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Biology and Biochemistry

D-Index
95
Citations
47309
World Ranking
1866
National Ranking
119

Overview

Roger L. Williams is affiliated with the University of Cambridge in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology with 54 publications, and Medicine with 46 publications. The work covers key subfields including Molecular Biology, Cell Biology, Epidemiology, Genetics, and Surgery.

The scientist's research focuses on several main topics, which include:

  • PI3K/AKT/mTOR signaling in cancer
  • Cellular transport and secretion
  • Chronic Lymphocytic Leukemia Research
  • Liver Disease Diagnosis and Treatment
  • Protein Kinase Regulation and GTPase Signaling
  • Lipid Membrane Structure and Behavior
  • Immunodeficiency and Autoimmune Disorders

Williams has contributed to multiple recent papers in various scientific journals. Notable publications include:

  • "A small-molecule PI3Kα activator for cardioprotection and neuroregeneration," 2023, published in Nature
  • "Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes," 2021, published in Nature Communications
  • "PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation," 2021, published in Science
  • "Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes," 2020, published in eLife
  • "Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils," 2020, published in Science Signaling

Their research has appeared frequently in journals such as:

  • Journal of Hepatology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Science
  • Biophysical Journal

Williams often collaborates with several recurring co-authors, including:

  • Olga Perišić (13 joint publications)
  • Glenn R. Masson (9 joint publications)
  • Shilpa Chokshi (9 joint publications)
  • Yohei Ohashi (6 joint publications)
  • Madhanagopal Anandapadamanaban (6 joint publications)

In addition to research articles, Roger L. Williams has authored books published by Penn State University Press, with titles such as "Frederick Watts and the Founding of Penn State" published in 2021.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

    A Jacobo-Molina;J Ding;R G Nanni;A D Clark

  • Structural Determinants of Phosphoinositide 3-kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

    Edward H. Walker;Michael E. Pacold;Olga Perisic;Len Stephens

  • A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

    Zachary A Knight;Beatriz Gonzalez;Morri E Feldman;Eli R Zunder

  • The emerging shape of the ESCRT machinery

    Roger L. Williams;Sylvie Urbé

  • Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

    Michael E. Pacold;Sabine Suire;Olga Perisic;Samuel Lara-Gonzalez

  • Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.

    Lars-Oliver Essen;Olga Perisic;Robert Cheung;Matilda Katan

  • Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

    Ivan Angulo;Oscar Vadas;Fabien Garçon;Edward Banham-Hall

  • Structural insights into phosphoinositide 3-kinase catalysis and signalling.

    Edward H. Walker;Olga Perisic;Christian Ried;Len Stephens

  • Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

    Beth Apsel;Jimmy A. Blair;Beatriz Z. Gonzalez;Beatriz Z. Gonzalez;Tamim M. Nazif

  • Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit.

    Nabil Miled;Ying Yan;Wai Ching Hon;Olga Perisic

  • A Role for the ESCRT System in Cell Division in Archaea

    Rachel Y. Samson;Takayuki Obita;Stefan M. Freund;Roger L. Williams

  • Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

    Dimitrios Karathanassis;Robert V. Stahelin;Jerónimo Bravo;Olga Perisic

  • Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2

    Olga Perisic;Sun Fong;Denise E. Lynch;Mark Bycroft

  • Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

    Simon Miller;Brandon Tavshanjian;Arkadiusz Oleksy;Olga Perisic

  • Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4.

    Takayuki Obita;Suraj Saksena;Sara Ghazi-Tabatabai;David J. Gill

  • The p110[delta] structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

    Alex Berndt;Simon Miller;Olusegun Williams;Daniel D Le

  • The Crystal Structure of the Px Domain from P40Phox Bound to Phosphatidylinositol 3-Phosphate

    Jerónimo Bravo;Dimitrios Karathanassis;Christine M Pacold;Michael E Pacold

  • TREATMENT OF MULTIPLE-HORMONE-PRODUCING MALIGNANT ISLET-CELL TUMOUR WITH STREPTOZOTOCIN

    I.M. Murray-Lyon;A.L.W.F. Eddleston;Roger Williams;Michael Brown

Frequent Co-Authors

Olga Perisic
Olga Perisic MRC Laboratory of Molecular Biology
Len R. Stephens
Len R. Stephens Babraham Institute
Christopher M. Johnson
Christopher M. Johnson MRC Laboratory of Molecular Biology
Phillip T. Hawkins
Phillip T. Hawkins Babraham Institute
Alexander McPherson
Alexander McPherson University of California, Irvine
Matthias P. Wymann
Matthias P. Wymann University of Basel
Dmitry B. Veprintsev
Dmitry B. Veprintsev University of Nottingham
Matilda Katan
Matilda Katan University College London
Kevan M. Shokat
Kevan M. Shokat University of California, San Francisco
Robert V. Stahelin
Robert V. Stahelin Purdue University West Lafayette

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