World's Best Scientists 2026 revealed!
John J.P. Kastelein

John J.P. Kastelein

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Best Scientists
2025
Award Badge
Medicine
Netherlands
2026

D-Index & Metrics

Best Scientists

D-Index
182
Citations
155445
World Ranking
569
National Ranking
16

Medicine

D-Index
186
Citations
159017
World Ranking
293
National Ranking
10

Research.com Recognitions

  • 2026 - Research.com Medicine in Netherlands Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in Netherlands Leader Award
  • 2023 - Research.com Medicine in Netherlands Leader Award
  • 2022 - Research.com Medicine in Netherlands Leader Award

Overview

John J.P. Kastelein is affiliated with the University of Amsterdam in the Netherlands. Their research primarily centers on medicine, with a significant emphasis on several subfields including surgery, endocrinology, diabetes and metabolism, economics and econometrics, cardiology and cardiovascular medicine, and cancer research. The scope of their work broadly covers topics related to lipoproteins and cardiovascular health, diabetes and cardiovascular risks, cancer and lipid metabolism, pharmaceutical economics and policy, lipid metabolism and disorders, health systems with economic evaluations and quality of life, and cholesterol and lipid metabolism.

Kastelein has contributed extensively to the scientific community with numerous publications. Frequent venues for their work include Atherosclerosis, Journal of Clinical Lipidology, Journal of the American College of Cardiology, Circulation, and the New England Journal of Medicine. This reflects a strong focus on cardiovascular and lipid-related research within both clinical and biomedical contexts.

The scientist has authored or co-authored several notable papers, including:

  • "Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol" (2020, New England Journal of Medicine)
  • "Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk" (2020, JAMA)
  • "Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia" (2020, New England Journal of Medicine)
  • "Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients" (2023, New England Journal of Medicine)
  • "Evinacumab for Homozygous Familial Hypercholesterolemia" (2020, New England Journal of Medicine)

John J.P. Kastelein has collaborated frequently with a core network of coauthors, indicating ongoing professional relationships within the field of cardiovascular and lipid research. These coauthors include Marc Ditmarsch, Kausik K. Ray, Frederick J. Raal, Michael H. Davidson, and Stephen J. Nicholls.

Best Publications

  • Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

    Paul M Ridker;Brendan M. Everett;Tom Thuren;Jean G. MacFadyen

  • Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein

    Paul M. Ridker;Eleanor Danielson;Francisco A. H. Fonseca;Jacques Genest

  • Intensive lipid lowering with atorvastatin in patients with stable coronary disease.

    John C. LaRosa;Scott M Grundy;David D. Waters;Charles Shear

  • Biological, clinical and population relevance of 95 loci for blood lipids

    Tanya M. Teslovich;Kiran Musunuru;Albert V. Smith;Andrew C. Edmondson

  • Effects of Torcetrapib in Patients at High Risk for Coronary Events

    Philip J. Barter;Mark Caulfield;Mats Eriksson;Scott M Grundy

  • Discovery and refinement of loci associated with lipid levels

    Cristen J. Willer;Ellen M. Schmidt;Sebanti Sengupta;Gina M. Peloso;Gina M. Peloso;Gina M. Peloso

  • Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events

    Jennifer G. Robinson;Michel Farnier;Michel Krempf;Jean Bergeron

  • High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial.

    Terje R. Pedersen;Ole Faergeman;John J. P. Kastelein;Anders G. Olsson

  • Defining the role of common variation in the genomic and biological architecture of adult human height

    Andrew R. Wood;Tonu Esko;Jian Yang;Sailaja Vedantam

  • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

    Heribert Schunkert;Inke R. König;Sekar Kathiresan;Muredach P. Reilly

  • HDL Cholesterol, Very Low Levels of LDL Cholesterol, and Cardiovascular Events

    Philip Barter;Antonio M. Gotto;John C. LaRosa;Jaman Maroni

  • Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy A Meta-analysis

    David Preiss;Sreenivasa Rao Kondapally Seshasai;Paul Welsh;Sabina A. Murphy

  • Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia

    John J.P. Kastelein;Fatima Akdim;Erik S.G. Stroes;Aeilko H. Zwinderman

  • Genetic studies of body mass index yield new insights for obesity biology

    Adam E. Locke;Bratati Kahali;Sonja I. Berndt;Anne E. Justice

  • Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

    Paul M Ridker;Jean G MacFadyen;Tom Thuren;Brendan M Everett

  • Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial.

    Paul M Ridker;Eleanor Danielson;Francisco Ah Fonseca;Jacques Genest

  • Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial

    Stephen J. Nicholls;Stephen J. Nicholls;Rishi Puri;Todd Anderson;Christie M. Ballantyne

  • Two Phase 3 Trials of Inclisiran in Patients With Elevated LDL Cholesterol

    Kausik K. Ray;R. Scott Wright;David Kallend;Wolfgang Koenig;Wolfgang Koenig

  • Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

    David Preiss;Sreenivasa Rao Kondapally;Paul Welsh;Sabina A. Murphy

  • Intensive Lipid Lowering With Atorvastatin in Patients With Stable Coronary Disease

    J.C. LaRosa;S.M. Grundy;D.D. Waters

Frequent Co-Authors

Erik S.G. Stroes
Erik S.G. Stroes University of Amsterdam
G. Kees Hovingh
G. Kees Hovingh University of Amsterdam
S. Matthijs Boekholdt
S. Matthijs Boekholdt University of Amsterdam
Nicholas J. Wareham
Nicholas J. Wareham University of Cambridge
Kay-Tee Khaw
Kay-Tee Khaw University of Cambridge
Michael R. Hayden
Michael R. Hayden University of British Columbia
J. Wouter Jukema
J. Wouter Jukema Leiden University Medical Center
Eric J.G. Sijbrands
Eric J.G. Sijbrands Erasmus University Rotterdam
Kausik K. Ray
Kausik K. Ray Imperial College London
Wolfgang Koenig
Wolfgang Koenig German Heart Centre

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