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Biology and Biochemistry

D-Index
65
Citations
32223
World Ranking
8931
National Ranking
3965

Overview

Lisa M. Ellerby is affiliated with the Buck Institute for Research on Aging in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine, reflecting interdisciplinary expertise in molecular and cellular processes related to aging and neurodegenerative diseases.

Their work deeply engages with subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Physiology, and Cell Biology. This broad range informs investigations into complex biological mechanisms underlying neurological conditions and age-related pathologies.

The main topics studied by Ellerby include Genetic Neurodegenerative Diseases, Mitochondrial Function and Pathology, Neuroinflammation and Neurodegeneration Mechanisms, Alzheimer's disease research and treatments, Endoplasmic Reticulum Stress and Disease, Ubiquitin and proteasome pathways, and Neurological disorders and treatments.

Frequent publication venues for their work include bioRxiv (Cold Spring Harbor Laboratory) with 15 publications, SSRN Electronic Journal with 5, as well as Amino Acids and Cell Reports with 2 publications each, along with Innovation in Aging, also appearing twice.

Significant published papers by Lisa M. Ellerby include:

  • Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates, 2020, Acta Neuropathologica
  • Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels, 2021, Autophagy
  • Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets, 2023, Molecular & Cellular Proteomics
  • Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease, 2023, Journal of Bone Metabolism
  • FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16INK4a increase, 2020, Aging Cell

Collaborations feature prominently in their career, with frequent co-authors including Birgit Schilling, Carlos Galicia Aguirre, Kizito-Tshitoko Tshilenge, Michelle E. Ehrlich, and Joanna Bons. These recurring partnerships suggest active roles in collaborative research efforts within their scientific community.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Bax directly induces release of cytochrome c from isolated mitochondria

    Juliane M. Jürgensmeier;Zhihua Xie;Quinn Deveraux;Lisa Ellerby

  • Anti-cancer activity of targeted pro-apoptotic peptides

    H. Michael Ellerby;H. Michael Ellerby;Wadih Arap;Lisa M. Ellerby;Lisa M. Ellerby;Renate Kain;Renate Kain

  • Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

    Henning R. Stennicke;Juliane M. Jürgensmeier;Hwain Shin;Quinn Deveraux

  • Encapsulation of proteins in transparent porous silicate glasses prepared by the sol-gel method

    Lisa M. Ellerby;Clinton R. Nishida;Fumito Nishida;Stacey A. Yamanaka

  • Lysosomal Protease Pathways to Apoptosis: CLEAVAGE OF Bid, NOT PRO-CASPASES, IS THE MOST LIKELY ROUTE *

    Veronika Stoka;Veronika Stoka;Boris Turk;Sharon L. Schendel;Tae Hyoung Kim

  • Coupling Endoplasmic Reticulum Stress to the Cell Death Program MECHANISM OF CASPASE ACTIVATION

    Rammohan V. Rao;Evan Hermel;Susana Castro-Obregon;Gabriel del Rio

  • Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo: A Novel Therapy for Parkinson's Disease

    Deepinder Kaur;Ferda Yantiri;Subramanian Rajagopalan;Jyothi Kumar

  • Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

    Rammohan V. Rao;Alyson Peel;Anna Logvinova;Gabriel del Rio

  • Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract

    Cheryl L. Wellington;Lisa M. Ellerby;Abigail S. Hackam;Russell L. Margolis

  • Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

    Stanislaw Krajewski;Maryla Krajewska;Lisa M. Ellerby;Kate Welsh

  • Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.

    Diane Martindale;Abigail Hackam;Andrew Wieczorek;Lisa Ellerby;Lisa Ellerby

  • A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor

    Daniel C. Lu;Daniel C. Lu;Shahrooz Rabizadeh;Shahrooz Rabizadeh;Sreeganga Chandra;Rana F. Shayya

  • Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

    Sang-Won Min;Xu Chen;Tara E Tracy;Yaqiao Li

  • Huntingtin interacting proteins are genetic modifiers of neurodegeneration.

    Linda S. Kaltenbach;Eliana Romero;Robert R. Becklin;Rakesh Chettier

  • Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

    Cheryl L. Wellington;Lisa M. Ellerby;Claire-Anne Gutekunst;Danny Rogers

  • Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.

    Cheryl L. Wellington;Roshni Singaraja;Lisa Ellerby;Jane Savill

  • Calpain Activation in Huntington's Disease

    Juliette Gafni;Lisa M. Ellerby

  • Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells.

    Mahru C. An;Ningzhe Zhang;Gary Scott;Daniel Montoro

  • Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.

    Juliette Gafni;Evan Hermel;Evan Hermel;Jessica E. Young;Cheryl L. Wellington

Frequent Co-Authors

Dale E. Bredesen
Dale E. Bredesen University of California, Los Angeles
Albert R. La Spada
Albert R. La Spada University of California, Irvine
Joan Selverstone Valentine
Joan Selverstone Valentine University of California, Los Angeles
Michael R. Hayden
Michael R. Hayden University of British Columbia
Bradford W. Gibson
Bradford W. Gibson Buck Institute for Research on Aging
Sean D. Mooney
Sean D. Mooney University of Washington
Christopher A. Ross
Christopher A. Ross Johns Hopkins University School of Medicine
Birgit Schilling
Birgit Schilling Buck Institute for Research on Aging
Guy S. Salvesen
Guy S. Salvesen Sanford Burnham Prebys Medical Discovery Institute
Blair R. Leavitt
Blair R. Leavitt University of British Columbia

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