Charles E. Chalfant spends much of his time researching Ceramide, Biochemistry, Lipid signaling, Cell biology and Ceramide kinase. He combines subjects such as Tumor necrosis factor alpha, Cancer research, Enzyme activator, Sphingosine-1-phosphate and Protein phosphatase 1 with his study of Ceramide. His research investigates the link between Protein phosphatase 1 and topics such as Molecular biology that cross with problems in Alternative splicing, Tyrosine phosphorylation, Heterogeneous ribonucleoprotein particle and Phosphorylation.
His specific area of interest is Biochemistry, where he studies Protein phosphatase 2. Charles E. Chalfant interconnects Phospholipase A2 and Arachidonic acid in the investigation of issues within Ceramide kinase. His Arachidonic acid research is multidisciplinary, incorporating perspectives in Calcium, Cytokine and Cytosol.
Charles E. Chalfant focuses on Biochemistry, Ceramide, Ceramide kinase, Cell biology and Lipid signaling. The Phospholipase A2, Cytosol, In vitro and Vesicle research Charles E. Chalfant does as part of his general Biochemistry study is frequently linked to other disciplines of science, such as Dissociation constant, therefore creating a link between diverse domains of science. His Ceramide study combines topics in areas such as Tumor necrosis factor alpha, Phosphatase, Protein phosphatase 1, Sphingolipid and Molecular biology.
The Ceramide kinase study combines topics in areas such as Ceramide transport, Calcium, Lipidomics and Eicosanoid. His research integrates issues of Apoptosis, Arachidonic acid, Phospholipase A and Alternative splicing in his study of Cell biology. The study incorporates disciplines such as Serine, Sphingosine-1-phosphate, Function, Proinflammatory cytokine and Macrophage in addition to Lipid signaling.
His primary scientific interests are in Immunology, Inflammation, Sphingolipid, Ceramide and Endocrinology. His Sphingolipid research incorporates themes from Aspirin, Hydroxyeicosatetraenoic acid and Prostacyclin. His Ceramide research incorporates elements of Wound healing, Phospholipase A2 and Sphingomyelin.
His Nod research is multidisciplinary, incorporating elements of Arachidonic acid, Lipid signaling and Immune system. Charles E. Chalfant studied NOD mice and Eicosanoid that intersect with Cell biology. His Cell biology research is multidisciplinary, relying on both Proinflammatory cytokine and Molecular biology.
His scientific interests lie mostly in Pharmacology, Inflammation, Molecular biology, NF-κB and Caspase. His Pharmacology study combines topics from a wide range of disciplines, such as Glycolysis, Lipopolysaccharide, Cytokine and Sepsis. He has included themes like Mast cell, Serine C-palmitoyltransferase and Glucose uptake in his Inflammation study.
Charles E. Chalfant combines Molecular biology and Ubiquitin ligase in his research. His NF-κB study integrates concerns from other disciplines, such as Cancer research and Cell growth.
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Ceramide in apoptosis: an overview and current perspectives.
Benjamin J. Pettus;Charles E. Chalfant;Yusuf A. Hannun.
Biochimica et Biophysica Acta (2002)
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling
Charles E. Chalfant;Charles E. Chalfant;Sarah Spiegel.
Journal of Cell Science (2005)
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid.
Charles E. Chalfant;Katsuya Kishikawa;Marc C. Mumby;Craig Kamibayashi.
Journal of Biological Chemistry (1999)
De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells DEPENDENCE ON PROTEIN PHOSPHATASE-1
Charles E. Chalfant;Kristin Rathman;Ryan L. Pinkerman;Rachel E. Wood.
Journal of Biological Chemistry (2002)
Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2
Benjamin J. Pettus;Alicja Bielawska;Preeti Subramanian;Dayanjan S. Wijesinghe.
Journal of Biological Chemistry (2004)
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-α
Benjamin J. Pettus;Jacek Bielawski;Anna M. Porcelli;Davis L. Reames.
The FASEB Journal (2003)
The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
Maria Paola Paronetto;Tilman Achsel;Autumn Massiello;Autumn Massiello;Charles E. Chalfant;Charles E. Chalfant.
Journal of Cell Biology (2007)
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.
Benjamin J. Pettus;Alicja Bielawska;Sarah Spiegel;Patrick Roddy.
Journal of Biological Chemistry (2003)
The structural requirements for ceramide activation of serine-threonine protein phosphatases
Charles E. Chalfant;Charles E. Chalfant;Zdzislaw Szulc;Patrick Roddy;Alicja Bielawska.
Journal of Lipid Research (2004)
FAS Activation Induces Dephosphorylation of SR Proteins DEPENDENCE ON THE DE NOVO GENERATION OF CERAMIDE AND ACTIVATION OF PROTEIN PHOSPHATASE 1
Charles E. Chalfant;Besim Ogretmen;Sehamuddin Galadari;Bart Jan Kroesen.
Journal of Biological Chemistry (2001)
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