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Biology and Biochemistry

D-Index
69
Citations
14290
World Ranking
7535
National Ranking
3424

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Aleem Siddiqui is affiliated with the University of California, San Diego in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad areas, Siddiqui has contributed significantly to subfields including Molecular Biology, Cancer Research, Oncology, Hepatology, and Rheumatology.

The main topics of Siddiqui's work revolve around RNA modifications and cancer, cancer-related molecular mechanisms research, and viral-associated cancers and disorders. Additional focuses include hepatitis C virus research, cancer-related gene regulation, interferon and immune responses, and HVDC systems and fault protection.

Siddiqui has published extensively in several scientific journals. The most frequent publication venues include:

  • Journal of Virology
  • Proceedings of the National Academy of Sciences
  • PLoS Pathogens
  • Frontiers in Cellular and Infection Microbiology
  • Hepatology

Recent papers authored or coauthored by Siddiqui showcase research on RNA modifications related to viral infections and cancer. These include:

  • HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC (2020, Hepatology)
  • N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling (2020, Journal of Biological Chemistry)
  • Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts (2020, PLoS Pathogens)
  • Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs (2021, Proceedings of the National Academy of Sciences)
  • N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition (2021, Proceedings of the National Academy of Sciences)

Collaborations form a key part of Siddiqui's research, with frequent coauthors including Geon-Woo Kim, Hasan Imam, Mohsin Khan, Gulam Waris, and Jae-Su Moon. These partnerships span multiple publications and research directions.

Siddiqui was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2019.

Best Publications

  • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-κB

    Guozhong Gong;Gulam Waris;Rasheeda Tanveer;Aleem Siddiqui

  • Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism.

    Changyu Wang;P. Sarnow;Aleem Siddiqui

  • HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions.

    Hugh F. Maguire;James P. Hoeffler;Aleem Siddiqui

  • Hepatitis C virus hijacks host lipid metabolism

    Gulam H. Syed;Yutaka Amako;Aleem Siddiqui

  • The La antigen binds 5′ noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation

    Naushad Ali;Aleem Siddiqui

  • Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress.

    Gulam Waris;Kyung-Won Huh;Aleem Siddiqui

  • Hepatitis B Virus X Protein Colocalizes to Mitochondria with a Human Voltage-Dependent Anion Channel, HVDAC3, and Alters Its Transmembrane Potential

    Zohra Rahmani;Kyung-Won Huh;Robert Lasher;Aleem Siddiqui

  • An RNA pseudoknot is an essential structural element of the internal ribosome entry site located within the hepatitis C virus 5' noncoding region.

    Changyu Wang;Shu Yun Le;Naushad Ali;Aleem Siddiqui

  • Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway

    Keith D. Tardif;Kazutoshi Mori;Aleem Siddiqui

  • Hepatitis C virus, ER stress, and oxidative stress.

    Keith D. Tardif;Gulam Waris;Aleem Siddiqui

  • Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress

    Gulam Waris;Daniel Jeffery Felmlee;Francesco Negro;Aleem Siddiqui

  • Hepatitis B Virus Disrupts Mitochondrial Dynamics: Induces Fission and Mitophagy to Attenuate Apoptosis

    Seong-Jun Kim;Mohsin Khan;Jun Quan;Andreas Till

  • Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence

    Seong-Jun Kim;Gulam H. Syed;Mohsin Khan;Wei-Wei Chiu

  • Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response.

    Keith D. Tardif;Kazutoshi Mori;Randal J. Kaufman;Aleem Siddiqui

  • Pestivirus translation initiation occurs by internal ribosome entry.

    Toni L. Poole;Changyu Wang;R.A. Popp;L.N.D. Potgieter

  • Hepatitis B virus transactivator protein X interacts with the TATA-binding protein

    Ishtiaq Qadri;Hugh F. Maguire;Aleem Siddiqui

  • Human La Antigen Is Required for the Hepatitis C Virus Internal Ribosome Entry Site-mediated Translation

    Naushad Ali;Ger J.M. Pruijn;Daniel James Kenan;Jack D. Keene

  • N6 -methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle.

    Hasan Imam;Mohsin Khan;Nandan S. Gokhale;Alexa B. R. McIntyre

  • A conserved helical element is essential for internal initiation of translation of hepatitis C virus RNA.

    Changyu Wang;P. Sarnow;A. Siddiqui

  • trans-Activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein

    A Siddiqui;R Gaynor;A Srinivasan;J Mapoles

Frequent Co-Authors

Shahid Jameel
Shahid Jameel Ashoka University
Dwayne G. Stupack
Dwayne G. Stupack University of California, San Diego
Manuel López-Cabrera
Manuel López-Cabrera Spanish National Research Council
Jerome Schaack
Jerome Schaack University of Colorado Anschutz Medical Campus
Marilyn J. Roossinck
Marilyn J. Roossinck Pennsylvania State University
Sergio Lavandero
Sergio Lavandero University of Chile
Albena T. Dinkova-Kostova
Albena T. Dinkova-Kostova University of Dundee
Vladimir N. Uversky
Vladimir N. Uversky University of South Florida
Peter Sarnow
Peter Sarnow Stanford University
Kazutoshi Mori
Kazutoshi Mori Kyoto University

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