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Biology and Biochemistry

D-Index
87
Citations
24018
World Ranking
2872
National Ranking
1475

Overview

Igor P. Pogribny is affiliated with the National Center for Toxicological Research in the United States. Their research spans several fields including biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, epidemiology, cancer research, physiology, and genetics as prominent subfields.

The main topics covered in their work include liver disease diagnosis and treatment, epigenetics and DNA methylation, adipose tissue and metabolism, diet, metabolism, and disease, cancer, lipids, and metabolism, diet and metabolism studies, and endoplasmic reticulum stress and disease.

Frequent publication venues for Igor P. Pogribny include:

  • UNC Libraries
  • Carcinogenesis
  • The Journal of Nutritional Biochemistry
  • Epigenetics
  • Toxicology and Applied Pharmacology

Notable recent papers authored or co-authored by Igor P. Pogribny are:

  • "Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse Collaborative Cross mouse model", 2020, The FASEB Journal
  • "The DEN and CCl4-Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma", 2021, Current Protocols
  • "Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review", 2021, Mutation Research/Reviews in Mutation Research
  • "Assessment of the effects of organic vs. inorganic arsenic and mercury in Caenorhabditis elegans", 2022, Current Research in Toxicology
  • "Epigenetic effects of low-level sodium arsenite exposure on human liver HepaRG cells", 2020, Archives of Toxicology

Igor P. Pogribny has collaborated frequently with multiple co-authors including Ivan Rusyn, Volodymyr Tryndyak, Frederick A. Beland, Aline de Conti, and Rose Willett.

Best Publications

  • Downregulation of miR‐122 in the rodent and human hepatocellular carcinomas

    Huban Kutay;Shoumei Bai;Jharna Datta;Tasneem Motiwala

  • Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation*

    Ping Yi;Stepan Melnyk;Marta Pogribna;Igor P. Pogribny

  • Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin

    Olga Kovalchuk;Jody Filkowski;James Meservy;Yaroslav Ilnytskyy

  • Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

    Zhoutao Chen;Andrew C. Karaplis;Susan L. Ackerman;Igor P. Pogribny

  • Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome

    S Jill James;Marta Pogribna;Igor P Pogribny;Stepan Melnyk

  • Moderate Folate Depletion Increases Plasma Homocysteine and Decreases Lymphocyte DNA Methylation in Postmenopausal Women

    R A Jacob;D M Gretz;P C Taylor;S J James

  • Elevation in S-Adenosylhomocysteine and DNA Hypomethylation: Potential Epigenetic Mechanism for Homocysteine-Related Pathology

    S. Jill James;Stepan Melnyk;Marta Pogribna;Igor P. Pogribny

  • Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene

    Y I Kim;I P Pogribny;A G Basnakian;J W Miller

  • Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin

    Igor P. Pogribny;Jody N. Filkowski;Volodymyr P. Tryndyak;Andrey Golubov

  • Transgenerational changes in the genome stability and methylation in pathogen-infected plants (Virus-induced plant genome instability)

    Alexander Boyko;Palak Kathiria;Franz J. Zemp;Youli Yao

  • Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.

    I P Pogribny;A G Basnakian;B J Miller;N G Lopatina

  • Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location

    Carole Yauk;Aris Polyzos;Andrea Rowan-Carroll;Christopher M. Somers

  • Intracellular S-Adenosylhomocysteine Concentrations Predict Global DNA Hypomethylation in Tissues of Methyl-Deficient Cystathionine β-Synthase Heterozygous Mice

    Marie A. Caudill;Jennie C. Wang;Stepan Melnyk;Igor P. Pogribny

  • Homocysteine Metabolism in Children with Down Syndrome: In Vitro Modulation

    Marta Pogribna;Stepan Melnyk;Igor Pogribny;Abalo Chango

  • A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands.

    I. Pogribny;Ping Yi;S. J. James;S. J. James

  • Measurement of Plasma and Intracellular S–Adenosylmethionine and S–Adenosylhomocysteine Utilizing Coulometric Electrochemical Detection: Alterations with Plasma Homocysteine and Pyridoxal 5'–Phosphate. Concentrations

    Stepan Melnyk;Marta Pogribna;Igor P. Pogribny;Ping Yi

  • Genome hypermethylation in Pinus silvestris of Chernobyl--a mechanism for radiation adaptation?

    Olga Kovalchuk;Paula Burke;Andrey Arkhipov;Nikolaj Kuchma

  • E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells†‡

    Volodymyr P. Tryndyak;Frederick A. Beland;Igor P. Pogribny

  • Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo.

    I Koturbash;R E Rugo;C A Hendricks;J Loree

  • A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection.

    S Melnyk;M Pogribna;I Pogribny;R J Hine

Frequent Co-Authors

Frederick A. Beland
Frederick A. Beland National Center for Toxicological Research
Ivan Rusyn
Ivan Rusyn Texas A&M University
Stepan Melnyk
Stepan Melnyk University of Arkansas for Medical Sciences
Olga Kovalchuk
Olga Kovalchuk University of Lethbridge
David W. Threadgill
David W. Threadgill Texas A&M University
Daniel R. Doerge
Daniel R. Doerge United States Food and Drug Administration
Thomas J. McDonald
Thomas J. McDonald Texas A&M University
Steven H. Zeisel
Steven H. Zeisel University of North Carolina at Chapel Hill
Igor Kovalchuk
Igor Kovalchuk University of Lethbridge
Rima Rozen
Rima Rozen McGill University

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