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Medicine

D-Index
108
Citations
39802
World Ranking
6041
National Ranking
589

Overview

Sarah J. Tabrizi is affiliated with University College London in the United Kingdom. Their research focuses on various aspects of neuroscience, biochemistry, genetics, molecular biology, and medicine, with a particular emphasis on neurodegenerative diseases and neurological disorders.

The scientist has published extensively on topics related to genetic neurodegenerative diseases, mitochondrial function and pathology, neurological disorders and treatments, functional brain connectivity studies, muscle physiology and disorders, RNA research and splicing, and advanced neuroimaging techniques and applications.

Notable recent papers include:

  • Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities (2020, Nature Reviews Neurology)
  • Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities (2022, The Lancet Neurology)
  • A biological classification of Huntington's disease: the Integrated Staging System (2022, The Lancet Neurology)
  • Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington's disease Young Adult Study (HD-YAS): a cross-sectional analysis (2020, The Lancet Neurology)
  • Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington's disease (2020, Science Translational Medicine)

Frequent co-authors collaborating with Sarah J. Tabrizi include:

  • Rachael I. Scahill
  • Geraint Rees
  • Edward J. Wild
  • Carlos Estevez-Fraga
  • Michael Flower

The scientist's work is published frequently in a range of venues with multiple publications in:

  • Journal of Huntington's Disease
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Movement Disorders
  • Journal of Neurology Neurosurgery & Psychiatry
  • Brain Communications

Sarah J. Tabrizi's research spans several key fields of study:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these disciplines, there is a concentration in specific subfields:

  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Neurology
  • Radiology, Nuclear Medicine and Imaging
  • Genetics

Best Publications

  • Huntington's disease: from molecular pathogenesis to clinical treatment

    Christopher A Ross;Sarah J Tabrizi

  • Huntington disease: natural history, biomarkers and prospects for therapeutics

    Christopher A Ross;Elizabeth Hoppes Aylward;Edward J Wild;Douglas R Langbehn

  • Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data.

    Sarah J Tabrizi;Douglas R Langbehn;Blair R Leavitt;Raymund A C Roos

  • Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

    Sarah J Tabrizi;Rachael I Scahill;Gail N Owen;Alexandra Durr

  • Huntington's disease: a clinical review

    Peter McColgan;Sarah J Tabrizi

  • PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-induced Cell Death

    Sonia Gandhi;Alison Wood-Kaczmar;Zhi Yao;Helene Plun-Favreau

  • A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

    Maria Björkqvist;Edward J. Wild;Jenny Thiele;Aurelio Silvestroni

  • Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis

    Sarah J Tabrizi;Rachael I Scahill;Alexandra Durr;Raymund A C Roos

  • Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data

    Sarah J Tabrizi;Ralph Reilmann;Raymond A C Roos;Alexandra Durr

  • Proteome-based plasma biomarkers for Alzheimer's disease

    A Hye;Steven Lynham;Madhav Thambisetty;M Causevic

  • Biochemical abnormalities and excitotoxicity in Huntington's disease brain

    S. J. Tabrizi;M. W. J. Cleeter;J. Xuereb;J.-W. Taanman

  • Microglial activation in presymptomatic Huntington's disease gene carriers

    Yen F. Tai;Nicola Pavese;Alexander Gerhard;Sarah J. Tabrizi

  • Targeting Huntingtin Expression in Patients with Huntington’s Disease

    Sarah J. Tabrizi;Blair R. Leavitt;G. Bernhard Landwehrmeyer;Edward J. Wild

  • Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities.

    Sarah J. Tabrizi;Michael D. Flower;Christopher A. Ross;Edward J. Wild

  • Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.

    Jon Beck;Mark Poulter;Davina Hensman;Jonathan D. Rohrer

  • Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.

    S J Tabrizi;J Workman;P E Hart;L Mangiarini

  • PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.

    Alison Wood-Kaczmar;Sonia Gandhi;Zhi Yao;Andrey S. Y. Abramov

  • Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis

    Lauren M Byrne;Filipe B. Rodrigues;Kaj Blennow;Kaj Blennow;Alexandra Durr

  • Huntington’s disease

    Marianne J U Novak;Sarah J Tabrizi

  • The Prevalence of Huntington's Disease.

    Michael D. Rawlins;Nancy S. Wexler;Alice R. Wexler;Sarah J. Tabrizi

Frequent Co-Authors

Rachael I. Scahill
Rachael I. Scahill University College London
Blair R. Leavitt
Blair R. Leavitt University of British Columbia
Alexandra Durr
Alexandra Durr Sorbonne University
Edward J. Wild
Edward J. Wild University College London
Raymund A.C. Roos
Raymund A.C. Roos Leiden University Medical Center
Julie C. Stout
Julie C. Stout Monash University
Geraint Rees
Geraint Rees University College London
Douglas R. Langbehn
Douglas R. Langbehn University of Iowa
Ralf Reilmann
Ralf Reilmann University of Tübingen
David Craufurd
David Craufurd University of Manchester

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