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D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
11772
World Ranking
13834
National Ranking
5851

Overview

Charles E. Chalfant is affiliated with Virginia Commonwealth University in the United States. Their research primarily covers the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a total of 68 publications in the former and 60 in the latter. Among subfields, they have contributed extensively to Molecular Biology, Genetics, Physiology, Surgery, and Endocrinology, Diabetes and Metabolism.

Their main research topics include Sphingolipid Metabolism and Signaling, Pancreatic function and diabetes, Diabetes and associated disorders, Acute Myeloid Leukemia Research, Lipid Membrane Structure and Behavior, Cancer-related molecular mechanisms research, and RNA modifications and cancer.

Chalfant has published frequently in several venues, with notable repeat appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Diabetes
  • Molecular Neurobiology
  • Journal of Lipid Research
  • Science Signaling

Among recent research papers, the following are highlighted for their topics and venues:

  • Ceramide Kinase Inhibition Drives Ferroptosis and Sensitivity to Cisplatin in Mutant KRAS Lung Cancer by Dysregulating VDAC-Mediated Mitochondria Function, 2022, Molecular Cancer Research
  • Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death, 2020, Progress in Lipid Research
  • Sphingosine-1-phosphate interactions in the spleen and heart reflect extent of cardiac repair in mice and failing human hearts, 2021, American Journal of Physiology-Heart and Circulatory Physiology
  • Lipid mediators and biomarkers associated with type 1 diabetes development, 2020, JCI Insight
  • Meibum sphingolipid composition is altered in individuals with meibomian gland dysfunction-a side by side comparison of Meibum and Tear Sphingolipids, 2021, The Ocular Surface

Collaborations have been consistent with several researchers, including:

  • Daniel Stephenson
  • Nawajes Mandal
  • H. Patrick MacKnight
  • Sasanka Ramanadham
  • Xiujie Xie

Best Publications

  • Ceramide in apoptosis: an overview and current perspectives.

    Benjamin J. Pettus;Charles E. Chalfant;Yusuf A. Hannun

  • Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

    Charles E. Chalfant;Charles E. Chalfant;Sarah Spiegel

  • Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid.

    Charles E. Chalfant;Katsuya Kishikawa;Marc C. Mumby;Craig Kamibayashi

  • Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2

    Benjamin J. Pettus;Alicja Bielawska;Preeti Subramanian;Dayanjan S. Wijesinghe

  • De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells DEPENDENCE ON PROTEIN PHOSPHATASE-1

    Charles E. Chalfant;Kristin Rathman;Ryan L. Pinkerman;Rachel E. Wood

  • The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-α

    Benjamin J. Pettus;Jacek Bielawski;Anna M. Porcelli;Davis L. Reames

  • The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x

    Maria Paola Paronetto;Tilman Achsel;Autumn Massiello;Autumn Massiello;Charles E. Chalfant;Charles E. Chalfant

  • Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.

    Benjamin J. Pettus;Alicja Bielawska;Sarah Spiegel;Patrick Roddy

  • Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

    Dhirendra K. Simanshu;Ravi Kanth Kamlekar;Dayanjan S. Wijesinghe;Xianqiong Zou

  • Mechanism of Apoptosis Induced by the Inhibition of Fatty Acid Synthase in Breast Cancer Cells

    Sucharita Bandyopadhyay;Rui Zhan;Ying Wang;Sudha K. Pai

  • Hypertension is associated with marked alterations in sphingolipid biology: a potential role for ceramide

    Léon J. A. Spijkers;Rob F. P. van den Akker;Ben J. A. Janssen;Jacques J. Debets

  • The structural requirements for ceramide activation of serine-threonine protein phosphatases

    Charles E. Chalfant;Charles E. Chalfant;Zdzislaw Szulc;Patrick Roddy;Alicja Bielawska

  • FAS Activation Induces Dephosphorylation of SR Proteins DEPENDENCE ON THE DE NOVO GENERATION OF CERAMIDE AND ACTIVATION OF PROTEIN PHOSPHATASE 1

    Charles E. Chalfant;Besim Ogretmen;Sehamuddin Galadari;Bart Jan Kroesen

  • Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension

    Jose Gomez-Arroyo;Shiro Mizuno;Karol Szczepanek;Benjamin Van Tassell

  • The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.

    Shawn G. Payne;Carole A. Oskeritzian;Rachael Griffiths;Preeti Subramanian

  • Sphingolipids in Inflammation: Roles and Implications

    B. J. Pettus;C. E. Chalfant;Y. A. Hannun

  • The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate.

    Benjamin James Pettus;Kazuyuki Kitatani;Charles E. Chalfant;Tarek A. Taha

  • Alternative Splicing of Caspase 9 Is Modulated by the Phosphoinositide 3-Kinase/Akt Pathway via Phosphorylation of SRp30a

    Jacqueline C. Shultz;Rachel W. Goehe;D. Shanaka Wijesinghe;Charuta Murudkar

  • Ceramide 1-Phosphate Acts as a Positive Allosteric Activator of Group IVA Cytosolic Phospholipase A2α and Enhances the Interaction of the Enzyme with Phosphatidylcholine

    Preeti Subramanian;Robert V. Stahelin;Zdzislaw Szulc;Alicja Bielawska

  • Ceramide-1-phosphate binds group IVA cytosolic phospholipase a2 via a novel site in the C2 domain.

    Robert V. Stahelin;Preeti Subramanian;Mohsin Vora;Wonhwa Cho

Frequent Co-Authors

Yusuf A. Hannun
Yusuf A. Hannun Stony Brook University
Robert V. Stahelin
Robert V. Stahelin Purdue University West Lafayette
Alicja Bielawska
Alicja Bielawska Medical University of South Carolina
Lina M. Obeid
Lina M. Obeid Stony Brook University
Sasanka Ramanadham
Sasanka Ramanadham University of Alabama at Birmingham
Sarah Spiegel
Sarah Spiegel Virginia Commonwealth University
Jeremy C. Allegood
Jeremy C. Allegood Virginia Commonwealth University
Rhoderick E. Brown
Rhoderick E. Brown University of Minnesota
John J. Ryan
John J. Ryan Virginia Commonwealth University
Wonhwa Cho
Wonhwa Cho University of Illinois at Chicago

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