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Neuroscience

D-Index
90
Citations
36249
World Ranking
1099
National Ranking
569

Biology and Biochemistry

D-Index
90
Citations
36390
World Ranking
2402
National Ranking
1274

Overview

Marian DiFiglia is affiliated with Harvard University in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, neuroscience, and medicine, with a notable focus on molecular biology, cellular and molecular neuroscience, neurology, genetics, and cell biology as subfields of study.

The scientist's work revolves around several key topics, including genetic neurodegenerative diseases, mitochondrial function and pathology, neurological disorders and treatments, RNA research and splicing, RNA interference and gene delivery, advanced biosensing and bioanalysis techniques, and CRISPR and genetic engineering.

Marian DiFiglia has contributed to numerous research papers across various prestigious journals and publication venues. Their frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory) with 13 publications, Journal of Huntington's Disease with 3 publications, Molecular Therapy and Nucleic Acids Research with 2 publications each, and Neurobiology of Disease with 2 publications.

Their notable recent papers include:

  • Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease (2023), published in Molecular Therapy
  • Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis (2021), published in Molecular Neurobiology
  • Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models (2022), published in Nature Communications
  • Protein changes in synaptosomes of Huntington's disease knock-in mice are dependent on age and brain region (2020), published in Neurobiology of Disease
  • Trappc9 deficiency in mice impairs learning and memory by causing imbalance of dopamine D1 and D2 neurons (2020), published in Science Advances

Throughout their career, Marian DiFiglia has frequently collaborated with several co-authors, including Ellen Sapp, Neil Aronin, Anastasia Khvorova, Adel Boudi, and Rachael Miller. Their collaborative work reflects intersections in neurodegenerative disease research and molecular therapeutic approaches.

Best Publications

  • Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

    Marian DiFiglia;Ellen Sapp;Kathryn O. Chase;Stephen W. Davies

  • FORMATION OF NEURONAL INTRANUCLEAR INCLUSIONS UNDERLIES THE NEUROLOGICAL DYSFUNCTION IN MICE TRANSGENIC FOR THE HD MUTATION

    Stephen W Davies;Mark Turmaine;Barbara A Cozens;Marian DiFiglia

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons.

    Marian DiFiglia;Ellen Sapp;Kathryn Chase;Cordula Schwarz

  • Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

    GA Graveland;RS Williams;M DiFiglia

  • High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

    Reka A. Haraszti;Marie-Cecile Didiot;Ellen Sapp;John D. Leszyk

  • Excitotoxic injury of the neostriatum: a model for Huntington's disease

    Marian DiFiglia

  • Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

    Kimberly B. Kegel;Manho Kim;Ellen Sapp;Charmian McIntyre

  • Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome.

    Paul S. A. Kalanithi;Wei Zheng;Yuko Kataoka;Marian DiFiglia

  • Early and progressive accumulation of reactive microglia in the Huntington disease brain.

    E. Sapp;K. B. Kegel;N. Aronin;T. Hashikawa

  • Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis

    Yun J. Kim;Yong Yi;Ellen Sapp;Yumei Wang

  • Autophagy and its possible roles in nervous system diseases, damage and repair.

    David C Rubinsztein;Marian DiFiglia;Nathaniel Heintz;Ralph A Nixon

  • Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity

    Reka Agnes Haraszti;Rachael Miller;Matteo Stoppato;Yves Y. Sere

  • Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

    Marian DiFiglia;Miguel Sena-Esteves;Kathryn O. Chase;Ellen Sapp

  • Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

    Marie-Cécile Didiot;Lauren M Hall;Andrew H Coles;Reka A Haraszti

  • A Golgi study of neuronal types in the neostriatum of monkeys.

    Marian DiFiglia;Pedro Pasik;Tauba Pasik

  • Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

    Zhaoyang Li;Cen Wang;Ziying Wang;Chenggang Zhu

  • Huntingtin localization in brains of normal and Huntington's disease patients.

    E. Sapp;C. Schwarz;K. Chase;P. G. Bhide

  • The frequency and distribution of medium-sized neurons with indented nuclei in the primate and rodent neostriatum

    G.A. Graveland;M. Difiglia

  • Wild-Type and Mutant Huntingtins Function in Vesicle Trafficking in the Secretory and Endocytic Pathways

    James Velier;Manho Kim;Cordula Schwarz;Tae Wan Kim

  • Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.

    Edith L. Pfister;Lori A. Kennington;Juerg R. Straubhaar;Sujata Wagh

Frequent Co-Authors

Neil Aronin
Neil Aronin University of Massachusetts Chan Medical School
Anastasia Khvorova
Anastasia Khvorova University of Massachusetts Chan Medical School
Miguel Sena-Esteves
Miguel Sena-Esteves University of Massachusetts Chan Medical School
Anne B. Young
Anne B. Young Harvard University
Edward D. Bird
Edward D. Bird Harvard University
Manho Kim
Manho Kim Seoul National University Hospital
Scott A. Shaffer
Scott A. Shaffer San Jose State University
Steven M. Hersch
Steven M. Hersch Harvard University
Michael R. Hayden
Michael R. Hayden University of British Columbia
Pradeep G. Bhide
Pradeep G. Bhide Florida State University

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