World's Best Scientists 2026 revealed!
Xiao-Jiang Li

Xiao-Jiang Li

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Biology and Biochemistry
China
2023

D-Index & Metrics

Neuroscience

D-Index
92
Citations
30389
World Ranking
1027
National Ranking
14

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in China Leader Award

Overview

Xiao-Jiang Li is affiliated with Jinan University in China and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine. Their work spans several subfields, including Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Genetics, and Physiology.

The main topics covered in their research include Genetic Neurodegenerative Diseases, Mitochondrial Function and Pathology, Muscle Physiology and Disorders, Amyotrophic Lateral Sclerosis Research, Parkinson's Disease Mechanisms and Treatments, Neurological disorders and treatments, and Neurological diseases and metabolism.

Among Xiao-Jiang Li's notable recent publications are:

  • "PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models", 2022, Autophagy
  • "Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form", 2020, Nature Communications
  • "Huntington's Disease: Complex Pathogenesis and Therapeutic Strategies", 2024, International Journal of Molecular Sciences
  • "PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis", 2021, Protein & Cell
  • "New pathogenic insights from large animal models of neurodegenerative diseases", 2022, Protein & Cell

Xiao-Jiang Li has frequently published in the following venues:

  • Autophagy
  • Nature Communications
  • International Journal of Molecular Sciences
  • Frontiers in Cell and Developmental Biology
  • Ageing and Neurodegenerative Diseases

The scientist has collaborated extensively with several frequent co-authors, including:

  • Shihua Li
  • Peng Yin
  • Sen Yan
  • Weili Yang
  • Su Yang

Best Publications

  • Nuclear and Neuropil Aggregates in Huntington’s Disease: Relationship to Neuropathology

    Claire-Anne Gutekunst;Shi-Hua Li;Hong Yi;James S. Mulroy

  • A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

    J.Graeme Hodgson;Nadia Agopyan;Claire-Anne Gutekunst;Blair R Leavitt

  • Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

    Elizabeth J. Slow;Jeremy van Raamsdonk;Daniel Rogers;Sarah H. Coleman

  • Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

    Victor O. Ona;Mingwei Li;Jean Paul G. Vonsattel;L. John Andrews

  • A huntingtin-associated protein enriched in brain with implications for pathology

    Xiao-Jiang Li;Shi-Hua Li;Alan H. Sharp;Frederick C. Nucifora

  • Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

    Michelle Gray;Dyna I. Shirasaki;Carlos Cepeda;Véronique M. André

  • Huntingtin–protein interactions and the pathogenesis of Huntington's disease

    Shi-Hua Li;Xiao-Jiang Li

  • Neurological abnormalities in a knock-in mouse model of Huntington’s disease

    Chin Hsing Lin;Sara Tallaksen-Greene;Wei Ming Chien;Jamie A. Cearley

  • Widespread expression of Huntington's disease gene (IT15) protein product

    Alan H. Sharp;Scott J. Loev;Gabriele Schilling;Shi Hua Li

  • The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

    Lucia Pastorino;Anyang Sun;Anyang Sun;Pei-Jung Lu;Xiao Zhen Zhou

  • Towards a transgenic model of Huntington’s disease in a non-human primate

    Shang Hsun Yang;Pei Hsun Cheng;Heather Banta;Karolina Piotrowska-Nitsche;Karolina Piotrowska-Nitsche

  • Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

    Ji-Yeon Shin;Zhi-Hui Fang;Zhao-Xue Yu;Chuan-En Wang

  • Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

    Vanessa C. Wheeler;Jacqueline K. White;Claire-Anne Gutekunst;Vladimir Vrbanac

  • Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration

    Yih-Cherng Liou;Anyang Sun;Anyang Sun;Akihide Ryo;Akihide Ryo;Xiao Zhen Zhou

  • Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

    Wenzhen Duan;Zhihong Guo;Haiyang Jiang;Melvin Ware

  • Huntingtin aggregates may not predict neuronal death in Huntington's disease

    S Kuemmerle;C A Gutekunst;A M Klein;A M Klein;X J Li

  • N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

    Adam L. Orr;Shihua Li;Chuan-En Wang;He Li

  • Huntingtin Aggregate-Associated Axonal Degeneration is an Early Pathological Event in Huntington's Disease Mice

    He Li;Shi-Hua Li;Zhao-Xue Yu;Peggy Shelbourne

  • Interaction of Huntington disease protein with transcriptional activator Sp1.

    Shi-Hua Li;Anna L. Cheng;Hui Zhou;Suzanne Lam

  • CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease

    Su Yang;Renbao Chang;Renbao Chang;Huiming Yang;Ting Zhao

  • Transgenic rat model of Huntington's disease

    Stephan von Hörsten;Ina Schmitt;Huu Phuc Nguyen;Carsten Holzmann

  • Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

    Jennifer Bradford;Ji Yeon Shin;Meredith Roberts;Chuan En Wang

  • Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

    He Li;Shi-Hua Li;Heather Johnston;Peggy F. Shelbourne

Frequent Co-Authors

Shihua Li
Shihua Li Southeast University
Solomon H. Snyder
Solomon H. Snyder Johns Hopkins University School of Medicine
Gillian P. Bates
Gillian P. Bates University College London
Véronique M. André
Véronique M. André UCB Pharma (Belgium)
Xin-Fu Zhou
Xin-Fu Zhou University of South Australia
Samuel Saporta
Samuel Saporta University of South Florida
Yong-hui Jiang
Yong-hui Jiang Yale School of Medicine
Lin Mei
Lin Mei Case Western Reserve University
Michael S. Levine
Michael S. Levine Princeton University
Robert J. Ferrante
Robert J. Ferrante Boston University

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