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D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
14035
World Ranking
13668
National Ranking
51

Overview

Roshni R. Singaraja is affiliated with the Agency for Science, Technology and Research in Singapore. Their research spans multiple fields focusing primarily on medicine and biochemistry, genetics, and molecular biology.

Their scholarly work covers diverse subfields including physiology, molecular biology, surgery, cellular and molecular neuroscience, and pharmacology. This range of sub-disciplines reflects a broad approach to understanding biological and medical phenomena at multiple levels of complexity.

Major topics in their research include drug transport and resistance mechanisms, dietary effects on health, adipose tissue and metabolism, lipoproteins and cardiovascular health, angiogenesis and VEGF in cancer, diet and metabolism studies, and neuroscience and neuropharmacology research.

Some recent publications by Roshni R. Singaraja include:

  • Bile Acids: A Communication Channel in the Gut-Brain Axis, 2020, NeuroMolecular Medicine
  • Stem cell-derived polarized hepatocytes, 2020, Nature Communications
  • Lipid efflux mechanisms, relation to disease and potential therapeutic aspects, 2020, Advanced Drug Delivery Reviews
  • Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy, 2022, Autophagy
  • Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans, 2022, Journal of Clinical Investigation

Frequently publishing in venues such as bioRxiv (Cold Spring Harbor Laboratory), eLife, Journal of Lipid Research, Circulation, and NeuroMolecular Medicine, their research is positioned within respected scientific platforms.

Collaborations reflect a network of frequent co-authors who have contributed to their research efforts. The notable co-authors include David Castaño, Elisa A. Liehn, Chutima Rattanasopa, Dong-Gyu Jo, and Maria Corlianò.

Best Publications

  • A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

    J.Graeme Hodgson;Nadia Agopyan;Claire-Anne Gutekunst;Blair R Leavitt

  • A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.

    Shinji Hadano;Collette K. Hand;Hitoshi Osuga;Yoshiko Yanagisawa

  • Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract

    Cheryl L. Wellington;Lisa M. Ellerby;Abigail S. Hackam;Russell L. Margolis

  • Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.

    Diane Martindale;Abigail Hackam;Andrew Wieczorek;Lisa Ellerby;Lisa Ellerby

  • Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy.

    Johane Robitaille;Marcia L E MacDonald;Ajamete Kaykas;Laird C Sheldahl

  • Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

    Cheryl L. Wellington;Lisa M. Ellerby;Claire-Anne Gutekunst;Danny Rogers

  • Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.

    Cheryl L. Wellington;Roshni Singaraja;Lisa Ellerby;Jane Savill

  • The Influence of Huntingtin Protein Size on Nuclear Localization and Cellular Toxicity

    Abigail S. Hackam;Roshni Singaraja;Cheryl L. Wellington;Martina Metzler

  • Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

    François G. Gervais;Roshni Singaraja;Steven Xanthoudakis;Claire-Anne Gutekunst

  • Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.

    Anat Yanai;Kun Huang;Rujun Kang;Roshni R Singaraja

  • Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.

    Kun Huang;Anat Yanai;Rujun Kang;Pamela Arstikaitis

  • Increased ABCA1 activity protects against atherosclerosis

    Roshni R. Singaraja;Catherine Fievet;Graciela Castro;Erick R. James

  • ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

    Cheryl L Wellington;Elizabeth K Y Walker;Agripina Suarez;Anita Kwok

  • Efflux and atherosclerosis - the clinical and biochemical impact of variations in the abca1 gene

    Roshni R. Singaraja;Liam R. Brunham;Henk Visscher;John J.P. Kastelein

  • Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo.

    Blair R. Leavitt;Julian A. Guttman;J.Graeme Hodgson;Gil H. Kimel

  • Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

    E Hermel;E Hermel;J Gafni;S S Propp;B R Leavitt

  • HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis

    Roshni R. Singaraja;Shinji Hadano;Martina Metzler;Scott Givan

  • Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.

    Roshni R. Singaraja;Virginie Bocher;Erick R. James;Susanne M. Clee

  • Macrophage ATP-Binding Cassette Transporter A1 Overexpression Inhibits Atherosclerotic Lesion Progression in Low-Density Lipoprotein Receptor Knockout Mice

    Miranda Van Eck;Roshni R. Singaraja;Dan Ye;Reeni B. Hildebrand

  • Synaptic Imbalance, Stereotypies, and Impaired Social Interactions in Mice with Altered Neuroligin 2 Expression

    Rochelle M. Hines;Longjun Wu;Dustin J. Hines;Hendrik Steenland

Frequent Co-Authors

Michael R. Hayden
Michael R. Hayden University of British Columbia
Catherine Fievet
Catherine Fievet Institut Pasteur
Blair R. Leavitt
Blair R. Leavitt University of British Columbia
John J.P. Kastelein
John J.P. Kastelein University of Amsterdam
Bart Staels
Bart Staels University of Lille
Dale E. Bredesen
Dale E. Bredesen University of California, Los Angeles
John S. Parks
John S. Parks Wake Forest University
Donald W. Nicholson
Donald W. Nicholson MSD (United States)
Lynn A. Raymond
Lynn A. Raymond University of British Columbia
Marie-Pierre Dubé
Marie-Pierre Dubé Montreal Heart Institute

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