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Biology and Biochemistry

D-Index
77
Citations
18275
World Ranking
4857
National Ranking
91

Overview

Nicole Déglon is affiliated with the University of Lausanne in Switzerland and works primarily within the fields of Biochemistry, Genetics and Molecular Biology, as well as Neuroscience. Their research portfolio includes 49 publications in biochemistry and molecular biology and 28 in neuroscience, highlighting a focus on molecular mechanisms and cellular processes.

The scientist's research delves into multiple subfields, including Molecular Biology (40 publications), Cellular and Molecular Neuroscience (19 publications), Physiology (9 publications), Neurology (7 publications), and Genetics (6 publications). These areas underscore a concentration on the molecular and cellular underpinnings of neurological processes and diseases.

Main topics of Nicole Déglon's work comprise:

  • CRISPR and Genetic Engineering
  • Neuroscience and Neuropharmacology Research
  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Mitochondrial Function and Pathology
  • Genetic Neurodegenerative Diseases
  • Virus-based gene therapy research

Nicole Déglon has published recent papers that address various aspects of neuroscience and molecular biology:

  • "Glucose metabolism links astroglial mitochondria to cannabinoid effects" (2020, Nature)
  • "Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease" (2020, Nature Neuroscience)
  • "Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation" (2021, Cell Reports)
  • "Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance" (2021, Proceedings of the National Academy of Sciences)
  • "Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies" (2021, Molecular Therapy)

Frequent coauthors collaborating with Nicole Déglon include María Rey, Séverine Bégard, Paola Bezzi, Luc Buée, and Mélanie Sipion. These collaborations appear recurrently across published works, indicating active research partnerships.

Their publications often appear in selected scientific venues, with multiple papers in "Gene Therapy" and "Frontiers in Neuroscience," and additional contributions to "Biological Psychiatry," "Human Gene Therapy," and "bioRxiv (Cold Spring Harbor Laboratory)."

Best Publications

  • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.

    Jeffrey H. Kordower;Marina E. Emborg;Jocelyne Bloch;Shuang Y. Ma

  • α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease

    C. Lo Bianco;J. L. Ridet;B. L. Schneider;N. Deglon

  • Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients.

    Patrick Aebischer;Myriam Schluep;Nicole Déglon;Jean-Marc Joseph

  • Lentiviral-Mediated RNA Interference

    Toufik Abbas-Terki;William Blanco-Bose;Nicole Déglon;William Pralong

  • Isolation of multipotent neural precursors residing in the cortex of the adult human brain.

    Yvan Arsenijevic;Jean-Guy Villemure;Jean-François Brunet;Jocelyne J. Bloch

  • In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's Disease subjects

    Mathilde Faideau;Jinho Kim;Kerry Cormier;Richard Gilmore

  • Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

    Ulrike Pannasch;Dominik Freche;Glenn Dallérac;Grégory Ghézali

  • Self-Inactivating Lentiviral Vectors with Enhanced Transgene Expression as Potential Gene Transfer System in Parkinson's Disease

    N. Déglon;J. L. Tseng;J.C. Bensadoun;A. D. Zurn

  • Mitochondria in Huntington's disease

    Maria Damiano;Laurie Galvan;Laurie Galvan;Nicole Déglon;Nicole Déglon;Emmanuel Brouillet;Emmanuel Brouillet

  • The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

    Lucile Ben Haim;Lucile Ben Haim;Kelly Ceyzériat;Kelly Ceyzériat;Maria Angeles Carrillo-de Sauvage;Maria Angeles Carrillo-de Sauvage;Fabien Aubry;Fabien Aubry

  • Lentiviral-Mediated Delivery of Mutant Huntingtin in the Striatum of Rats Induces a Selective Neuropathology Modulated by Polyglutamine Repeat Size, Huntingtin Expression Levels, and Protein Length

    Luis Pereira de Almeida;Christopher A. Ross;Diana Zala;Diana Zala;Patrick Aebischer;Patrick Aebischer

  • Involvement of Mitochondrial Complex II Defects in Neuronal Death Produced by N-Terminus Fragment of Mutated Huntingtin

    Alexandra Benchoua;Yaël Trioulier;Diana Zala;Marie-Claude Gaillard

  • Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

    Simon Dujardin;Simon Dujardin;Katia Lécolle;Katia Lécolle;Raphaëlle Caillierez;Raphaëlle Caillierez;Séverine Bégard;Séverine Bégard

  • Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study.

    J. Bloch;A.C. Bachoud-Lévi;N. Déglon;J.P. Lefaucheur

  • BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

    G Quesseveur;D J David;M C Gaillard;M C Gaillard;P Pla

  • Sustained effects of nonallele-specific Huntingtin silencing†

    Valérie Drouet;Valérie Drouet;Valérie Perrin;Raymonde Hassig;Raymonde Hassig;Noëlle Dufour;Noëlle Dufour

  • Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration

    Stephane Palfi;Stephane Palfi;Liza Leventhal;Yaping Chu;Shuang Y. Ma

  • Lentiviral vectors as a gene delivery system in the mouse midbrain : Cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF

    Jean-Charles Bensadoun;Nicole Déglon;Jack L. Tseng;Jean-Luc Ridet

  • Lentiviral gene transfer to the nonhuman primate brain.

    Jeffrey H Kordower;Jocelyne Bloch;Shuang Y Ma;Yaping Chu

  • Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

    Alexander Huber;Vivianne Padrun;Nicole Déglon;Patrick Aebischer

Frequent Co-Authors

Patrick Aebischer
Patrick Aebischer École Polytechnique Fédérale de Lausanne
Philippe Hantraye
Philippe Hantraye University of Paris-Saclay
Emmanuel Brouillet
Emmanuel Brouillet Centre national de la recherche scientifique, CNRS
Gilles Bonvento
Gilles Bonvento University of Paris-Saclay
Luís Pereira de Almeida
Luís Pereira de Almeida University of Coimbra
Jocelyne Bloch
Jocelyne Bloch University of Lausanne
Luc Buée
Luc Buée University of Lille
Bernard L. Schneider
Bernard L. Schneider École Polytechnique Fédérale de Lausanne
Sandrine Humbert
Sandrine Humbert Grenoble Alpes University
Frédéric Saudou
Frédéric Saudou Grenoble Alpes University

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