World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
16141
World Ranking
4656
National Ranking
2256

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Wonhwa Cho is affiliated with the University of Illinois at Chicago in the United States. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, pharmacology, surgery, oncology, and cancer research. The primary areas of study reflect significant emphasis on cholesterol and lipid metabolism, cancer-related lipid processes, pharmacological effects of natural compounds, inflammatory mediators and NSAID effects, cellular transport and secretion, lipid membrane structure and behavior, and retinal development and disorders.

Their publication record includes research articles in a range of scientific journals and venues such as Methods in Molecular Biology, bioRxiv (Cold Spring Harbor Laboratory), Science, The FASEB Journal, and the Journal of Lipid Research. Some of the recent papers authored or co-authored by Cho include:

  • Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly, 2023, Science
  • ORP2, a cholesterol transporter, regulates angiogenic signaling in endothelial cells, 2020, The FASEB Journal
  • Development of a novel spatiotemporal depletion system for cellular cholesterol, 2022, Journal of Lipid Research
  • An In Situ Fluorescence Assay for Cholesterol Transporter Activity of the Patched, 2021, Methods in Molecular Biology
  • Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: a novel path to cancer prevention, 2024, bioRxiv (Cold Spring Harbor Laboratory)

Throughout their career, Cho has frequently collaborated with colleagues including Ashutosh Sharma, Kyli Berkley, Jiachen Sun, Arthur Ralko, and Indira Singaram. These collaborations have contributed to multiple publications across various venues.

Cho's work consistently involves investigations into biochemical processes related to lipid metabolism and transport within cellular systems, often focusing on the pharmacological and molecular biology aspects related to disease mechanisms such as cancer and inflammation.

Among honors received, Cho was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2018, recognizing their contributions to scientific research.

Best Publications

  • Membrane-protein interactions in cell signaling and membrane trafficking.

    Wo nhwa Cho;Robert V. Stahelin

  • Membrane-binding and activation mechanism of PTEN.

    Sudipto Das;Jack E. Dixon;Wonhwa Cho

  • Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

    Dimitrios Karathanassis;Robert V. Stahelin;Jerónimo Bravo;Olga Perisic

  • Membrane binding and subcellular targeting of C2 domains.

    Wonhwa Cho;Robert V. Stahelin

  • A new class of phospholipases A2 with lysine in place of aspartate 49. Functional consequences for calcium and substrate binding.

    J. M. Maraganore;G. Merutka;Wonhwa Cho;W. Welches

  • Membrane targeting by C1 and C2 domains.

    Wonhwa Cho

  • Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol.

    Shu Lin Liu;Ren Sheng;Jae Hun Jung;Li Wang

  • Contrasting Membrane Interaction Mechanisms of AP180 N-terminal Homology (ANTH) and Epsin N-terminal Homology (ENTH) Domains*

    Robert V. Stahelin;Fei Long;Brian J. Peter;Diana Murray

  • Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase.

    Shilpa Kulkarni;Sudipto Das;Colin D. Funk;Diana Murray

  • The antibacterial properties of secreted phospholipases A2: a major physiological role for the group IIA enzyme that depends on the very high pI of the enzyme to allow penetration of the bacterial cell wall.

    Stephen A. Beers;Andrew G. Buckland;Rao S. Koduri;Wonhwa Cho

  • Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

    Arun K Ghosh;John F Kincaid;Wonhwa Cho;D.Eric Walters

  • Roles of Trp31 in High Membrane Binding and Proinflammatory Activity of Human Group V Phospholipase A2

    Sang Kyou Han;Kwang Pyo Kim;Rao Koduri;Lenka Bittova

  • Interplay of C1 and C2 Domains of Protein Kinase C-α in Its Membrane Binding and Activation

    Martina Medkova;Wonhwa Cho

  • Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.

    Yunxiao Zhang;David P. Bulkley;Yao Xin;Kelsey J. Roberts

  • Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro.

    Bruno Lomonte;Yamileth Angulo;Stefano Rufini;Wonhwa Cho

  • Phosphatidylinositol 3-Phosphate Induces the Membrane Penetration of the FYVE Domains of Vps27p and Hrs

    Robert V. Stahelin;Fei Long;Karthikeyan Diraviyam;Karol S. Bruzik

  • Raft-based interactions of gangliosides with a GPI-anchored receptor

    Naoko Komura;Naoko Komura;Kenichi G N Suzuki;Kenichi G N Suzuki;Hiromune Ando;Hiromune Ando;Miku Konishi;Miku Konishi

  • A Structure-Function Study of the C2 Domain of Cytosolic Phospholipase A2: IDENTIFICATION OF ESSENTIAL CALCIUM LIGANDS AND HYDROPHOBIC MEMBRANE BINDING RESIDUES

    Lenka Bittova;Marius Sumandea;Wonhwa Cho

  • Differential roles of ionic, aliphatic, and aromatic residues in membrane-protein interactions: a surface plasmon resonance study on phospholipases A2.

    Robert V. Stahelin;Wonhwa Cho

  • Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox.

    Robert V. Stahelin;Aura Burian;Karol S. Bruzik;Diana Murray

Frequent Co-Authors

Robert V. Stahelin
Robert V. Stahelin Purdue University West Lafayette
Kwang Pyo Kim
Kwang Pyo Kim Kyung Hee University
Sung Ho Ryu
Sung Ho Ryu Pohang University of Science and Technology
Michael H. Gelb
Michael H. Gelb University of Washington
Michelle A. Digman
Michelle A. Digman University of California, Irvine
Charles E. Chalfant
Charles E. Chalfant Virginia Commonwealth University
Yifan Cheng
Yifan Cheng University of California, San Francisco
Barry Honig
Barry Honig Columbia University
Roger L. Williams
Roger L. Williams University of Cambridge
Philip A. Beachy
Philip A. Beachy Stanford University

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