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Biology and Biochemistry

D-Index
70
Citations
36070
World Ranking
6841
National Ranking
3157

Overview

Besim Ogretmen is affiliated with the Medical University of South Carolina in the United States and conducts research primarily in the fields of biochemistry, genetics, and molecular biology, with a significant focus on medicine. Their scholarly work spans multiple subfields including molecular biology, immunology, cancer research, epidemiology, and cell biology.

The scientist's research topics concentrate on sphingolipid metabolism and signaling, with additional focus on endoplasmic reticulum stress and disease, autophagy in disease and therapy, cancer, lipids, and metabolism, immune cells in cancer, immune cell function and interaction, as well as lipid metabolism and biosynthesis.

Frequent publication venues for Besim Ogretmen include Cancer Research, Cancers, Cell Reports, Aging Cell, and the Journal of Biological Chemistry. These venues reflect the interdisciplinary nature of their research, bridging molecular biology and clinical applications.

Some of the more recent publications authored or co-authored by the scientist are:

  • "Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response," 2021, Cell Reports
  • "The Role of Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy," 2021, Cancers
  • "Targeting Sphingolipid Metabolism as a Therapeutic Strategy in Cancer Treatment," 2022, Cancers
  • "Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients," 2021, Scientific Reports
  • "The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020," 2020, Cancers

Besim Ogretmen collaborates frequently with several researchers, including Shikhar Mehrotra, Mohamed Faisal Kassir, Natalia V. Oleinik, Alhaji H. Janneh, and Paramita Chakraborty. These collaborations have contributed to a broad spectrum of investigations related to cancer biology, lipid metabolism, and immune cell function.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Biologically active sphingolipids in cancer pathogenesis and treatment.

    Besim Ogretmen;Yusuf A. Hannun

  • Sphingolipid metabolism in cancer signalling and therapy

    Besim Ogretmen

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

    R David Sentelle;Can E Senkal;Wenhui Jiang;Suriyan Ponnusamy

  • De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells DEPENDENCE ON PROTEIN PHOSPHATASE-1

    Charles E. Chalfant;Kristin Rathman;Ryan L. Pinkerman;Rachel E. Wood

  • Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.

    Suriyan Ponnusamy;Marisa Meyers-Needham;Can E Senkal;Sahar A Saddoughi

  • Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

    Can E. Senkal;Suriyan Ponnusamy;Jacek Bielawski;Yusuf A. Hannun

  • Roles of bioactive sphingolipids in cancer biology and therapeutics.

    Sahar A. Saddoughi;Pengfei Song;Besim Ogretmen

  • Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.

    Sahar A. Saddoughi;Salih Gencer;Yuri K. Peterson;Katherine E. Ward

  • Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas *

    Serap Koybasi;Can E. Senkal;Kamala Sundararaj;Stefka Spassieva

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Biochemical Mechanisms of the Generation of Endogenous Long Chain Ceramide in Response to Exogenous Short Chain Ceramide in the A549 Human Lung Adenocarcinoma Cell Line ROLE FOR ENDOGENOUS CERAMIDE IN MEDIATING THE ACTION OF EXOGENOUS CERAMIDE

    Besim Ogretmen;Benjamin J. Pettus;Michael J. Rossi;Rachel Wood

  • Alterations of Ceramide/Sphingosine 1-Phosphate Rheostat Involved in the Regulation of Resistance to Imatinib-induced Apoptosis in K562 Human Chronic Myeloid Leukemia Cells

    Yusuf Baran;Arelis Salas;Can E. Senkal;Ufuk Gunduz

  • CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

    Shilpak Chatterjee;Anusara Daenthanasanmak;Paramita Chakraborty;Megan W. Wyatt

  • PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

    Paolo Neviani;Jason G. Harb;Joshua J. Oaks;Ramasamy Santhanam

  • Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue.

    Korey R. Johnson;Kristy Y. Johnson;Heather G. Crellin;Besim Ogretmen

  • Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

    Archana Mukhopadhyay;Sahar A. Saddoughi;Pengfei Song;Iyad Sultan;Iyad Sultan

  • Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells

    Jacqueline M. Kraveka;Li Li;Zdzislaw M. Szulc;Jacek Bielawski

Frequent Co-Authors

Lina M. Obeid
Lina M. Obeid Stony Brook University
Yusuf A. Hannun
Yusuf A. Hannun Stony Brook University
Jacek Bielawski
Jacek Bielawski Medical University of South Carolina
Paul Dent
Paul Dent Virginia Commonwealth University
Charles D. Smith
Charles D. Smith University of Kentucky
Steven Grant
Steven Grant Virginia Commonwealth University
Paul B. Fisher
Paul B. Fisher Virginia Commonwealth University
Xue-Zhong Yu
Xue-Zhong Yu Medical College of Wisconsin
Robert V. Stahelin
Robert V. Stahelin Purdue University West Lafayette
Sergio Lavandero
Sergio Lavandero University of Chile

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