Michael R. Hayden

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Canada Leader Award
• 2025 - Research.com Best Scientists Award
• 2025 - Research.com Biology and Biochemistry in Canada Leader Award
• 2023 - Research.com Biology and Biochemistry in Canada Leader Award
• 2023 - Research.com Medicine in Canada Leader Award
• 2022 - Research.com Biology and Biochemistry in Canada Leader Award
• 2011 - Izaak Walton Killam Memorial Prize, Canada Council
• 2011 - Canada Gairdner Wightman Award
• 1995 - Fellow of the Royal Society of Canada Academy of Science

Overview

Best Publications

• Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

  A. Brooks-Wilson;M. Marcil;S. M. Clee;L.-H. Zhang

  2109
  Citations

• Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

  Chiara Zuccato;Andrea Ciammola;Dorotea Rigamonti;Blair R. Leavitt

  1594
  Citations

• Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

  Alexander V. Panov;Claire-Anne Gutekunst;Blair R. Leavitt;Michael R. Hayden

  1267
  Citations

• Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.

  George Papanikolaou;Mark E Samuels;Erwin H Ludwig;Marcia L E MacDonald

  1223
  Citations

• Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.

  Chiara Zuccato;Marzia Tartari;Andrea Crotti;Donato Goffredo

  1158
  Citations

• Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes.

  Jamal Nasir;Stan B Floresco;John R O'Kusky;Virginia M Diewert

  1084
  Citations

• A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

  J.Graeme Hodgson;Nadia Agopyan;Claire-Anne Gutekunst;Blair R Leavitt

  1015
  Citations

• Detection of Huntington’s disease decades before diagnosis: The Predict HD study

  Jane Paulsen;Douglas R Langbehn;Julie C Stout;Elizabeth H Aylward

  969
  Citations

• Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

  Elizabeth J. Slow;Jeremy van Raamsdonk;Daniel Rogers;Sarah H. Coleman

  942
  Citations

• A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length.

  Douglas R. Langbehn;Ryan R. Brinkman;Daniel Falush;Jane S. Paulsen

  931
  Citations

• Aspirin for the Primary Prevention of Cardiovascular Events: A Summary of the Evidence for the U.S. Preventive Services Task Force

  Michael Hayden;Michael Pignone;Christopher Phillips;Cynthia Mulrow

  885
  Citations

• A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.

  Shinji Hadano;Collette K. Hand;Hitoshi Osuga;Yoshiko Yanagisawa

  845
  Citations

• Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

  Rona K. Graham;Yu Deng;Elizabeth J. Slow;Brendan Haigh

  819
  Citations

• Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.

  Y.P. Goldberg;D.W. Nicholson;D.M. Rasper;M.A. Kalchman

  804
  Citations

• A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

  Maria Björkqvist;Edward J. Wild;Jenny Thiele;Aurelio Silvestroni

  750
  Citations

• Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease.

  Melinda M Zeron;Oskar Hansson;Nansheng Chen;Cheryl L Wellington

  739
  Citations

• Phenotypic characterization of individuals with 30-40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal elderly individuals with 36-39 repeats.

  Rubinsztein Dc;Leggo J;Coles R;Almqvist E

  732
  Citations

• Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract

  Cheryl L. Wellington;Lisa M. Ellerby;Abigail S. Hackam;Russell L. Margolis

  712
  Citations

• Huntington's Chorea

  P Beighton;M R Hayden

  645
  Citations

• Mutations in ABC1 in Tangier disease and familial high-density lipoprotein

  A Brooks-Wilson;Michel Marcil;Susanne M. Clee;Lin-Hua Zhang

  125
  Citations