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Genetics
UK
2024

D-Index & Metrics

Genetics

D-Index
105
Citations
64756
World Ranking
616
National Ranking
92

Medicine

D-Index
105
Citations
64721
World Ranking
6651
National Ranking
645

Research.com Recognitions

  • 2024 - Research.com Genetics in United Kingdom Leader Award
  • 2023 - Research.com Genetics in United Kingdom Leader Award

Overview

Gillian P. Bates is affiliated with University College London in the United Kingdom. Their research primarily focuses on molecular and cellular mechanisms underlying neurodegenerative diseases, particularly Huntington's disease.

The main fields of study associated with their work are Biochemistry, Genetics and Molecular Biology, and Neuroscience. Within these broader fields, Bates's work is specialized in subfields including Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Genetics, and Cell Biology.

The key research topics covered in their publications include Genetic Neurodegenerative Diseases, Mitochondrial Function and Pathology, Muscle Physiology and Disorders, Neurological Disorders and Treatments, RNA Research and Splicing, Cardiomyopathy and Myosin Studies, and Endoplasmic Reticulum Stress and Disease.

Some of their recent notable papers are:

  • "FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease" (2021), published in Cell Reports
  • "Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington'S Disease Model" (2020), published in Brain Communications
  • "Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice" (2022), published in Neuron
  • "TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models" (2020), published in The EMBO Journal
  • "A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease" (2024), published in Brain

Bates frequently collaborates with other researchers. Their most common coauthors include:

  • Christian Landles (17 coauthored works)
  • Kirupa Sathasivam (13 coauthored works)
  • Georgina F Osborne (10 coauthored works)
  • Edward J. Smith (10 coauthored works)
  • Jemima Phillips (7 coauthored works)

The scientist has published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), Brain Communications, Brain, Scientific Reports, and Neuron. These journals represent prominent platforms within their research areas and reflect the scope of their published contributions.

Best Publications

  • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

    Marcy E. MacDonald;Christine M. Ambrose;Mabel P. Duyao;Richard H. Myers

  • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

    M Shah;N Datson;L Srinidhi;VP Stanton

  • Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

    Laura Mangiarini;Kirupa Sathasivam;Mary Seller;Barbara Cozens

  • Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

    Marian DiFiglia;Ellen Sapp;Kathryn O. Chase;Stephen W. Davies

  • FORMATION OF NEURONAL INTRANUCLEAR INCLUSIONS UNDERLIES THE NEUROLOGICAL DYSFUNCTION IN MICE TRANSGENIC FOR THE HD MUTATION

    Stephen W Davies;Mark Turmaine;Barbara A Cozens;Marian DiFiglia

  • Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

    Eberhard Scherzinger;Rudi Lurz;Mark Turmaine;Laura Mangiarini

  • Huntington's disease

    Gillian Bates;K P S J Murphy;P Harper;L Jones

  • Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

    R. J. Carter;L. A. Lione;Trevor Humby;L. Mangiarini

  • The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

    Joan S. Steffan;Aleksey Kazantsev;Olivera Spasic-Boskovic;Marilee Greenwald

  • Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

    E. Hockly;V.M. Richon;B. Woodman;D.L. Smith

  • Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington’s disease pathology

    Eberhard Scherzinger;Annie Sittler;Katja Schweiger;Volker Heiser

  • Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene

    Jang-Ho J. Cha;Christoph M. Kosinski;Julie A. Kerner;Stephen A. Alsdorf

  • A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

    Maria Björkqvist;Edward J. Wild;Jenny Thiele;Aurelio Silvestroni

  • Huntingtin aggregation and toxicity in Huntington's disease.

    Gillian Bates

  • A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis

    M. Town;G. Jean;S. Cherqui;M. Attard

  • Huntingtin and the molecular pathogenesis of Huntington's disease Fourth in Molecular Medicine Review Series

    Christian Landles;Gillian P Bates

  • Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

    Mark Turmaine;Aysha Raza;Amarbirpal Mahal;Laura Mangiarini

  • Intranuclear Neuronal Inclusions in Huntington's Disease and Dentatorubral and Pallidoluysian Atrophy: Correlation between the Density of Inclusions andIT15CAG Triplet Repeat Length

    Mark W. Becher;Joyce A. Kotzuk;Alan H. Sharp;Stephen W. Davies

  • Global changes to the ubiquitin system in Huntington's disease

    Eric J. Bennett;Thomas A. Shaler;Ben Woodman;Kwon-Yul Ryu

  • Formation of neuronal intranuclear inclusions (NII) underlies the neurological dysfunction in mice transgenic for the HD mutation

    SW Davies;M Turmaine;BA Cozens;L Mangiarini

Frequent Co-Authors

Erich E. Wanker
Erich E. Wanker Max Delbrück Center for Molecular Medicine
Sarah J. Tabrizi
Sarah J. Tabrizi University College London
Marcy E. MacDonald
Marcy E. MacDonald Harvard University
Hans Lehrach
Hans Lehrach Max Planck Society
James F. Gusella
James F. Gusella Harvard University
John J. Wasmuth
John J. Wasmuth University of California, Irvine
Leslie M. Thompson
Leslie M. Thompson University of California, Irvine
Martin Farrall
Martin Farrall University of Oxford
Robert Williamson
Robert Williamson University of Melbourne

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