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D-Index & Metrics

Biology and Biochemistry

D-Index
84
Citations
34497
World Ranking
3253
National Ranking
1645

Overview

Steven M. Hersch is affiliated with Harvard University in the United States and specializes in the field of Medicine. Their research spans a diverse range of subfields, notably including Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Physiology, and Psychiatry and Mental Health.

The scientist's work focuses on several main topics, such as:

  • Genetic Neurodegenerative Diseases
  • Alzheimer's disease research and treatments
  • Mitochondrial Function and Pathology
  • Neurological disorders and treatments
  • Dementia and Cognitive Impairment Research
  • Amyloidosis: Diagnosis, Treatment, Outcomes
  • Computational Drug Discovery Methods

Steven M. Hersch has an extensive publication record with notable frequent venues including:

  • Alzheimer's & Dementia
  • Neurology
  • PLoS ONE
  • Alzheimer's Research & Therapy
  • Movement Disorders

Frequent coauthors associated with their work are:

  • Lynn D. Kramer
  • Shobha Dhadda
  • Michael C. Irizarry
  • Michelle Gee
  • Michio Kanekiyo

Recent papers authored or coauthored by Steven M. Hersch demonstrate engagement with clinical and translational research related particularly to neurodegenerative diseases:

  • Updated safety results from phase 3 lecanemab study in early Alzheimer's disease (2024), published in Alzheimer's Research & Therapy
  • Lecanemab Clarity AD: Quality-of-Life Results from a Randomized, Double-Blind Phase 3 Trial in Early Alzheimer's Disease (2023), published in The Journal of Prevention of Alzheimer's Disease
  • Association of Dilated Perivascular Spaces and Disease Severity in Patients With Huntington Disease (2020), published in Neurology
  • Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington's Disease Patients-A Randomized Phase 2 Clinical Trial (2020), published in Journal of Clinical Medicine
  • Clinical Outcomes and Selection Criteria for Prodromal Huntington's Disease Trials (2020), published in Movement Disorders

These publications reflect specific attention to early-stage clinical trials and biomarkers in Alzheimer's and Huntington's diseases, contributing to understanding disease severity, safety of therapeutic agents, and patient-related outcomes.

Best Publications

  • Unified huntington’s disease rating scale: Reliability and consistency

    Karl Kieburtz;John B. Penney;Peter Corno;Neal Ranen

  • Regional and progressive thinning of the cortical ribbon in Huntington's disease

    H. D. Rosas;A. K. Liu;S. Hersch;M. Glessner

  • Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

    Ivan A Klement;Pamela J Skinner;Michael D Kaytor;Hong Yi

  • Nuclear and Neuropil Aggregates in Huntington’s Disease: Relationship to Neuropathology

    Claire-Anne Gutekunst;Shi-Hua Li;Hong Yi;James S. Mulroy

  • Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

    Nancy S. Wexler;Judith Lorimer;Julie Porter;Fidela Gomez

  • A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

    J.Graeme Hodgson;Nadia Agopyan;Claire-Anne Gutekunst;Blair R Leavitt

  • Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease

    Anthone W. Dunah;Hyunkyung Jeong;April Griffin;Yong Man Kim

  • Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

    Robert J. Ferrante;James K. Kubilus;Junghee Lee;Hoon Ryu

  • Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies.

    Allan I. Levey;Steven M. Hersch;David B. Rye;Roger K. Sunahara

  • Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

    William Dauer;Nikolai Kholodilov;Miquel Vila;Anne Cecile Trillat

  • The dopamine transporter: immunochemical characterization and localization in brain

    BJ Ciliax;C Heilman;LL Demchyshyn;ZB Pristupa

  • Immunocytochemical localization of D1 and D2 dopamine receptors in the basal ganglia of the rat: Light and electron microscopy

    K.K.L. Yung;J.P. Bolam;A.D. Smith;S.M. Hersch

  • Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

    Robert J. Ferrante;Ole A. Andreassen;Bruce G. Jenkins;Alpaslan Dedeoglu

  • Fragile X Mental Retardation Protein: Nucleocytoplasmic Shuttling and Association with Somatodendritic Ribosomes

    Yue Feng;Claire-Anne Gutekunst;Derek E. Eberhart;Hong Yi

  • Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity.

    H. Diana Rosas;David H. Salat;Stephanie Y. Lee;Alexandra K. Zaleta

  • Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents.

    S. M. Hersch;B. J. Ciliax;C.-A. Gutekunst;H. D. Rees

  • Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

    Vanessa C. Wheeler;Jacqueline K. White;Claire-Anne Gutekunst;Vladimir Vrbanac

  • Huntingtin aggregates may not predict neuronal death in Huntington's disease

    S Kuemmerle;C A Gutekunst;A M Klein;A M Klein;X J Li

  • Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease

    F. Borovecki;L. Lovrecic;J. Zhou;H. Jeong

  • Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

    Cheryl L. Wellington;Lisa M. Ellerby;Claire-Anne Gutekunst;Danny Rogers

Frequent Co-Authors

Robert J. Ferrante
Robert J. Ferrante Boston University
H. Diana Rosas
H. Diana Rosas Massachusetts General Hospital
Marcy E. MacDonald
Marcy E. MacDonald Harvard University
James F. Gusella
James F. Gusella Harvard University
Michael R. Hayden
Michael R. Hayden University of British Columbia
Karen Marder
Karen Marder Columbia University
Anne B. Young
Anne B. Young Harvard University
Christopher A. Ross
Christopher A. Ross Johns Hopkins University School of Medicine
Richard H. Myers
Richard H. Myers Boston University
Allan I. Levey
Allan I. Levey Emory University

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