What is he best known for?
The fields of study he is best known for:
Marian DiFiglia mainly investigates Huntingtin, Molecular biology, Huntingtin Protein, Huntington's disease and Neuroscience.
His biological study spans a wide range of topics, including Autophagy, RNA interference, Cell biology, Gene silencing and Endosome.
Marian DiFiglia has researched Molecular biology in several fields, including Cytoplasm, Genetically modified mouse, Transgene and Mutant protein, Mutant.
His studies deal with areas such as Neuropathology, Polyglutamine tract and Vesicle as well as Huntingtin Protein.
The concepts of his Huntington's disease study are interwoven with issues in Striatum, Pathogenesis, Neurodegeneration, Anatomy and Regeneration.
His Neuroscience study incorporates themes from Golgi apparatus and Programmed cell death.
His most cited work include:
- Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain (2335 citations)
- Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (1951 citations)
- FORMATION OF NEURONAL INTRANUCLEAR INCLUSIONS UNDERLIES THE NEUROLOGICAL DYSFUNCTION IN MICE TRANSGENIC FOR THE HD MUTATION (1947 citations)
What are the main themes of his work throughout his whole career to date?
Marian DiFiglia mostly deals with Huntingtin, Neuroscience, Cell biology, Huntington's disease and Molecular biology.
Marian DiFiglia studies Huntingtin Protein, a branch of Huntingtin.
His study looks at the relationship between Huntingtin Protein and fields such as Polyglutamine tract, as well as how they intersect with chemical problems.
His work on Axon, Neuropil, Synapse and Basal ganglia as part of general Neuroscience study is frequently linked to Dendritic spine, therefore connecting diverse disciplines of science.
His study in Cell biology is interdisciplinary in nature, drawing from both Microvesicles and Receptor, Biochemistry.
His Huntington's disease research incorporates elements of Striatum, Genetically modified mouse and Endocrinology.
He most often published in these fields:
- Huntingtin (44.69%)
- Neuroscience (31.84%)
- Cell biology (29.05%)
What were the highlights of his more recent work (between 2016-2021)?
- Cell biology (29.05%)
- Huntingtin (44.69%)
- Huntington's disease (27.37%)
In recent papers he was focusing on the following fields of study:
Marian DiFiglia mainly focuses on Cell biology, Huntingtin, Huntington's disease, Gene silencing and Small interfering RNA.
His Cell biology research includes elements of Motor cortex, In vitro, Amyotrophic lateral sclerosis and Pathogenesis.
His biological study focuses on Huntingtin Protein.
He combines subjects such as Autophagy, Autophagosome, Phenotype and Allele with his study of Huntingtin Protein.
His Huntington's disease research incorporates themes from Transgene, Signal transduction, Stem cell, Neural stem cell and Synapse.
His Gene silencing study combines topics in areas such as Cytoplasm, RNA, RNA interference, Messenger RNA and Pharmacology.
Between 2016 and 2021, his most popular works were:
- Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds (68 citations)
- Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity (65 citations)
- KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients (43 citations)
In his most recent research, the most cited papers focused on:
Marian DiFiglia spends much of his time researching Cell biology, Huntingtin, Gene silencing, Small interfering RNA and Messenger RNA.
His Cell biology research is multidisciplinary, incorporating perspectives in Huntington's disease, Ubiquitin ligase, Cell type and Microcarrier.
His research in Huntingtin is mostly focused on Huntingtin Protein.
The study incorporates disciplines such as Autophagy, Plasma protein binding, Allele and Phenotype in addition to Huntingtin Protein.
His research in Small interfering RNA focuses on subjects like Microvesicles, which are connected to RNA, Vesicle, Extracellular and Biophysics.
His research integrates issues of Gene expression and Central nervous system in his study of Messenger RNA.
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