2016 - Fellow of the American Association for the Advancement of Science (AAAS)
The scientist’s investigation covers issues in Biochemistry, Lysosome, Mannose 6-phosphate receptor, Mutation and CLN8. His study in Lysosome is interdisciplinary in nature, drawing from both Glycoprotein, Lipid metabolism, Lipid Transport, Transmembrane protein and Cell biology. His work in Mannose 6-phosphate receptor is not limited to one particular discipline; it also encompasses Receptor.
His studies in Mutation integrate themes in fields like Genotype and NPC1. His studies deal with areas such as Binding protein and Pathogenesis as well as NPC1. His work carried out in the field of Mannose brings together such families of science as Molecular biology and Signal peptide.
His primary areas of study are Biochemistry, Lysosome, Mannose, Neuronal ceroid lipofuscinosis and Mannose 6-phosphate receptor. The various areas that he examines in his Biochemistry study include Molecular biology and Cell biology. His Lysosome study incorporates themes from Proteome, Proteomics, Cell fractionation, Subcellular localization and Organelle.
His research in Mannose intersects with topics in Golgi apparatus, Receptor, Peptide sequence, Phosphorylation and Gel electrophoresis. His Neuronal ceroid lipofuscinosis study integrates concerns from other disciplines, such as Lysosomal storage disease and Pharmacology. His NPC1 study combines topics in areas such as Mutation and Niemann–Pick disease.
His primary scientific interests are in Neuronal ceroid lipofuscinosis, Biochemistry, Tripeptidyl peptidase, Lysosome and Cell biology. His Neuronal ceroid lipofuscinosis research is multidisciplinary, incorporating perspectives in Cerebrospinal fluid, Pharmacology and Enzyme replacement therapy. His work in the fields of Biochemistry, such as Tripeptidyl peptidase I and Recombinant DNA, intersects with other areas such as Isobaric labeling.
He works in the field of Lysosome, namely Mannose 6-phosphate receptor. His Mannose 6-phosphate receptor research is multidisciplinary, incorporating elements of Mannose 6-phosphate, Niemann–Pick disease, Fusion protein and Prosaposin. Peter Lobel interconnects Mutation and Phenotype in the investigation of issues within Enzyme.
Peter Lobel focuses on Biochemistry, Tripeptidyl peptidase I, Lysosome, Fusion protein and Mannose 6-phosphate receptor. His Tripeptidyl peptidase I research is classified as research in Neuronal ceroid lipofuscinosis. Peter Lobel has researched Neuronal ceroid lipofuscinosis in several fields, including Spleen, Pharmacokinetics, Nanoparticles for drug delivery to the brain and Recombinant DNA.
Peter Lobel combines subjects such as Golgi apparatus, Endoplasmic reticulum, Proteome and Protein subcellular localization prediction with his study of Lysosome. His Proteome research is multidisciplinary, incorporating perspectives in Lysosomal storage disease, Glycoprotein, Mannose 6-phosphate, Acid phosphatase and Mannose. His studies in Fusion protein integrate themes in fields like mCherry, Green fluorescent protein, Cell biology, Protein folding and Cell fusion.
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Identification of HE1 as the Second Gene of Niemann-Pick C Disease
Saule Naureckiene;David. E. Sleat;David. E. Sleat;Henry Lackland;Anthony Fensom.
Mannose 6-Phosphate Receptors and Lysosomal Enzyme Targeting
N. M. Dahms;P. Lobel;Stuart Kornfeld.
Journal of Biological Chemistry (1989)
Association of Mutations in a Lysosomal Protein with Classical Late-Infantile Neuronal Ceroid Lipofuscinosis
David E. Sleat;David E. Sleat;Robert J. Donnelly;Henry Lackland;Henry Lackland;Chang Gong Liu.
Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport
David E. Sleat;Jennifer A. Wiseman;Mukarram El-Banna;Sandy M. Price.
Proceedings of the National Academy of Sciences of the United States of America (2004)
STRUCTURE OF A CHOLESTEROL-BINDING PROTEIN DEFICIENT IN NIEMANN-PICK TYPE C2 DISEASE
Natalia Friedland;Heng-Ling Liou;Peter Lobel;Ann M. Stock.
Proceedings of the National Academy of Sciences of the United States of America (2003)
Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis.
Peter Lobel;Karen Fujimoto;Richard D. Ye;Gareth Griffiths.
Proteomics of the Lysosome
Torben Lübke;Peter Lobel;Peter Lobel;David E. Sleat;David E. Sleat.
Biochimica et Biophysica Acta (2009)
A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration
Jaana Tyynelä;Istvan Sohar;David E. Sleat;Rosalie M. Gin.
The EMBO Journal (2000)
Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor.
P. Lobel;N. M. Dahms;Stuart Kornfeld.
Journal of Biological Chemistry (1988)
Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils.
Amitabha Majumdar;Dana Cruz;Nikiya Asamoah;Adina Buxbaum.
Molecular Biology of the Cell (2007)
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