World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
28112
World Ranking
2445
National Ranking
24

Overview

Anthony H. Futerman is affiliated with the Weizmann Institute of Science in Israel. Their research prominently spans multiple areas intersecting biochemistry, genetics, molecular biology, and medicine, with significant contributions in subfields such as molecular biology, physiology, cell biology, surgery, and immunology.

Their main areas of study focus on lipid biology, including sphingolipid metabolism and signaling, lysosomal storage disorders, lipid membrane structure and behavior, as well as broader topics involving cellular transport and secretion. Additional topics include cholesterol and lipid metabolism, lipid metabolism and biosynthesis, and mechanisms and treatments related to Parkinson's disease.

Frequent publication venues where Futerman has contributed include:

  • Journal of Biological Chemistry
  • IUPHAR/BPS Guide to Pharmacology CITE
  • Journal of Lipid Research
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • Inference International Review of Science

Their recent papers feature a focus on lipid metabolism and neurological disorders. Notable publications include:

  • "GBA mutations, glucosylceramide and Parkinson's disease" (2021, Current Opinion in Neurobiology)
  • "The fine-tuning of cell membrane lipid bilayers accentuates their compositional complexity" (2021, BioEssays)
  • "Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson's Disease" (2020, International Journal of Molecular Sciences)
  • "Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases" (2023, Nature Communications)
  • "16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis" (2021, iScience)

Frequent co-authors collaborating extensively with Futerman include:

  • Tamir Dingjan
  • Shani Blumenreich
  • Iris D. Zelnik
  • Jiyoon L. Kim
  • Shifra Ben-Dor

Best Publications

  • The cell biology of lysosomal storage disorders.

    Anthony H. Futerman;Gerrit van Meer

  • The complex life of simple sphingolipids

    Anthony H Futerman;Yusuf A Hannun

  • Mammalian ceramide synthases.

    Michal Levy;Anthony H. Futerman

  • Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases

    Ye Ryung Kim;Eun Ji Lee;Eun Ji Lee;Kyong Oh Shin;Min Hee Kim

  • When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis.

    Yael Pewzner-Jung;Shifra Ben-Dor;Anthony H. Futerman

  • Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate.

    Elad L. Laviad;Lee Albee;Irene Pankova-Kholmyansky;Sharon Epstein

  • Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus.

    A H Futerman;B Stieger;A L Hubbard;R E Pagano

  • Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system

    Yoseph Shaaltiel;Daniel Bartfeld;Sharon Hashmueli;Gideon Baum

  • CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

    Suryaprakash Raichur;Siew Tein Wang;Puck Wee Chan;Ying Li

  • Common and uncommon pathogenic cascades in lysosomal storage diseases.

    Einat B. Vitner;Frances M. Platt;Anthony H. Futerman

  • The ins and outs of sphingolipid synthesis.

    Anthony H. Futerman;Howard Riezman

  • The metabolism and function of sphingolipids and glycosphingolipids.

    S. Lahiri;A. H. Futerman

  • Two Mammalian Longevity Assurance Gene (LAG1) Family Members, trh1 and trh4, Regulate Dihydroceramide Synthesis Using Different Fatty Acyl-CoA Donors

    Christian Riebeling;Jeremy C. Allegood;Elaine Wang;Alfred H. Merrill

  • Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver

    A H Futerman;R E Pagano

  • A Dynamic Interface between Vacuoles and Mitochondria in Yeast

    Yael Elbaz-Alon;Eden Rosenfeld-Gur;Vera Shinder;Anthony H. Futerman

  • Gaucher disease: pathological mechanisms and modern management.

    Marina Jmoudiak;Anthony H. Futerman

  • Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells.

    Krishnan Venkataraman;Christian Riebeling;Jacques Bodennec;Howard Riezman

  • X‐ray structure of human acid‐β‐glucosidase, the defective enzyme in Gaucher disease

    Hay Dvir;Michal Harel;Andrew A McCarthy;Lilly Toker

  • Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins

    Martin G Low;Michael A.J Ferguson;Michael A.J Ferguson;Anthony H Futerman;Israel Silman

  • A Critical Role for Ceramide Synthase 2 in Liver Homeostasis II. INSIGHTS INTO MOLECULAR CHANGES LEADING TO HEPATOPATHY

    Yael Pewzner-Jung;Ori Brenner;Svantje Braun;Elad L. Laviad

Frequent Co-Authors

Israel Silman
Israel Silman Weizmann Institute of Science
Alfred H. Merrill
Alfred H. Merrill Georgia Institute of Technology
Joel L. Sussman
Joel L. Sussman Weizmann Institute of Science
Manuel Prieto
Manuel Prieto Instituto Superior Técnico
Erich Gulbins
Erich Gulbins University of Duisburg-Essen
Maya Schuldiner
Maya Schuldiner Weizmann Institute of Science
Frances M. Platt
Frances M. Platt University of Oxford
Howard Riezman
Howard Riezman University of Geneva
Edward H. Schuchman
Edward H. Schuchman Icahn School of Medicine at Mount Sinai
Karl S. Lang
Karl S. Lang University of Duisburg-Essen

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