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Biology and Biochemistry

D-Index
51
Citations
13901
World Ranking
16973
National Ranking
715

Overview

Sandrine Humbert is affiliated with Grenoble Alpes University in France. Their research primarily focuses on genetic neurodegenerative diseases, with a strong emphasis on Huntington's disease. The scientist's work spans the fields of biochemistry, genetics and molecular biology, neuroscience, and medicine.

The main topics of Humbert's research include:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Neurological Disorders and Treatments
  • Neuroscience and Neuropharmacology Research
  • Microtubule and Mitosis Dynamics
  • Ion Channel Regulation and Function
  • Parkinson's Disease Mechanisms and Treatments

The subfields contributing to their work cover cellular and molecular neuroscience, molecular biology, neurology, cell biology, and physiology. Humbert's publications are present across numerous scientific venues, predominantly in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • Science
  • eLife
  • Neuron

Recent representative publications include:

  • "Huntington's disease alters human neurodevelopment," 2020, Science
  • "Propensity for somatic expansion increases over the course of life in Huntington disease," 2021, eLife
  • "Treating early postnatal circuit defect delays Huntington's disease onset and pathology in mice," 2022, Science
  • "Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice," 2021, Science Advances
  • "Developmental defects in Huntington's disease show that axonal growth and microtubule reorganization require NUMA1," 2021, Neuron

The scientist frequently collaborates with a set of coauthors, including Frédéric Saudou, Alexandra Dürr, Mariacristina Capizzi, Barbara Y. Braz, and Rémi Carpentier, indicative of a collaborative research environment centered on neuroscience and molecular biology.

Best Publications

  • Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules

    Laurent R Gauthier;Bénédicte C Charrin;Maria Borrell-Pagès;Jim P Dompierre

  • DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor

    Laurent Schaeffer;Richard Roy;Sandrine Humbert;Vincent Moncollin

  • The Biology of Huntingtin

    Frédéric Saudou;Frédéric Saudou;Sandrine Humbert;Sandrine Humbert

  • Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation

    Jim P. Dompierre;Juliette D. Godin;Bénédicte C. Charrin;Fabrice P. Cordelières

  • The IGF-1/Akt Pathway Is Neuroprotective in Huntington's Disease and Involves Huntingtin Phosphorylation by Akt

    Sandrine Humbert;Elzbieta A. Bryson;Fabrice P. Cordelières;Nathan C. Connors

  • Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth

    Lawrence R. Zukerberg;Gentry N. Patrick;Margareta Nikolic;Sandrine Humbert

  • p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment

    Jane Ko;Sandrine Humbert;Roderick T. Bronson;Satoru Takahashi

  • Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

    Emilie Colin;Diana Zala;Diana Zala;Géraldine Liot;Géraldine Liot;Hélène Rangone;Hélène Rangone

  • Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis

    Juliette D. Godin;Kelly Colombo;Kelly Colombo;Kelly Colombo;Maria Molina-Calavita;Maria Molina-Calavita;Maria Molina-Calavita;Guy Keryer;Guy Keryer;Guy Keryer

  • Huntington’s disease alters human neurodevelopment

    Monia Barnat;Mariacristina Capizzi;Esther Aparicio;Susana Boluda

  • Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

    Alison E. Twelvetrees;Eunice Y. Yuen;I. Lorena Arancibia-Carcamo;Andrew F. MacAskill

  • Potential function for the Huntingtin protein as a scaffold for selective autophagy.

    Joseph Ochaba;Tamás Lukacsovich;George Csikos;Shuqiu Zheng

  • Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

    M Borrell-Pagès;M Borrell-Pagès;D Zala;S Humbert;F Saudou

  • p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

    Sandrine Humbert;Rani Dhavan;Li-Huei Tsai

  • Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

    Maria Borrell-Pagès;Josep M. Canals;Fabrice P. Cordelières;J. Alex Parker

  • Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

    Chrystelle Aillaud;Chrystelle Aillaud;Christophe Bosc;Christophe Bosc;Leticia Peris;Leticia Peris;Anouk Bosson;Anouk Bosson

  • The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin

    Hélène Rangone;Ghislaine Poizat;Juan Troncoso;Christopher A. Ross

  • Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons

    Diana Zala;Emilie Colin;Emilie Colin;Hélène Rangone;Hélène Rangone;Géraldine Liot;Géraldine Liot

  • Akt is altered in an animal model of Huntington's disease and in patients.

    Emilie Colin;Etienne Régulier;Valérie Perrin;Alexandra Dürr

  • Human Genome & Diseases: Review Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies

    M. Borrell-Pagès;D. Zala;S. Humbert;F. Saudou

Frequent Co-Authors

Frédéric Saudou
Frédéric Saudou Grenoble Alpes University
Alexandra Durr
Alexandra Durr Sorbonne University
Nicole Déglon
Nicole Déglon University of Lausanne
Emmanuel Brouillet
Emmanuel Brouillet Centre national de la recherche scientifique, CNRS
Jean-Marc Egly
Jean-Marc Egly Institute of Genetics and Molecular and Cellular Biology
Annie Andrieux
Annie Andrieux Grenoble Alpes University
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Alexis Brice
Alexis Brice Institut du Cerveau
Marc Remke
Marc Remke German Cancer Research Center

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