2023 - Research.com Biology and Biochemistry in Switzerland Leader Award
Her scientific interests lie mostly in Neuroscience, Neurotrophic factors, Huntington's disease, Huntingtin and Striatum. Her research in Neurotrophic factors is mostly focused on Glial cell line-derived neurotrophic factor. Her studies deal with areas such as Glutamate receptor, Biochemistry, Ciliary neurotrophic factor and Genetic enhancement as well as Huntington's disease.
Her Huntingtin research incorporates elements of Molecular biology, Cancer research and Neurodegeneration. Her Neurodegeneration study integrates concerns from other disciplines, such as Genetics, Gene silencing and RNA interference. Her Striatum research is multidisciplinary, incorporating perspectives in Pharmacology and Pathology.
Her primary areas of investigation include Huntingtin, Cell biology, Neuroscience, Huntington's disease and Molecular biology. Her studies in Huntingtin integrate themes in fields like Striatum and Neurodegeneration. Her Cell biology research includes themes of Programmed cell death, Astrocyte and Biochemistry.
The Neuroscience study combines topics in areas such as Glial cell line-derived neurotrophic factor, Neurotrophic factors and Viral vector. Her study in Huntington's disease is interdisciplinary in nature, drawing from both Neurotoxicity, Endocrinology and Neuroprotection. Her Molecular biology research includes elements of Cell culture, Gene expression, Transgene, NeuN and RNA interference.
Her main research concerns Huntingtin, Neuroscience, Cell biology, Huntington's disease and Viral vector. Her Huntingtin research is multidisciplinary, relying on both Gene silencing and Striatum. Her study in the field of Astrocyte, Dopamine and Hippocampal formation also crosses realms of Prefrontal cortex.
The various areas that Nicole Déglon examines in her Cell biology study include Small hairpin RNA, Downregulation and upregulation and Gene isoform. Her research investigates the connection between Huntington's disease and topics such as Endocrinology that intersect with issues in Neuron. Her Viral vector study combines topics in areas such as Cell culture, Cell type and Induced pluripotent stem cell.
Nicole Déglon mostly deals with Cell biology, Huntingtin, Neuroscience, Gene and Huntington's disease. Her research integrates issues of Small hairpin RNA, Gene silencing and microRNA in her study of Cell biology. Her work deals with themes such as Endocrinology and Energy homeostasis, which intersect with Huntingtin.
Nicole Déglon has included themes like Gene expression and Janus kinase in her Neuroscience study. Her Huntington's disease research is multidisciplinary, incorporating perspectives in AMP-activated protein kinase, AMPK, Neuron, Activator and Programmed cell death. Her Mutant study combines topics in areas such as Non-coding RNA, Cancer research, Neurodegeneration, RNA interference and Genetic enhancement.
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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.
Jeffrey H. Kordower;Marina E. Emborg;Jocelyne Bloch;Shuang Y. Ma.
α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
C. Lo Bianco;J. L. Ridet;B. L. Schneider;N. Deglon.
Proceedings of the National Academy of Sciences of the United States of America (2002)
Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients.
Patrick Aebischer;Myriam Schluep;Nicole Déglon;Jean-Marc Joseph.
Nature Medicine (1996)
Lentiviral-Mediated RNA Interference
Toufik Abbas-Terki;William Blanco-Bose;Nicole Déglon;William Pralong.
Human Gene Therapy (2002)
Isolation of multipotent neural precursors residing in the cortex of the adult human brain.
Yvan Arsenijevic;Jean-Guy Villemure;Jean-François Brunet;Jocelyne J. Bloch.
Experimental Neurology (2001)
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's Disease subjects
Mathilde Faideau;Jinho Kim;Kerry Cormier;Richard Gilmore.
Human Molecular Genetics (2010)
Self-Inactivating Lentiviral Vectors with Enhanced Transgene Expression as Potential Gene Transfer System in Parkinson's Disease
N. Déglon;J. L. Tseng;J.C. Bensadoun;A. D. Zurn.
Human Gene Therapy (2000)
Mitochondria in Huntington's disease
Maria Damiano;Laurie Galvan;Laurie Galvan;Nicole Déglon;Nicole Déglon;Emmanuel Brouillet;Emmanuel Brouillet.
Biochimica et Biophysica Acta (2010)
Lentiviral-Mediated Delivery of Mutant Huntingtin in the Striatum of Rats Induces a Selective Neuropathology Modulated by Polyglutamine Repeat Size, Huntingtin Expression Levels, and Protein Length
Luis Pereira de Almeida;Christopher A. Ross;Diana Zala;Diana Zala;Patrick Aebischer;Patrick Aebischer.
The Journal of Neuroscience (2002)
Connexin 30 sets synaptic strength by controlling astroglial synapse invasion
Ulrike Pannasch;Dominik Freche;Glenn Dallérac;Grégory Ghézali.
Nature Neuroscience (2014)
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