses mostly in the field of In vitro, narrowing it down to matters related to Toxicity and, in some cases, Alcohol, Cytotoxicity, Biochemistry and Lymphoblast. His studies deal with areas such as Endocrinology, Downregulation and upregulation and Peripheral blood mononuclear cell as well as Internal medicine.
Between 2018 and 2021, his most popular works were:
- Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development (32 citations)
- Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. (30 citations)
- Gene Expression and DNA Methylation Alterations in the Glycine N-Methyltransferase Gene in Diet-Induced Nonalcoholic Fatty Liver Disease-Associated Carcinogenesis. (13 citations)
In his most recent research, the most cited papers focused on:
His primary areas of investigation include Cancer research, Pharmacology, Gene, Regulation of gene expression and Gene expression. The study incorporates disciplines such as Liver disease, Hepatocyte, Epigenetics and DNA methylation in addition to Cancer research. As a member of one scientific family, Ivan Rusyn mostly works in the field of Pharmacology, focusing on In vitro toxicology and, on occasion, Induced pluripotent stem cell.
His work on Quantitative trait locus, Chromatin, Expression quantitative trait loci and Chromatin remodeling as part of general Gene study is frequently linked to Gene mapping, therefore connecting diverse disciplines of science. His Quantitative trait locus study frequently draws parallels with other fields, such as Computational biology. His Regulation of gene expression research integrates issues from Transcriptome and Gene expression profiling.
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