What is she best known for?
The fields of study she is best known for:
- Enzyme
- Gene
- Internal medicine
Her primary scientific interests are in Cell biology, Biochemistry, Substrate reduction therapy, Glycosphingolipid and Sphingolipid.
She has included themes like CD1D, Lysosome and Autophagy in her Cell biology study.
Her Substrate reduction therapy research is multidisciplinary, incorporating elements of GM2 gangliosidoses, Endocrinology and Miglustat.
Her Glycosphingolipid research is multidisciplinary, relying on both High-performance liquid chromatography, Mutant, Pharmacology and In vivo.
Her Sphingolipid study incorporates themes from Lysosomal storage disease, Endocytic cycle and Sphingosine.
Her biological study spans a wide range of topics, including Gastroenterology and Surgery.
Her most cited work include:
- bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. (1105 citations)
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease (796 citations)
- Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis (640 citations)
What are the main themes of her work throughout her whole career to date?
The scientist’s investigation covers issues in Biochemistry, Cell biology, Internal medicine, Immunology and NPC1.
Her Cell biology study which covers Lysosome that intersects with Neurodegeneration.
Her work in Internal medicine addresses subjects such as Endocrinology, which are connected to disciplines such as Ganglioside.
Her Immunology research focuses on subjects like Sandhoff disease, which are linked to Gangliosidosis and Ganglioside GM2.
Her NPC1 research integrates issues from Lysosomal storage disease and Niemann–Pick disease, type C.
Frances M. Platt has researched Glycosphingolipid in several fields, including Substrate reduction therapy and In vivo.
She most often published in these fields:
- Biochemistry (23.62%)
- Cell biology (23.31%)
- Internal medicine (15.95%)
What were the highlights of her more recent work (between 2017-2021)?
- NPC1 (13.50%)
- Cell biology (23.31%)
- Niemann–Pick disease, type C (11.04%)
In recent papers she was focusing on the following fields of study:
Frances M. Platt spends much of her time researching NPC1, Cell biology, Niemann–Pick disease, type C, Internal medicine and Lysosome.
The various areas that Frances M. Platt examines in her NPC1 study include Vesicle, Sphingolipid, Biophysics, Mutant and Exocytosis.
Her Cell biology research focuses on Endosome in particular.
The concepts of her Niemann–Pick disease, type C study are interwoven with issues in Adult patients, Miglustat and Clinical severity.
Her Internal medicine research includes elements of Experimental therapy and Endocrinology.
Her Lysosome research incorporates elements of Juvenile, Dystrophy, Neurodegeneration, Neuron death and Late endosome.
Between 2017 and 2021, her most popular works were:
- Lysosomal storage diseases. (177 citations)
- Emptying the stores: lysosomal diseases and therapeutic strategies (88 citations)
- NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress (57 citations)
In her most recent research, the most cited papers focused on:
- Gene
- Enzyme
- Internal medicine
Her scientific interests lie mostly in Neurodegeneration, Lysosome, Genetic enhancement, NPC1 and Cell biology.
Frances M. Platt works mostly in the field of Neurodegeneration, limiting it down to topics relating to Glucocerebrosidase and, in certain cases, Immunology, Cre recombinase and Enzyme replacement therapy, as a part of the same area of interest.
Her Lysosome research is multidisciplinary, relying on both Endocrinology, Internal medicine and Parkinson's disease.
Her NPC1 study incorporates themes from Miglustat and Niemann–Pick disease.
Frances M. Platt has included themes like Disease Pathway, Substrate reduction therapy, Transgene and Niemann–Pick disease, type C in her Niemann–Pick disease study.
Her study in the field of Endosome is also linked to topics like TLR9.
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